Humanization and characterization of the anti‐HLA‐DR antibody 1D10

1D10 is a previously described antibody that binds to cells from a majority of B‐cell malignancies. The current studies were designed to further evaluate the antigen specificity of 1D10 and its potential as an immunotherapeutic agent. Studies with transfectants and immunoprecipitation demonstrated t...

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Veröffentlicht in:	International journal of cancer 2001-08, Vol.93 (4), p.556-565
Hauptverfasser:	Kostelny, Sheri A., Link, Brian K., Tso, J. Yun, Vasquez, Max, Jorgensen, Brett H., Wang, Hong, Hall, William C., Weiner, George J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - genetics Antibodies, Monoclonal - immunology Antibody Affinity Antibody Specificity Antibody-Dependent Cell Cytotoxicity Antineoplastic agents Apoptosis - immunology Biological and medical sciences Cloning, Molecular Epitopes - immunology histocompatibility antigen HLA HLA-DR Antigens - immunology HLA‐DR Humans Immunoglobulin G - biosynthesis Immunoglobulin G - genetics Immunoglobulin G - immunology Immunotherapy Leukemia, T-Cell - immunology Leukemia, T-Cell - pathology lymphoma Lymphoma, B-Cell - immunology Lymphoma, B-Cell - pathology Medical sciences MHC class II Mice Molecular Sequence Data monoclonal antibody Pharmacology. Drug treatments Sequence Homology, Amino Acid Tumor Cells, Cultured
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