Effects of acetyl-L-carnitine on the formation of Fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat
Increasing evidence suggests that Fatty acid ethyl esters (FAEE) play a central role in ethanol induced organ damage. In the current study we measured FAEE formation in rats after short-term oral administration of ethanol, in the presence and absence of pre-treatment with acetyl-L-carnitine. Ethanol...
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| Veröffentlicht in: | Neurochemical research 2001-02, Vol.26 (2), p.167-174 |
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| creator | CALABRESE, V SCAPAGNINI, G CATALANO, C DINOTTA, F BATES, T. E CALVANI, M STELLA, A. M |
| description | Increasing evidence suggests that Fatty acid ethyl esters (FAEE) play a central role in ethanol induced organ damage. In the current study we measured FAEE formation in rats after short-term oral administration of ethanol, in the presence and absence of pre-treatment with acetyl-L-carnitine. Ethanol treatment caused a significant increase in the levels of FAEE, particularly in the brain and heart, but also in the kidney and liver. Increases in FAEE were associated with a significant increase in FAEE synthase activity, GSH transferase activity, and lipid hydroperoxide levels. Pretreatment with acetyl-L-carnitine resulted in a significant reduction of FAEE accumulation, decrease in FAEE synthase and GSH transferase activities, and lipid hydroperoxide levels. Administration of acetyl-L-carnitine greatly reduced the metabolic abnormalities due to non-oxidative ethanol metabolism, through an increment in lipid metabolism/turnover and by the modulation of the activities of enzymes associated with FAEE synthesis. These results suggest a potentially important pharmacological role for acetyl-L-carnitine in the prevention of alcohol-induced cellular damage. |
| doi_str_mv | 10.1023/A:1011003030287 |
| format | Article |
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Administration of acetyl-L-carnitine greatly reduced the metabolic abnormalities due to non-oxidative ethanol metabolism, through an increment in lipid metabolism/turnover and by the modulation of the activities of enzymes associated with FAEE synthesis. 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E</creatorcontrib><creatorcontrib>CALVANI, M</creatorcontrib><creatorcontrib>STELLA, A. M</creatorcontrib><title>Effects of acetyl-L-carnitine on the formation of Fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><description>Increasing evidence suggests that Fatty acid ethyl esters (FAEE) play a central role in ethanol induced organ damage. In the current study we measured FAEE formation in rats after short-term oral administration of ethanol, in the presence and absence of pre-treatment with acetyl-L-carnitine. Ethanol treatment caused a significant increase in the levels of FAEE, particularly in the brain and heart, but also in the kidney and liver. Increases in FAEE were associated with a significant increase in FAEE synthase activity, GSH transferase activity, and lipid hydroperoxide levels. 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These results suggest a potentially important pharmacological role for acetyl-L-carnitine in the prevention of alcohol-induced cellular damage.</description><subject>acetylcarnitine</subject><subject>Acetylcarnitine - pharmacology</subject><subject>Acyltransferases - metabolism</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Ethanol - pharmacology</subject><subject>Fatty Acids - biosynthesis</subject><subject>Glutathione Transferase - metabolism</subject><subject>Lipid Peroxides - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Time Factors</subject><subject>Tissue Distribution</subject><subject>Toxicology</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0UFrHCEUAGApLcl2k3NvRUrpbVqfOuNMbiEkbSHQS3Me3jrPrmFGN-oe9pfk79aQLYFcqqBP-N7Th4x9APEVhFTfLi9AAAih6pS9ecNW0BrVdINQb9lKqE43CgZxyt7nfC9ElRJO2CmANr3ResUer50jWzKPjqOlcpib28ZiCr74QDwGXrbEXUwLFl9Pld1gKYeK_cSpbA8zp1woZe4D3ySsK4aJ7yj53ZYSzjymPxgyR1cVz9uYSlOj5SkZQ5w5TosPPpf0fEMtUKMz9s7hnOn8uK_Z3c3176sfze2v7z-vLusbZduWRqLtJ4OdbDUpYxwpB6IFLeRgJVFnNx06M7W2k9BaEtJIN2nUvXZEfSvVmn15rrtL8WFfOxkXny3NMwaK-zwaEHoYwPwXQg9mqLrCT6_gfdynUJsYpQRj1NNYs49HtN8sNI275BdMh_Hfx1Tw-QgwW5xdwmB9fnGiU3rQ6i-CwZ29</recordid><startdate>200102</startdate><enddate>200102</enddate><creator>CALABRESE, V</creator><creator>SCAPAGNINI, G</creator><creator>CATALANO, C</creator><creator>DINOTTA, F</creator><creator>BATES, T. 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| ispartof | Neurochemical research, 2001-02, Vol.26 (2), p.167-174 |
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| subjects | acetylcarnitine Acetylcarnitine - pharmacology Acyltransferases - metabolism Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Brain - drug effects Brain - metabolism Ethanol - pharmacology Fatty Acids - biosynthesis Glutathione Transferase - metabolism Lipid Peroxides - metabolism Male Medical sciences Rats Rats, Wistar Time Factors Tissue Distribution Toxicology |
| title | Effects of acetyl-L-carnitine on the formation of Fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat |
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