Transduction of murine colon carcinoma cells with interleukin-15 gene induces antitumor effects in immunocompetent and immunocompromised hosts
We examined the antitumor effects caused by murine colon carcinoma cells (Colon 26) transduced with interleukin-15 (IL-15) gene. Although the in vitro proliferation rate of IL-15-secreting Colon 26 (Colon 26/IL-15) cells was not different from that of wild-type (wt) cells, small subcutaneous tumors...
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| Veröffentlicht in: | Cancer gene therapy 2000-02, Vol.7 (2), p.255-261 |
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| creator | Tasaki, K Yoshida, Y Miyauchi, M Maeda, T Takenaga, K Kouzu, T Asano, T Ochiai, T Sakiyamna, S Tagawa, M |
| description | We examined the antitumor effects caused by murine colon carcinoma cells (Colon 26) transduced with interleukin-15 (IL-15) gene. Although the in vitro proliferation rate of IL-15-secreting Colon 26 (Colon 26/IL-15) cells was not different from that of wild-type (wt) cells, small subcutaneous tumors of Colon 26/IL-15 cells that developed in syngeneic immunocompetent mice regressed spontaneously in contrast to tumors of wt cells. The mice that had eliminated tumors of Colon 26/IL-15 cells rejected wt cells when subsequently challenged. The survival of the mice that had been inoculated intraperitoneally with Colon 26/IL-15 cells was significantly prolonged compared with that of the mice injected with wt cells. However, in an experimental lung metastasis model, the survival of the mice inoculated with Colon 26/IL-15 cells remained the same as that of the mice inoculated with wt cells. The inoculation of Colon 26/IL-15 cells into immunocompromised nude or severe combined immunodeficient mice produced tumors, but the survival of the immunocompromised mice was significantly longer than that of the mice inoculated with wt cells. The nude mice inoculated with Colon 26/IL-15 cells also survived longer than the severe combined immunodeficient mice with Colon 26/IL-15 cells. Depletion of natural killer cells in nude mice with anti-asialo GM1 antibody did not influence the survival of the mice injected with Colon 26/IL-15 cells. Immunohistological examination revealed that CD31+ cells migrated into tumors of Colon 26/IL-15 cells that developed in immunocompetent and immunocompromised mice. Taken together, our results indicate that an inoculation of IL-15-producing tumor cells can produce antitumor effects that are mediated by a variety of immunocompetent cells. |
| doi_str_mv | 10.1038/sj.cgt.7700112 |
| format | Article |
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Although the in vitro proliferation rate of IL-15-secreting Colon 26 (Colon 26/IL-15) cells was not different from that of wild-type (wt) cells, small subcutaneous tumors of Colon 26/IL-15 cells that developed in syngeneic immunocompetent mice regressed spontaneously in contrast to tumors of wt cells. The mice that had eliminated tumors of Colon 26/IL-15 cells rejected wt cells when subsequently challenged. The survival of the mice that had been inoculated intraperitoneally with Colon 26/IL-15 cells was significantly prolonged compared with that of the mice injected with wt cells. However, in an experimental lung metastasis model, the survival of the mice inoculated with Colon 26/IL-15 cells remained the same as that of the mice inoculated with wt cells. The inoculation of Colon 26/IL-15 cells into immunocompromised nude or severe combined immunodeficient mice produced tumors, but the survival of the immunocompromised mice was significantly longer than that of the mice inoculated with wt cells. The nude mice inoculated with Colon 26/IL-15 cells also survived longer than the severe combined immunodeficient mice with Colon 26/IL-15 cells. Depletion of natural killer cells in nude mice with anti-asialo GM1 antibody did not influence the survival of the mice injected with Colon 26/IL-15 cells. Immunohistological examination revealed that CD31+ cells migrated into tumors of Colon 26/IL-15 cells that developed in immunocompetent and immunocompromised mice. Taken together, our results indicate that an inoculation of IL-15-producing tumor cells can produce antitumor effects that are mediated by a variety of immunocompetent cells.