Morphine Increases Susceptibility to Oral Salmonella typhimurium Infection
This study examined the effect of morphine on oral infection with virulent Salmonella typhimurium. Animals were treated with a 75-mg slow-release morphine pellet followed by inoculation with salmonellae. Morphine markedly sensitized mice to oral infection, as assessed by survival, mean survival time...
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| Veröffentlicht in: | The Journal of infectious diseases 2000-04, Vol.181 (4), p.1350-1358 |
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| container_title | The Journal of infectious diseases |
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| creator | MacFarlane, Amanda Shearer Peng, Xiaohui Meissler, Joseph J. Rogers, Thomas J. Geller, Ellen B. Adler, Martin W. Eisenstein, Toby K. |
| description | This study examined the effect of morphine on oral infection with virulent Salmonella typhimurium. Animals were treated with a 75-mg slow-release morphine pellet followed by inoculation with salmonellae. Morphine markedly sensitized mice to oral infection, as assessed by survival, mean survival time, and colony culture. By 24 h after Salmonella inoculation, morphine-treated mice had a 105-fold difference in number of organisms in the Peyer's patches, compared with controls. The opioid antagonist naltrexone significantly blocked Salmonella colonization in Peyer's patches and reduced Salmonella burden in other organs, indicating that morphine acts at least in part via an opioid receptor—mediated pathway. The data show that morphine markedly potentiates Salmonella infection at the gastrointestinal portal of entry and enhances subsequent dissemination of Salmonella organisms. The results have implications for potentiating gastrointestinal opportunistic infections in intravenous drug abusers and in opioid-medicated postsurgical patients. |
| doi_str_mv | 10.1086/315403 |
| format | Article |
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Animals were treated with a 75-mg slow-release morphine pellet followed by inoculation with salmonellae. Morphine markedly sensitized mice to oral infection, as assessed by survival, mean survival time, and colony culture. By 24 h after Salmonella inoculation, morphine-treated mice had a 105-fold difference in number of organisms in the Peyer's patches, compared with controls. The opioid antagonist naltrexone significantly blocked Salmonella colonization in Peyer's patches and reduced Salmonella burden in other organs, indicating that morphine acts at least in part via an opioid receptor—mediated pathway. The data show that morphine markedly potentiates Salmonella infection at the gastrointestinal portal of entry and enhances subsequent dissemination of Salmonella organisms. The results have implications for potentiating gastrointestinal opportunistic infections in intravenous drug abusers and in opioid-medicated postsurgical patients.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/315403</identifier><identifier>PMID: 10762566</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Animals ; Bacteria ; Biological and medical sciences ; Cytokines - biosynthesis ; Cytokines - genetics ; Disease Susceptibility ; Dosage ; Drug toxicity and drugs side effects treatment ; Female ; Germ-Free Life ; Infections ; Inoculation ; Major Article ; Medical sciences ; Mice ; Mice, Inbred C3H ; Morphine ; Morphine - pharmacology ; Mouth - microbiology ; Mouth Diseases - etiology ; Mouth Diseases - microbiology ; Naltrexone - pharmacology ; Nitric Oxide Synthase - biosynthesis ; Nitric Oxide Synthase - genetics ; Nitric Oxide Synthase Type II ; Opioid analgesics ; Peyer's Patches - microbiology ; Pharmacology. Drug treatments ; Placebos ; Plasmids ; RNA, Messenger - biosynthesis ; Salmonella ; Salmonella infections ; Salmonella Infections, Animal - etiology ; Salmonella typhimurium ; Toxicity: digestive system</subject><ispartof>The Journal of infectious diseases, 2000-04, Vol.181 (4), p.1350-1358</ispartof><rights>Copyright 2000 Infectious Diseases Society of America</rights><rights>2000 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Apr 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-4af9f11d803dea0c51240faa2791ab6507c0b2e7db25148e1ffc5405a54bdbdc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30109147$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30109147$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1476205$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10762566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MacFarlane, Amanda Shearer</creatorcontrib><creatorcontrib>Peng, Xiaohui</creatorcontrib><creatorcontrib>Meissler, Joseph J.