A morpholino phenocopy of the colourless mutant

We have utilized the modified antisense RNA morpholino technology to effectively phenocopy zebrafish colourless/sox10 (cls) mutations. The cls locus was identified in mutagenesis screens (Kelsh et al., 1996; Malicki et al., 1996). Homozygous mutants are characterized by extensive defects in nonectom...

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Veröffentlicht in:	Genesis (New York, N.Y. : 2000) N.Y. : 2000), 2001-07, Vol.30 (3), p.188-189
Hauptverfasser:	Dutton, K., Dutton, J. R., Pauliny, A., Kelsh, R. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals colorless gene Danio rerio DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Freshwater High Mobility Group Proteins - genetics High Mobility Group Proteins - metabolism Morpholino phosphorodiamidate oligonucleotides Mutation - genetics neural crest neurocristopathy Oligonucleotides, Antisense - genetics Phenotype pigmentation Pigmentation - genetics sox10 sox10 gene SOXE Transcription Factors Transcription Factors Waardenburg-Shah syndrome Zebrafish - embryology Zebrafish - genetics
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Zusammenfassung:	We have utilized the modified antisense RNA morpholino technology to effectively phenocopy zebrafish colourless/sox10 (cls) mutations. The cls locus was identified in mutagenesis screens (Kelsh et al., 1996; Malicki et al., 1996). Homozygous mutants are characterized by extensive defects in nonectomesenchymal fates (neurons, glia, and pigment cells) derived from the neural crest (Kelsh and Eisen 2000; Kelsh et al., 2000a, 2000b). Additionally, cls mutants have small otic vesicles (Whitfield et al., 1996).
ISSN:	1526-954X 1526-968X
DOI:	10.1002/gene.1062