A novel somatostatin analogue prevents early renal complications in the nonobese diabetic mouse

A novel somatostatin analogue prevents early renal complications in the nonobese diabetic mouse. PTR-3173 (S) is a novel somatostatin analogue that has been found to exert a prolonged inhibitory action on the growth hormone (GH)-insulin-like growth factor (IGF)-I axis, but not on insulin secretion....

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Veröffentlicht in:	Kidney international 2001-08, Vol.60 (2), p.505-512
Hauptverfasser:	Landau, Daniel, Segev, Yael, Afargan, Michel, Silbergeld, Aviva, Katchko, Leonid, Podshyvalov, Andrey, Phillip, Moshe
Format:	Artikel
Sprache:	eng
Schlagworte:	albuminuria Albuminuria - drug therapy Albuminuria - etiology Albuminuria - metabolism Animals Biological and medical sciences Blood Glucose - metabolism Blotting, Northern Creatinine - urine diabetes Diabetes Mellitus, Type 1 - complications Diabetic Nephropathies - drug therapy Diabetic Nephropathies - etiology Diabetic Nephropathies - prevention & control Female growth hormone Growth Hormone - antagonists & inhibitors Growth Hormone - blood Hypertrophy Insulin - metabolism Insulin Secretion Insulin-Like Growth Factor Binding Protein 1 - genetics Insulin-Like Growth Factor I - antagonists & inhibitors Insulin-Like Growth Factor I - metabolism insulin-like growth factor-I Kidney Glomerulus - pathology Kidneys Medical sciences Mice Mice, Inbred NOD Nephrology. Urinary tract diseases Organ Size PTR-3173 renal hypertrophy RNA, Messenger - analysis Somatostatin - analogs & derivatives Somatostatin - pharmacology Urinary system involvement in other diseases. Miscellaneous
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