</creatorcontrib><creatorcontrib>Rogers, Thomas J.</creatorcontrib><creatorcontrib>Geller, Ellen B.</creatorcontrib><creatorcontrib>Adler, Martin W.</creatorcontrib><creatorcontrib>Eisenstein, Toby K.</creatorcontrib><title>Morphine Increases Susceptibility to Oral Salmonella typhimurium Infection</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>This study examined the effect of morphine on oral infection with virulent Salmonella typhimurium. Animals were treated with a 75-mg slow-release morphine pellet followed by inoculation with salmonellae. Morphine markedly sensitized mice to oral infection, as assessed by survival, mean survival time, and colony culture. By 24 h after Salmonella inoculation, morphine-treated mice had a 105-fold difference in number of organisms in the Peyer's patches, compared with controls. The opioid antagonist naltrexone significantly blocked Salmonella colonization in Peyer's patches and reduced Salmonella burden in other organs, indicating that morphine acts at least in part via an opioid receptor—mediated pathway. The data show that morphine markedly potentiates Salmonella infection at the gastrointestinal portal of entry and enhances subsequent dissemination of Salmonella organisms. The results have implications for potentiating gastrointestinal opportunistic infections in intravenous drug abusers and in opioid-medicated postsurgical patients.</description><subject>Animals</subject><subject>Bacteria</subject><subject>Biological and medical sciences</subject><subject>Cytokines - biosynthesis</subject><subject>Cytokines - genetics</subject><subject>Disease Susceptibility</subject><subject>Dosage</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Germ-Free Life</subject><subject>Infections</subject><subject>Inoculation</subject><subject>Major Article</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Morphine</subject><subject>Morphine - pharmacology</subject><subject>Mouth - microbiology</subject><subject>Mouth Diseases - etiology</subject><subject>Mouth Diseases - microbiology</subject><subject>Naltrexone - pharmacology</subject><subject>Nitric Oxide Synthase - biosynthesis</subject><subject>Nitric Oxide Synthase - genetics</subject><subject>Nitric Oxide Synthase Type II</subject><subject>Opioid analgesics</subject><subject>Peyer's Patches - microbiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Placebos</subject><subject>Plasmids</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Salmonella</subject><subject>Salmonella infections</subject><subject>Salmonella Infections, Animal - etiology</subject><subject>Salmonella typhimurium</subject><subject>Toxicity: digestive system</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1TAQhS0EopcC_wAUIcQuMONnsqwqoEVFRSqPqhvLcRzhSxJfbEfi_nuMctUiNqxmcb45OnOGkKcIrxEa-Yah4MDukQ0Kpmopkd0nGwBKa2za9og8SmkLAJxJ9ZAcIShJhZQb8uFjiLvvfnbV-WyjM8ml6mpJ1u2y7_zo877KobqMZqyuzDiF2Y2jqfK-7ExL9MtU9gZnsw_zY_JgMGNyTw7zmHx59_bz6Vl9cfn-_PTkorZcyVxzM7QDYt8A650BK5ByGIyhqkXTSQHKQked6jsqkDcOh8GW24QRvOu73rJj8mr13cXwc3Ep68mXwCXX7MKStELgsgH4L4gNNAJaLOCLf8BtWOJcjtCUshYlA7xzszGkFN2gd9FPJu41gv7zA73-oIDPD25LN7n-L2wtvQAvD4BJ1oxDNLP16Y4rNVEQBXu2YtuUQ7yVS5aSmaui16vuU3a_bnUTf2ipmBL67PpGf6NfG3V9w_Qn9huMRqVl</recordid><startdate>20000401</startdate><enddate>20000401</enddate><creator>MacFarlane, Amanda Shearer</creator><creator>Peng, Xiaohui</creator><creator>Meissler, Joseph J.</creator><creator>Rogers, Thomas J.</creator><creator>Geller, Ellen B.</creator><creator>Adler, Martin W.</creator><creator>Eisenstein, Toby K.