The Drosophila gene twister, an orthologue of the yeast helicase SKI2, is differentially expressed during development
We have identified and characterized a Drosophila orthologue of SKI2, which, in Saccharomyces cerevisiae, is one of the key components in the cytoplasmic 3′–5′ decay of mRNA. The Drosophila orthologue ( twister, tst), is expressed as two transcripts which differ in the lengths of their 3′-UTRs, with...
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| Veröffentlicht in: | Mechanisms of development 2001-08, Vol.106 (1), p.137-141 |
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| creator | Seago, Julian E. Chernukhin, Igor V. Newbury, Sarah F. |
| description | We have identified and characterized a
Drosophila orthologue of
SKI2, which, in
Saccharomyces cerevisiae, is one of the key components in the cytoplasmic 3′–5′ decay of mRNA. The
Drosophila orthologue (
twister,
tst), is expressed as two transcripts which differ in the lengths of their 3′-UTRs, with the smaller transcript being particularly abundant in 0–2 h embryos and the larger transcript reaching its highest levels in 6–8 h embryos. TST protein is expressed in two forms which are differentially expressed in adult tissues and throughout development. Differential expression of TST may modulate activity of the mRNA turnover pathway and could have a major impact on the expression of target RNAs. |
| doi_str_mv | 10.1016/S0925-4773(01)00429-4 |
| format | Article |
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Drosophila orthologue of
SKI2, which, in
Saccharomyces cerevisiae, is one of the key components in the cytoplasmic 3′–5′ decay of mRNA. The
Drosophila orthologue (
twister,
tst), is expressed as two transcripts which differ in the lengths of their 3′-UTRs, with the smaller transcript being particularly abundant in 0–2 h embryos and the larger transcript reaching its highest levels in 6–8 h embryos. TST protein is expressed in two forms which are differentially expressed in adult tissues and throughout development. Differential expression of TST may modulate activity of the mRNA turnover pathway and could have a major impact on the expression of target RNAs.</description><identifier>ISSN: 0925-4773</identifier><identifier>EISSN: 1872-6356</identifier><identifier>DOI: 10.1016/S0925-4773(01)00429-4</identifier><identifier>PMID: 11472843</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; DNA Helicases ; Drosophila - embryology ; Drosophila - genetics ; Drosophila - growth & development ; Drosophila - metabolism ; Drosophila development ; Drosophila Proteins ; Embryo, Nonmammalian - metabolism ; Expressed Sequence Tags ; Female ; Fungal Proteins - genetics ; Gene Expression Regulation, Developmental ; Gene regulation ; Genes, Insect ; Insect Proteins - biosynthesis ; Insect Proteins - chemistry ; Insect Proteins - genetics ; Male ; Messenger RNA degradation ; Ovary - metabolism ; Ribonucleases ; RNA stability ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Saccharomyces cerevisiae Proteins ; SKI2 ; Testis - metabolism</subject><ispartof>Mechanisms of development, 2001-08, Vol.106 (1), p.137-141</ispartof><rights>2001 Elsevier Science Ireland Ltd</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-dba854e75989a23dba195bcb111952fc99c36d565f32036356faeac58b5168d53</citedby><cites>FETCH-LOGICAL-c408t-dba854e75989a23dba195bcb111952fc99c36d565f32036356faeac58b5168d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0925477301004294$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11472843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seago, Julian E.</creatorcontrib><creatorcontrib>Chernukhin, Igor V.</creatorcontrib><creatorcontrib>Newbury, Sarah F.</creatorcontrib><title>The Drosophila gene twister, an orthologue of the yeast helicase SKI2, is differentially expressed during development</title><title>Mechanisms of development</title><addtitle>Mech Dev</addtitle><description>We have identified and characterized a
Drosophila orthologue of
SKI2, which, in
Saccharomyces cerevisiae, is one of the key components in the cytoplasmic 3′–5′ decay of mRNA. The
Drosophila orthologue (
twister,
tst), is expressed as two transcripts which differ in the lengths of their 3′-UTRs, with the smaller transcript being particularly abundant in 0–2 h embryos and the larger transcript reaching its highest levels in 6–8 h embryos. TST protein is expressed in two forms which are differentially expressed in adult tissues and throughout development. Differential expression of TST may modulate activity of the mRNA turnover pathway and could have a major impact on the expression of target RNAs.