</description><identifier>ISSN: 0929-1903</identifier><identifier>EISSN: 1476-5500</identifier><identifier>DOI: 10.1038/sj.cgt.7700112</identifier><identifier>PMID: 10770634</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Animals ; Antitumor activity ; Cell proliferation ; Clone Cells ; Colon ; Colonic Neoplasms - genetics ; Colonic Neoplasms - immunology ; Colonic Neoplasms - mortality ; Colonic Neoplasms - therapy ; Colorectal cancer ; Cytokines ; Female ; Genetic Vectors - secretion ; IL-15 gene ; Immunocompetence ; Immunocompetence - genetics ; Immunocompromised Host - genetics ; Immunocompromised hosts ; Immunodeficiency ; Immunohistochemistry ; Inoculation ; Interleukin 15 ; Interleukin-15 - genetics ; Interleukin-15 - secretion ; Interleukin-15 - therapeutic use ; Metastases ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Mice, SCID ; Natural killer cells ; Retroviridae - genetics ; Survival Analysis ; Transformation, Genetic - immunology ; Tumor cells ; Tumor Cells, Cultured - chemistry ; Tumor Cells, Cultured - immunology ; Tumor Cells, Cultured - secretion ; Tumors</subject><ispartof>Cancer gene therapy, 2000-02, Vol.7 (2), p.255-261</ispartof><rights>Copyright Nature Publishing Group Feb 2000</rights><rights>Nature America, Inc. 2000.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-19b75c55bd45c1337275dcee0ed0edf6698d76ef8dc78f55f576ad90c7e957f73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10770634$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tasaki, K</creatorcontrib><creatorcontrib>Yoshida, Y</creatorcontrib><creatorcontrib>Miyauchi, M</creatorcontrib><creatorcontrib>Maeda, T</creatorcontrib><creatorcontrib>Takenaga, K</creatorcontrib><creatorcontrib>Kouzu, T</creatorcontrib><creatorcontrib>Asano, T</creatorcontrib><creatorcontrib>Ochiai, T</creatorcontrib><creatorcontrib>Sakiyamna, S</creatorcontrib><creatorcontrib>Tagawa, M</creatorcontrib><title>Transduction of murine colon carcinoma cells with interleukin-15 gene induces antitumor effects in immunocompetent and immunocompromised hosts</title><title>Cancer gene therapy</title><addtitle>Cancer Gene Ther</addtitle><description>We examined the antitumor effects caused by murine colon carcinoma cells (Colon 26) transduced with interleukin-15 (IL-15) gene. Although the in vitro proliferation rate of IL-15-secreting Colon 26 (Colon 26/IL-15) cells was not different from that of wild-type (wt) cells, small subcutaneous tumors of Colon 26/IL-15 cells that developed in syngeneic immunocompetent mice regressed spontaneously in contrast to tumors of wt cells. The mice that had eliminated tumors of Colon 26/IL-15 cells rejected wt cells when subsequently challenged. The survival of the mice that had been inoculated intraperitoneally with Colon 26/IL-15 cells was significantly prolonged compared with that of the mice injected with wt cells. However, in an experimental lung metastasis model, the survival of the mice inoculated with Colon 26/IL-15 cells remained the same as that of the mice inoculated with wt cells. The inoculation of Colon 26/IL-15 cells into immunocompromised nude or severe combined immunodeficient mice produced tumors, but the survival of the immunocompromised mice was significantly longer than that of the mice inoculated with wt cells. The nude mice inoculated with Colon 26/IL-15 cells also survived longer than the severe combined immunodeficient mice with Colon 26/IL-15 cells. Depletion of natural killer cells in nude mice with anti-asialo GM1 antibody did not influence the survival of the mice injected with Colon 26/IL-15 cells. Immunohistological examination revealed that CD31+ cells migrated into tumors of Colon 26/IL-15 cells that developed in immunocompetent and immunocompromised mice. Taken together, our results indicate that an inoculation of IL-15-producing tumor cells can produce antitumor effects that are mediated by a variety of immunocompetent cells.