Qualitative and Quantitative Decline in Spermatogenesis of the Follicle-Stimulating Hormone Receptor Knockout (FORKO) Mouse

Sertoli cells express functional receptors for FSH, one of the two pituitary hormones that regulate spermatogenesis in mammals. We recently produced genetic mutant (FORKO) mice that lack FSH receptor, in order to examine the effects on testicular function and fertility. Mutant males exhibited weight...

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Veröffentlicht in:	Biology of reproduction 2000-05, Vol.62 (5), p.1146-1159
Hauptverfasser:	Krishnamurthy, H, Danilovich, N, Morales, C R, Sairam, M R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bromodeoxyuridine Cell Division - genetics Chromatin - ultrastructure Dithiothreitol - pharmacology DNA - chemistry DNA - drug effects DNA - ultrastructure Epididymis - anatomy & histology Flow Cytometry Male Mice Mice, Knockout Organ Size - genetics Receptors, FSH - genetics Seminal Vesicles - anatomy & histology Seminiferous Tubules - anatomy & histology Seminiferous Tubules - cytology Sertoli Cells - pathology Sertoli Cells - physiology Spermatids Spermatogenesis - genetics Spermatozoa - cytology Spermatozoa - drug effects Spermatozoa - physiology Testis - anatomy & histology Testis - cytology Testis - physiology
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