</description><subject>Animals</subject><subject>DNA Helicases</subject><subject>Drosophila - embryology</subject><subject>Drosophila - genetics</subject><subject>Drosophila - growth & development</subject><subject>Drosophila - metabolism</subject><subject>Drosophila development</subject><subject>Drosophila Proteins</subject><subject>Embryo, Nonmammalian - metabolism</subject><subject>Expressed Sequence Tags</subject><subject>Female</subject><subject>Fungal Proteins - genetics</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Gene regulation</subject><subject>Genes, Insect</subject><subject>Insect Proteins - biosynthesis</subject><subject>Insect Proteins - chemistry</subject><subject>Insect Proteins - genetics</subject><subject>Male</subject><subject>Messenger RNA degradation</subject><subject>Ovary - metabolism</subject><subject>Ribonucleases</subject><subject>RNA stability</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Saccharomyces cerevisiae Proteins</subject><subject>SKI2</subject><subject>Testis - metabolism</subject><issn>0925-4773</issn><issn>1872-6356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtuFDEQRS0EIkPgE0BeIZDS4HLb_VghFF5RIrFIWFtuu3rGyNNubHfI_D2ezCgssyqVdKqu7iHkNbAPwKD5eM16LivRtvU7Bu8ZE7yvxBOygq7lVVPL5ilZPSAn5EVKvxljAA08JycAouWdqFdkudkg_RJDCvPGeU3XOCHNf13KGM-onmiIeRN8WC9Iw0hzoXeoU6Yb9M7ohPT68oKfUZeodeOIEafstPc7indzxJTQUrtEN62pxVv0Yd4W4iV5Nmqf8NVxnpJf377enP-orn5-vzj_fFUZwbpc2UF3UmAr-67XvC4r9HIwA0CZfDR9b-rGykaONWf1vvSoURvZDRKazsr6lLw9_J1j-LNgymrrkkHv9YRhSaoFJtqeNwWUB9AUFSniqObotjruFDC1963ufau9TMVA3ftWoty9OQYswxbt_6uj4AJ8OgBYat46jCoZh5NB6yKarGxwj0T8A7VEkNc</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>Seago, Julian E.</creator><creator>Chernukhin, Igor V.</creator><creator>Newbury, Sarah F.</creator><general>Elsevier Ireland Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010801</creationdate><title>The Drosophila gene twister, an orthologue of the yeast helicase SKI2, is differentially expressed during development</title><author>Seago, Julian E. ; Chernukhin, Igor V. ; Newbury, Sarah F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-dba854e75989a23dba195bcb111952fc99c36d565f32036356faeac58b5168d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>DNA Helicases</topic><topic>Drosophila - embryology</topic><topic>Drosophila - genetics</topic><topic>Drosophila - growth & development</topic><topic>Drosophila - metabolism</topic><topic>Drosophila development</topic><topic>Drosophila Proteins</topic><topic>Embryo, Nonmammalian - metabolism</topic><topic>Expressed Sequence Tags</topic><topic>Female</topic><topic>Fungal Proteins - genetics</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Gene regulation</topic><topic>Genes, Insect</topic><topic>Insect Proteins - biosynthesis</topic><topic>Insect Proteins - chemistry</topic><topic>Insect Proteins - genetics</topic><topic>Male</topic><topic>Messenger RNA degradation</topic><topic>Ovary - metabolism</topic><topic>Ribonucleases</topic><topic>RNA stability</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Saccharomyces cerevisiae Proteins</topic><topic>SKI2</topic><topic>Testis - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Seago, Julian E.</creatorcontrib><creatorcontrib>Chernukhin, Igor V.</creatorcontrib><creatorcontrib>Newbury, Sarah F.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seago, Julian E.</au><au>Chernukhin, Igor V.</au><au>Newbury, Sarah F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Drosophila gene twister, an orthologue of the yeast helicase SKI2, is differentially expressed during development</atitle><jtitle>Mechanisms of development</jtitle><addtitle>Mech Dev</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>106</volume><issue>1</issue><spage>137</spage><epage>141</epage><pages>137-141</pages><issn>0925-4773</issn><eissn>1872-6356</eissn><abstract>We have identified and characterized a
Drosophila orthologue of
SKI2, which, in
Saccharomyces cerevisiae, is one of the key components in the cytoplasmic 3′–5′ decay of mRNA. The
Drosophila orthologue (
twister,
tst), is expressed as two transcripts which differ in the lengths of their 3′-UTRs, with the smaller transcript being particularly abundant in 0–2 h embryos and the larger transcript reaching its highest levels in 6–8 h embryos. TST protein is expressed in two forms which are differentially expressed in adult tissues and throughout development. Differential expression of TST may modulate activity of the mRNA turnover pathway and could have a major impact on the expression of target RNAs.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>11472843</pmid><doi>10.1016/S0925-4773(01)00429-4</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals DNA Helicases Drosophila - embryology Drosophila - genetics Drosophila - growth & development Drosophila - metabolism Drosophila development Drosophila Proteins Embryo, Nonmammalian - metabolism Expressed Sequence Tags Female Fungal Proteins - genetics Gene Expression Regulation, Developmental Gene regulation Genes, Insect Insect Proteins - biosynthesis Insect Proteins - chemistry Insect Proteins - genetics Male Messenger RNA degradation Ovary - metabolism Ribonucleases RNA stability RNA, Messenger - genetics RNA, Messenger - metabolism Saccharomyces cerevisiae Proteins SKI2 Testis - metabolism |
| title | The Drosophila gene twister, an orthologue of the yeast helicase SKI2, is differentially expressed during development |
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