Effects of bacterial lipopolysaccharide on central monoamines and fever in the rat: involvement of the vagus
Lipopolysaccharide (LPS) is known to produce a number of central and neuroendocrine effects but the mechanisms involved are still unclear. This study was done to investigate the possibility that LPS-induced fever and activation of central monoamines are mediated through the vagus. Adult male rats we...
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| Veröffentlicht in: | Neuroscience letters 2000-04, Vol.284 (3), p.159-162 |
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| creator | MohanKumar, Sheba M.J. MohanKumar, P.S. Quadri, S.K. |
| description | Lipopolysaccharide (LPS) is known to produce a number of central and neuroendocrine effects but the mechanisms involved are still unclear. This study was done to investigate the possibility that LPS-induced fever and activation of central monoamines are mediated through the vagus. Adult male rats were subjected to sub-diaphragmatic vagotomy (SDV), or sham operation and treated with saline or LPS in saline (10 μg/kg bw) 2 h later. Rectal temperature was monitored at half-hourly intervals for 5 h after which the animals were sacrificed and monoamine concentrations in hypothalamic nuclei were measured using HPLC-EC. SDV delayed the rise in rectal temperature induced by LPS by 1 h when compared to Sham animals. It also increased the concentrations of monoamines in the paraventricular nucleus of both Sham and SDV rats. This indicates that routes other than the vagus probably mediate LPS’ actions on the central nervous system. |
| doi_str_mv | 10.1016/S0304-3940(00)01025-9 |
| format | Article |
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This study was done to investigate the possibility that LPS-induced fever and activation of central monoamines are mediated through the vagus. Adult male rats were subjected to sub-diaphragmatic vagotomy (SDV), or sham operation and treated with saline or LPS in saline (10 μg/kg bw) 2 h later. Rectal temperature was monitored at half-hourly intervals for 5 h after which the animals were sacrificed and monoamine concentrations in hypothalamic nuclei were measured using HPLC-EC. SDV delayed the rise in rectal temperature induced by LPS by 1 h when compared to Sham animals. It also increased the concentrations of monoamines in the paraventricular nucleus of both Sham and SDV rats. This indicates that routes other than the vagus probably mediate LPS’ actions on the central nervous system.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(00)01025-9</identifier><identifier>PMID: 10773423</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biogenic Monoamines - metabolism ; Biological and medical sciences ; Body Temperature ; Chromatography, High Pressure Liquid ; Dopamine - metabolism ; Fever ; Fever - chemically induced ; Fever - metabolism ; Fever - physiopathology ; Fundamental and applied biological sciences. Psychology ; HPLC ; Hypothalamo-pituitary-adrenal ; Hypothalamus ; Lipopolysaccharide ; Lipopolysaccharides - pharmacology ; Male ; Monoamines ; Norepinephrine - metabolism ; Paraventricular Hypothalamic Nucleus - drug effects ; Paraventricular Hypothalamic Nucleus - metabolism ; Paraventricular Hypothalamic Nucleus - physiopathology ; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ ; Rats ; Rats, Sprague-Dawley ; Serotonin - metabolism ; Time Factors ; Vagotomy ; Vagus ; Vagus Nerve - drug effects ; Vagus Nerve - physiology ; Vagus Nerve - surgery ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2000-04, Vol.284 (3), p.159-162</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-7808c164fda0face1cd10e9f008078ebbe62e15c35c3b4f4202ea7077b53ff193</citedby><cites>FETCH-LOGICAL-c421t-7808c164fda0face1cd10e9f008078ebbe62e15c35c3b4f4202ea7077b53ff193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3940(00)01025-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1404486$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10773423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MohanKumar, Sheba M.J.</creatorcontrib><creatorcontrib>MohanKumar, P.S.</creatorcontrib><creatorcontrib>Quadri, S.K.</creatorcontrib><title>Effects of bacterial lipopolysaccharide on central monoamines and fever in the rat: involvement of the vagus</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Lipopolysaccharide (LPS) is known to produce a number of central and neuroendocrine effects but the mechanisms involved are still unclear. This study was done to investigate the possibility that LPS-induced fever and activation of central monoamines are mediated through the vagus. Adult male rats were subjected to sub-diaphragmatic vagotomy (SDV), or sham operation and treated with saline or LPS in saline (10 μg/kg bw) 2 h later. Rectal temperature was monitored at half-hourly intervals for 5 h after which the animals were sacrificed and monoamine concentrations in hypothalamic nuclei were measured using HPLC-EC. SDV delayed the rise in rectal temperature induced by LPS by 1 h when compared to Sham animals. It also increased the concentrations of monoamines in the paraventricular nucleus of both Sham and SDV rats. This indicates that routes other than the vagus probably mediate LPS’ actions on the central nervous system.