L-arginine during long-term ischemia: effects on cardiac function, energetic metabolism and endothelial damage

Background: We have evaluated the addition of L-arginine, a precursor of nitric oxide, to a cardioplegic solution (named CRMBM) designed for long-term heart preservation. Isolated isovolumic-perfused rat hearts ( n = 22) were arrested with the CRMBM solution either with (Arg) or without L-arginine (...

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Veröffentlicht in:	The Journal of heart and lung transplantation 2000-04, Vol.19 (4), p.367-376
Hauptverfasser:	Desrois, Martine, Sciaky, Martine, Lan, Carole, Cozzone, Patrick J, Bernard, Monique
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Arginine - pharmacology Biological and medical sciences Cardioplegic Solutions - pharmacology Clinical death. Palliative care. Organ gift and preservation Coronary Circulation - drug effects Endothelium, Vascular - drug effects Endothelium, Vascular - pathology Energy Metabolism - drug effects Hemodynamics - drug effects In Vitro Techniques Magnetic Resonance Imaging Male Medical sciences Myocardial Ischemia - diagnosis Myocardial Ischemia - prevention & control Organ Preservation - methods Rats Rats, Sprague-Dawley Reference Values Sensitivity and Specificity
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