Potential Tuberculostatic Agents: Micelle-Forming Copolymer Poly(ethylene glycol)-Poly(aspartic acid) Prodrug with Isoniazid

With the objective of obtaining slow‐acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle‐forming copolymer of poly(ethylene glycol)‐ poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2001-06, Vol.334 (6), p.189-193
Hauptverfasser:	Silva, M., Lara, A. S., Leite, C. Q. F., Ferreira, E. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents - chemical synthesis Antitubercular Agents - pharmacology Biological and medical sciences co-polymer poly(ethylene glycol)-poly(aspartic acid) Excipients isoniazid Isoniazid - chemistry Isoniazid - pharmacology Medical sciences micelle-forming polymer Micelles Microbial Sensitivity Tests Mycobacterium tuberculosis - drug effects Peptides Pharmacology. Drug treatments Polyethylene Glycols potential tuberculostatic agent prodrug Prodrugs - chemical synthesis Prodrugs - pharmacology
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