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20000401</creationdate><title>Morphine Increases Susceptibility to Oral Salmonella typhimurium Infection</title><author>MacFarlane, Amanda Shearer ; Peng, Xiaohui ; Meissler, Joseph J. ; Rogers, Thomas J. ; Geller, Ellen B. ; Adler, Martin W. ; Eisenstein, Toby K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-4af9f11d803dea0c51240faa2791ab6507c0b2e7db25148e1ffc5405a54bdbdc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Bacteria</topic><topic>Biological and medical sciences</topic><topic>Cytokines - biosynthesis</topic><topic>Cytokines - genetics</topic><topic>Disease Susceptibility</topic><topic>Dosage</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Germ-Free Life</topic><topic>Infections</topic><topic>Inoculation</topic><topic>Major Article</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Morphine</topic><topic>Morphine - pharmacology</topic><topic>Mouth - microbiology</topic><topic>Mouth Diseases - etiology</topic><topic>Mouth Diseases - microbiology</topic><topic>Naltrexone - pharmacology</topic><topic>Nitric Oxide Synthase - biosynthesis</topic><topic>Nitric Oxide Synthase - genetics</topic><topic>Nitric Oxide Synthase Type II</topic><topic>Opioid analgesics</topic><topic>Peyer's Patches - microbiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Placebos</topic><topic>Plasmids</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Salmonella</topic><topic>Salmonella infections</topic><topic>Salmonella Infections, Animal - etiology</topic><topic>Salmonella typhimurium</topic><topic>Toxicity: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MacFarlane, Amanda Shearer</creatorcontrib><creatorcontrib>Peng, Xiaohui</creatorcontrib><creatorcontrib>Meissler, Joseph J.</creatorcontrib><creatorcontrib>Rogers, Thomas J.</creatorcontrib><creatorcontrib>Geller, Ellen B.</creatorcontrib><creatorcontrib>Adler, Martin W.</creatorcontrib><creatorcontrib>Eisenstein, Toby K.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MacFarlane, Amanda Shearer</au><au>Peng, Xiaohui</au><au>Meissler, Joseph J.</au><au>Rogers, Thomas J.</au><au>Geller, Ellen B.</au><au>Adler, Martin W.</au><au>Eisenstein, Toby K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphine Increases Susceptibility to Oral Salmonella typhimurium Infection</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2000-04-01</date><risdate>2000</risdate><volume>181</volume><issue>4</issue><spage>1350</spage><epage>1358</epage><pages>1350-1358</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>This study examined the effect of morphine on oral infection with virulent Salmonella typhimurium. Animals were treated with a 75-mg slow-release morphine pellet followed by inoculation with salmonellae. Morphine markedly sensitized mice to oral infection, as assessed by survival, mean survival time, and colony culture. By 24 h after Salmonella inoculation, morphine-treated mice had a 105-fold difference in number of organisms in the Peyer's patches, compared with controls. The opioid antagonist naltrexone significantly blocked Salmonella colonization in Peyer's patches and reduced Salmonella burden in other organs, indicating that morphine acts at least in part via an opioid receptor—mediated pathway. The data show that morphine markedly potentiates Salmonella infection at the gastrointestinal portal of entry and enhances subsequent dissemination of Salmonella organisms. The results have implications for potentiating gastrointestinal opportunistic infections in intravenous drug abusers and in opioid-medicated postsurgical patients.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>10762566</pmid><doi>10.1086/315403</doi><tpages>9</tpages></addata></record> |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Animals Bacteria Biological and medical sciences Cytokines - biosynthesis Cytokines - genetics Disease Susceptibility Dosage Drug toxicity and drugs side effects treatment Female Germ-Free Life Infections Inoculation Major Article Medical sciences Mice Mice, Inbred C3H Morphine Morphine - pharmacology Mouth - microbiology Mouth Diseases - etiology Mouth Diseases - microbiology Naltrexone - pharmacology Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II Opioid analgesics Peyer's Patches - microbiology Pharmacology. Drug treatments Placebos Plasmids RNA, Messenger - biosynthesis Salmonella Salmonella infections Salmonella Infections, Animal - etiology Salmonella typhimurium Toxicity: digestive system |
| title | Morphine Increases Susceptibility to Oral Salmonella typhimurium Infection |
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