Transduction of murine colon carcinoma cells with interleukin-15 gene induces antitumor effects in immunocompetent and immunocompromised hosts

We examined the antitumor effects caused by murine colon carcinoma cells (Colon 26) transduced with interleukin-15 (IL-15) gene. Although the in vitro proliferation rate of IL-15-secreting Colon 26 (Colon 26/IL-15) cells was not different from that of wild-type (wt) cells, small subcutaneous tumors...

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Veröffentlicht in:	Cancer gene therapy 2000-02, Vol.7 (2), p.255-261
Hauptverfasser:	Tasaki, K, Yoshida, Y, Miyauchi, M, Maeda, T, Takenaga, K, Kouzu, T, Asano, T, Ochiai, T, Sakiyamna, S, Tagawa, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antitumor activity Cell proliferation Clone Cells Colon Colonic Neoplasms - genetics Colonic Neoplasms - immunology Colonic Neoplasms - mortality Colonic Neoplasms - therapy Colorectal cancer Cytokines Female Genetic Vectors - secretion IL-15 gene Immunocompetence Immunocompetence - genetics Immunocompromised Host - genetics Immunocompromised hosts Immunodeficiency Immunohistochemistry Inoculation Interleukin 15 Interleukin-15 - genetics Interleukin-15 - secretion Interleukin-15 - therapeutic use Metastases Mice Mice, Inbred BALB C Mice, Nude Mice, SCID Natural killer cells Retroviridae - genetics Survival Analysis Transformation, Genetic - immunology Tumor cells Tumor Cells, Cultured - chemistry Tumor Cells, Cultured - immunology Tumor Cells, Cultured - secretion Tumors
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