Potential Tuberculostatic Agents: Micelle-Forming Copolymer Poly(ethylene glycol)-Poly(aspartic acid) Prodrug with Isoniazid
With the objective of obtaining slow‐acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle‐forming copolymer of poly(ethylene glycol)‐ poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be...
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| Veröffentlicht in: | Archiv der Pharmazie (Weinheim) 2001-06, Vol.334 (6), p.189-193 |
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| container_title | Archiv der Pharmazie (Weinheim) |
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| creator | Silva, M. Lara, A. S. Leite, C. Q. F. Ferreira, E. I. |
| description | With the objective of obtaining slow‐acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle‐forming copolymer of poly(ethylene glycol)‐ poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug. |
| doi_str_mv | 10.1002/1521-4184(200106)334:6<189::AID-ARDP189>3.0.CO;2-6 |
| format | Article |
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S.</creatorcontrib><creatorcontrib>Leite, C. Q. F.</creatorcontrib><creatorcontrib>Ferreira, E. I.</creatorcontrib><title>Potential Tuberculostatic Agents: Micelle-Forming Copolymer Poly(ethylene glycol)-Poly(aspartic acid) Prodrug with Isoniazid</title><title>Archiv der Pharmazie (Weinheim)</title><addtitle>Arch. Pharm. Pharm. Med. Chem</addtitle><description>With the objective of obtaining slow‐acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle‐forming copolymer of poly(ethylene glycol)‐ poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug.</description><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antitubercular Agents - chemical synthesis</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>co-polymer poly(ethylene glycol)-poly(aspartic acid)</subject><subject>Excipients</subject><subject>isoniazid</subject><subject>Isoniazid - chemistry</subject><subject>Isoniazid - pharmacology</subject><subject>Medical sciences</subject><subject>micelle-forming polymer</subject><subject>Micelles</subject><subject>Microbial Sensitivity Tests</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Peptides</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyethylene Glycols</subject><subject>potential tuberculostatic agent</subject><subject>prodrug</subject><subject>Prodrugs - chemical synthesis</subject><subject>Prodrugs - pharmacology</subject><issn>0365-6233</issn><issn>1521-4184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkV1v0zAUhiMEYt3gL6BcILRepPjbSUFIVcdKpUGrMhh3R67jdB5u3NmJRhE_npSWwQU3XFm2Xz_n-DxJMsRogBEiLzEnOGM4Z6cEIYxEn1I2FK9xXgyHo-lZNlqczbvNGzpAg_HsFcnEg6R3_-hh0kNU8EwQSo-S4xhvEEIUEf44OcKYSV6gvJf8mPvG1I1VLr1slybo1vnYqMbqdLTqLuIwfW-1cc5k5z6sbb1Kx37j3XZtQjrv1lPTXG-dqU26clvtXT_7dariRoUdRWlb9tN58GVoV-mdba7TafS1Vd9t-SR5VCkXzdPDepJ8On97OX6XXcwm0_HoItMc0SLTGklZEFlUhnGWo0IYk-dUE12IUpYYa0wl0nIpCsU0Fjle8qooCSVMsopyepK82HM3wd-2JjawtnH3KVUb30aQGDEpGOqCi31QBx9jMBVsgl2rsAWMYOcEduOF3Xhh7wQ6JyCg0wDQOYGDE6CAYDwDAqKDPjtUb5drU_5BHiR0geeHgIpauSqoWtv4V2nGeFF0sc_72J11Zvs_nf27sd9HHTjbg21szLd7sApfQUgqOVx9mMDHL4srPpE5LOhPV5rB6Q</recordid><startdate>200106</startdate><enddate>200106</enddate><creator>Silva, M.</creator><creator>Lara, A. S.</creator><creator>Leite, C. Q. F.</creator><creator>Ferreira, E. I.</creator><general>WILEY-VCH Verlag GmbH</general><general>WILEY‐VCH Verlag GmbH</general><general>Wiley-VCH</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200106</creationdate><title>Potential Tuberculostatic Agents: Micelle-Forming Copolymer Poly(ethylene glycol)-Poly(aspartic acid) Prodrug with Isoniazid</title><author>Silva, M. ; Lara, A. S. ; Leite, C. Q. F. ; Ferreira, E. I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5039-cc0779279fe4548096ee883c2c96d7d11c1370c7b69a4c1681b5f9d232474f353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antitubercular Agents - chemical synthesis</topic><topic>Antitubercular Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>co-polymer poly(ethylene glycol)-poly(aspartic acid)</topic><topic>Excipients</topic><topic>isoniazid</topic><topic>Isoniazid - chemistry</topic><topic>Isoniazid - pharmacology</topic><topic>Medical sciences</topic><topic>micelle-forming polymer</topic><topic>Micelles</topic><topic>Microbial Sensitivity Tests</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>Peptides</topic><topic>Pharmacology. Drug treatments</topic><topic>Polyethylene Glycols</topic><topic>potential tuberculostatic agent</topic><topic>prodrug</topic><topic>Prodrugs - chemical synthesis</topic><topic>Prodrugs - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva, M.</creatorcontrib><creatorcontrib>Lara, A. S.</creatorcontrib><creatorcontrib>Leite, C. Q. F.</creatorcontrib><creatorcontrib>Ferreira, E. I.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archiv der Pharmazie (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva, M.</au><au>Lara, A. S.</au><au>Leite, C. Q. F.</au><au>Ferreira, E. I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential Tuberculostatic Agents: Micelle-Forming Copolymer Poly(ethylene glycol)-Poly(aspartic acid) Prodrug with Isoniazid</atitle><jtitle>Archiv der Pharmazie (Weinheim)</jtitle><addtitle>Arch. Pharm. Pharm. Med. Chem</addtitle><date>2001-06</date><risdate>2001</risdate><volume>334</volume><issue>6</issue><spage>189</spage><epage>193</epage><pages>189-193</pages><issn>0365-6233</issn><eissn>1521-4184</eissn><coden>ARPMAS</coden><abstract>With the objective of obtaining slow‐acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle‐forming copolymer of poly(ethylene glycol)‐ poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag GmbH</pub><pmid>11475908</pmid><doi>10.1002/1521-4184(200106)334:6<189::AID-ARDP189>3.0.CO;2-6</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archiv der Pharmazie (Weinheim), 2001-06, Vol.334 (6), p.189-193 |
| issn | 0365-6233 1521-4184 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents - chemical synthesis Antitubercular Agents - pharmacology Biological and medical sciences co-polymer poly(ethylene glycol)-poly(aspartic acid) Excipients isoniazid Isoniazid - chemistry Isoniazid - pharmacology Medical sciences micelle-forming polymer Micelles Microbial Sensitivity Tests Mycobacterium tuberculosis - drug effects Peptides Pharmacology. Drug treatments Polyethylene Glycols potential tuberculostatic agent prodrug Prodrugs - chemical synthesis Prodrugs - pharmacology |
| title | Potential Tuberculostatic Agents: Micelle-Forming Copolymer Poly(ethylene glycol)-Poly(aspartic acid) Prodrug with Isoniazid |
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