</description><subject>Animals</subject><subject>Biogenic Monoamines - metabolism</subject><subject>Biological and medical sciences</subject><subject>Body Temperature</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dopamine - metabolism</subject><subject>Fever</subject><subject>Fever - chemically induced</subject><subject>Fever - metabolism</subject><subject>Fever - physiopathology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HPLC</subject><subject>Hypothalamo-pituitary-adrenal</subject><subject>Hypothalamus</subject><subject>Lipopolysaccharide</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Male</subject><subject>Monoamines</subject><subject>Norepinephrine - metabolism</subject><subject>Paraventricular Hypothalamic Nucleus - drug effects</subject><subject>Paraventricular Hypothalamic Nucleus - metabolism</subject><subject>Paraventricular Hypothalamic Nucleus - physiopathology</subject><subject>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Serotonin - metabolism</subject><subject>Time Factors</subject><subject>Vagotomy</subject><subject>Vagus</subject><subject>Vagus Nerve - drug effects</subject><subject>Vagus Nerve - physiology</subject><subject>Vagus Nerve - surgery</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrFTEQgIMo7WvtT1ByEGkPq5NsdrPrRaS0KhQ82J5DNjuxkWzyTPYt9N-b7Xtob4WBhOTLzGQ-Qt4w-MCAtR9_Qg2iqnsB5wAXwIA3Vf-CbFgneSV7yV-SzT_kmJzk_BsAGtaII3LMQMpa8HpD_JW1aOZMo6WDNjMmpz31bhu30T9kbcy9Tm5EGgM1GOZUbqcYop5cwEx1GKnFBRN1gc73SJOeP5X9Ev2CU-HXvOv5on_t8mvyymqf8eywnpK766vby2_VzY-v3y-_3FRGcDZXsoPOsFbYUYPVBpkZGWBvATqQHQ4DthxZY-oSg7CCA0cty5eGpraW9fUpeb_Pu03xzw7zrCaXDXqvA8ZdVpJBA6LtngWZbAV0PS9gswdNijkntGqb3KTTg2KgVh_q0Ydah62gxOpDrZ28PRTYDROOT17tBRTg3QHQ2Whvkw7G5f-cACG6tmCf9xiWsS0Ok8rGYTA4ulT0qTG6Zzr5C-Owp8c</recordid><startdate>20000428</startdate><enddate>20000428</enddate><creator>MohanKumar, Sheba M.J.</creator><creator>MohanKumar, P.S.</creator><creator>Quadri, S.K.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20000428</creationdate><title>Effects of bacterial lipopolysaccharide on central monoamines and fever in the rat: involvement of the vagus</title><author>MohanKumar, Sheba M.J. ; MohanKumar, P.S. ; Quadri, S.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-7808c164fda0face1cd10e9f008078ebbe62e15c35c3b4f4202ea7077b53ff193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Biogenic Monoamines - metabolism</topic><topic>Biological and medical sciences</topic><topic>Body Temperature</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dopamine - metabolism</topic><topic>Fever</topic><topic>Fever - chemically induced</topic><topic>Fever - metabolism</topic><topic>Fever - physiopathology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HPLC</topic><topic>Hypothalamo-pituitary-adrenal</topic><topic>Hypothalamus</topic><topic>Lipopolysaccharide</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Male</topic><topic>Monoamines</topic><topic>Norepinephrine - metabolism</topic><topic>Paraventricular Hypothalamic Nucleus - drug effects</topic><topic>Paraventricular Hypothalamic Nucleus - metabolism</topic><topic>Paraventricular Hypothalamic Nucleus - physiopathology</topic><topic>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Serotonin - metabolism</topic><topic>Time Factors</topic><topic>Vagotomy</topic><topic>Vagus</topic><topic>Vagus Nerve - drug effects</topic><topic>Vagus Nerve - physiology</topic><topic>Vagus Nerve - surgery</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MohanKumar, Sheba M.J.</creatorcontrib><creatorcontrib>MohanKumar, P.S.</creatorcontrib><creatorcontrib>Quadri, S.K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MohanKumar, Sheba M.J.</au><au>MohanKumar, P.S.</au><au>Quadri, S.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of bacterial lipopolysaccharide on central monoamines and fever in the rat: involvement of the vagus</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2000-04-28</date><risdate>2000</risdate><volume>284</volume><issue>3</issue><spage>159</spage><epage>162</epage><pages>159-162</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Lipopolysaccharide (LPS) is known to produce a number of central and neuroendocrine effects but the mechanisms involved are still unclear. This study was done to investigate the possibility that LPS-induced fever and activation of central monoamines are mediated through the vagus. Adult male rats were subjected to sub-diaphragmatic vagotomy (SDV), or sham operation and treated with saline or LPS in saline (10 μg/kg bw) 2 h later. Rectal temperature was monitored at half-hourly intervals for 5 h after which the animals were sacrificed and monoamine concentrations in hypothalamic nuclei were measured using HPLC-EC. SDV delayed the rise in rectal temperature induced by LPS by 1 h when compared to Sham animals. It also increased the concentrations of monoamines in the paraventricular nucleus of both Sham and SDV rats. This indicates that routes other than the vagus probably mediate LPS’ actions on the central nervous system.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10773423</pmid><doi>10.1016/S0304-3940(00)01025-9</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Biogenic Monoamines - metabolism Biological and medical sciences Body Temperature Chromatography, High Pressure Liquid Dopamine - metabolism Fever Fever - chemically induced Fever - metabolism Fever - physiopathology Fundamental and applied biological sciences. Psychology HPLC Hypothalamo-pituitary-adrenal Hypothalamus Lipopolysaccharide Lipopolysaccharides - pharmacology Male Monoamines Norepinephrine - metabolism Paraventricular Hypothalamic Nucleus - drug effects Paraventricular Hypothalamic Nucleus - metabolism Paraventricular Hypothalamic Nucleus - physiopathology Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Rats Rats, Sprague-Dawley Serotonin - metabolism Time Factors Vagotomy Vagus Vagus Nerve - drug effects Vagus Nerve - physiology Vagus Nerve - surgery Vertebrates: nervous system and sense organs |
| title | Effects of bacterial lipopolysaccharide on central monoamines and fever in the rat: involvement of the vagus |
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