</description><subject>Animals</subject><subject>Antitumor activity</subject><subject>Cell proliferation</subject><subject>Clone Cells</subject><subject>Colon</subject><subject>Colonic Neoplasms - genetics</subject><subject>Colonic Neoplasms - immunology</subject><subject>Colonic Neoplasms - mortality</subject><subject>Colonic Neoplasms - therapy</subject><subject>Colorectal cancer</subject><subject>Cytokines</subject><subject>Female</subject><subject>Genetic Vectors - secretion</subject><subject>IL-15 gene</subject><subject>Immunocompetence</subject><subject>Immunocompetence - genetics</subject><subject>Immunocompromised Host - genetics</subject><subject>Immunocompromised hosts</subject><subject>Immunodeficiency</subject><subject>Immunohistochemistry</subject><subject>Inoculation</subject><subject>Interleukin 15</subject><subject>Interleukin-15 - 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Academic</collection><jtitle>Cancer gene therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tasaki, K</au><au>Yoshida, Y</au><au>Miyauchi, M</au><au>Maeda, T</au><au>Takenaga, K</au><au>Kouzu, T</au><au>Asano, T</au><au>Ochiai, T</au><au>Sakiyamna, S</au><au>Tagawa, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transduction of murine colon carcinoma cells with interleukin-15 gene induces antitumor effects in immunocompetent and immunocompromised hosts</atitle><jtitle>Cancer gene therapy</jtitle><addtitle>Cancer Gene Ther</addtitle><date>2000-02-01</date><risdate>2000</risdate><volume>7</volume><issue>2</issue><spage>255</spage><epage>261</epage><pages>255-261</pages><issn>0929-1903</issn><eissn>1476-5500</eissn><abstract>We examined the antitumor effects caused by murine colon carcinoma cells (Colon 26) transduced with interleukin-15 (IL-15) gene. Although the in vitro proliferation rate of IL-15-secreting Colon 26 (Colon 26/IL-15) cells was not different from that of wild-type (wt) cells, small subcutaneous tumors of Colon 26/IL-15 cells that developed in syngeneic immunocompetent mice regressed spontaneously in contrast to tumors of wt cells. The mice that had eliminated tumors of Colon 26/IL-15 cells rejected wt cells when subsequently challenged. The survival of the mice that had been inoculated intraperitoneally with Colon 26/IL-15 cells was significantly prolonged compared with that of the mice injected with wt cells. However, in an experimental lung metastasis model, the survival of the mice inoculated with Colon 26/IL-15 cells remained the same as that of the mice inoculated with wt cells. The inoculation of Colon 26/IL-15 cells into immunocompromised nude or severe combined immunodeficient mice produced tumors, but the survival of the immunocompromised mice was significantly longer than that of the mice inoculated with wt cells. The nude mice inoculated with Colon 26/IL-15 cells also survived longer than the severe combined immunodeficient mice with Colon 26/IL-15 cells. Depletion of natural killer cells in nude mice with anti-asialo GM1 antibody did not influence the survival of the mice injected with Colon 26/IL-15 cells. Immunohistological examination revealed that CD31+ cells migrated into tumors of Colon 26/IL-15 cells that developed in immunocompetent and immunocompromised mice. Taken together, our results indicate that an inoculation of IL-15-producing tumor cells can produce antitumor effects that are mediated by a variety of immunocompetent cells.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>10770634</pmid><doi>10.1038/sj.cgt.7700112</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Antitumor activity Cell proliferation Clone Cells Colon Colonic Neoplasms - genetics Colonic Neoplasms - immunology Colonic Neoplasms - mortality Colonic Neoplasms - therapy Colorectal cancer Cytokines Female Genetic Vectors - secretion IL-15 gene Immunocompetence Immunocompetence - genetics Immunocompromised Host - genetics Immunocompromised hosts Immunodeficiency Immunohistochemistry Inoculation Interleukin 15 Interleukin-15 - genetics Interleukin-15 - secretion Interleukin-15 - therapeutic use Metastases Mice Mice, Inbred BALB C Mice, Nude Mice, SCID Natural killer cells Retroviridae - genetics Survival Analysis Transformation, Genetic - immunology Tumor cells Tumor Cells, Cultured - chemistry Tumor Cells, Cultured - immunology Tumor Cells, Cultured - secretion Tumors |
| title | Transduction of murine colon carcinoma cells with interleukin-15 gene induces antitumor effects in immunocompetent and immunocompromised hosts |
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