Viral Recombinant Vaccines to the E6 and E7 Antigens of HPV-16

Most cancerous lesions of the uterine cervix are linked to persistent infections with human papillomaviruses (HPV), most notably HPV-16 or -18. Vaccine-induced immune responses to the HPV early antigens E6 and E7, which contribute to cell transformation and are thus expressed in these cervical cance...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2000-04, Vol.270 (1), p.146-161
Hauptverfasser:	He, Z., Wlazlo, A.P., Kowalczyk, D.W., Cheng, J., Xiang, Z.Q., Giles-Davis, W., Ertl, H.C.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses, Human - genetics AE6 protein AE7 protein Animals Antigens, Viral - immunology CD4 antigen CD8 antigen E6 antigen E7 antigen Female Genetic Vectors - genetics Human papillomavirus 16 Interferon-gamma - genetics Interferon-gamma - immunology Lung Neoplasms - immunology Lung Neoplasms - metabolism Lung Neoplasms - prevention & control Lung Neoplasms - secondary Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Neoplasm Transplantation Oncogene Proteins, Viral - immunology Papillomaviridae - immunology Papillomavirus E7 Proteins Papillomavirus Vaccines Repressor Proteins T-Lymphocyte Subsets - immunology T-Lymphocytes, Cytotoxic - immunology Tumor Cells, Cultured Vaccines, Synthetic - immunology Vaccinia virus - genetics Viral Vaccines - immunology
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