Selective attenuation of psychostimulant-induced behavioral responses in mice lacking A(2A) adenosine receptors

A(2A) adenosine receptors are highly expressed in the striatum where they modulate dopaminergic activity. The role of A(2A) receptors in psychostimulant action is less well understood because of the lack of A(2A)-selective compounds with access to the central nervous system. To investigate the A(2A)...

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Veröffentlicht in:	Neuroscience 2000-01, Vol.97 (1), p.195-204
Hauptverfasser:	Chen, J F, Beilstein, M, Xu, Y H, Turner, T J, Moratalla, R, Standaert, D G, Aloyo, V J, Fink, J S, Schwarzschild, M A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Behavior, Animal - physiology Brain - cytology Brain - drug effects Brain - metabolism Central Nervous System Stimulants - pharmacology Cocaine - pharmacology Dopamine - metabolism Dopamine Agonists - pharmacology Dopamine Uptake Inhibitors - pharmacology Genotype Locomotion - drug effects Locomotion - physiology Mice Mice, Knockout Neostriatum - cytology Neostriatum - drug effects Neostriatum - metabolism Phenotype Receptor, Adenosine A2A Receptors, Dopamine D1 - agonists Receptors, Dopamine D1 - analysis Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - agonists Receptors, Dopamine D2 - analysis Receptors, Dopamine D2 - metabolism Receptors, Purinergic P1 - deficiency Receptors, Purinergic P1 - drug effects Receptors, Purinergic P1 - genetics
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