The leukaemic oncoproteins Bcr-Abl and Tel-Abl (ETV6/Abl) have altered substrate preferences and activate similar intracellular signalling pathways

Inappropriate activation of Abl family kinases plays a crucial role in different human leukaemias. In addition to the well known oncoproteins p190Bcr-Abl and p210Bcr-Abl, Tel-Abl, a novel fusion protein resulting from a different chromosomal translocation, has recently been described. In this study,...

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Veröffentlicht in:	Oncogene 2000-03, Vol.19 (13), p.1684-1690
Hauptverfasser:	VOSS, J, POSERN, G, HANNEMANN, J. R, WIEDEMANN, L. M, TURHAN, A. G, POIREL, H, BERNARD, O. A, ADERMANN, K, KARDINAL, C, FELLER, S. M
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Abl protein Adapter proteins Adaptor Proteins, Signal Transducing AKT protein Amino Acid Sequence Animals Apoptosis BCR protein BCR-ABL protein Biological and medical sciences Catalysis Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular signal transduction Chromosome translocations Chromosomes Epitopes Epitopes - metabolism Extracellular signal-regulated kinase Fundamental and applied biological sciences. Psychology Fusion protein Genetic aspects GTP Phosphohydrolases - metabolism GTP-binding protein Guanosine Triphosphate - physiology Hematopoietic Stem Cells Humans Intracellular signalling Kinases Leukemia Macromolecular Substances MAP kinase MAP Kinase Signaling System Medical research Mice Molecular and cellular biology Molecular Sequence Data Nuclear Proteins - metabolism Oncogene Proteins, Fusion - metabolism Oncoproteins Peptide Fragments - chemical synthesis Peptide Fragments - chemistry Peptide Fragments - metabolism Peptides Phosphorylation Physiological aspects Protein Processing, Post-Translational Protein tyrosine kinase Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-abl - metabolism Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-crk Proto-Oncogene Proteins p21(ras) - metabolism RNA polymerase Signal transduction Substrate preferences Substrate Specificity Translocation, Genetic Tumor proteins Tyrosine
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