The Subunit Structure and Catalytic Mechanism of the Bacillus subtilis DNA Repair Enzyme Spore Photoproduct Lyase

The major DNA photoproduct of dormant, UV-irradiated Bacillus subtilis spores is the thymine dimer 5-thyminyl-5,6-dihydrothymine [spore photoproduct (SP)]. During spore germination, SP is reversed to two intact thymines in situ by the DNA repair enzyme SP lyase, an S-adenosylmethionine (S-AdoMet)-de...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2001-07, Vol.98 (16), p.9038-9043
Hauptverfasser: Rebeil, Roberto, Nicholson, Wayne L.
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Sprache:eng
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