Pathogenesis of Paget's Disease: Epidermal Heregulin-α, Motility Factor, and the HER Receptor Family

Background and Methods: In Paget's disease of the breast, the epidermis of the nipple is infiltrated by large neoplastic cells of glandular origin. It has been hypothesized that the spread of Paget cells through the nipple epidermis is induced by a motility factor that acts via the HER2/NEU rec...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2000-04, Vol.92 (8), p.622-628
Hauptverfasser:	Schelfhout, Vera R. J., Coene, Elisabeth D., Delaey, Bernard, Thys, Sofie, Page, David L., De Potter, Christian R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Sequence Biological and medical sciences Breast cancer Breast Neoplasms - etiology Cell Movement Cells, Cultured Chemotaxis Culture Media, Conditioned Epidermis - metabolism ErbB Receptors - metabolism Gynecology. Andrology. Obstetrics HER2 gene heregulin Humans Immunohistochemistry Keratinocytes Mammary gland diseases Medical sciences Molecular Sequence Data neu gene Neuregulin-1 - metabolism Non tumoral diseases Paget's Disease, Mammary - etiology Proteins Receptor, ErbB-2 Receptor, ErbB-3 - metabolism Receptor, ErbB-4
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