First Atropo-Divergent Total Synthesis of the Antimalarial Korupensamines A and B by the “Lactone Method”

The stereoselective total synthesis of the antimalarial korupensamines A (1a) and B (1b) by application of the “lactone method” is described. Key steps of this first atropo-selective access to 5,8‘-coupled naphthylisoquinoline alkaloids were the regioselective intramolecular coupling of ester 8 to g...

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Veröffentlicht in:	Journal of organic chemistry 2000-04, Vol.65 (7), p.2069-2077
Hauptverfasser:	Bringmann, Gerhard, Ochse, Michael, Götz, Roland
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - chemical synthesis Catalysis Chromatography, High Pressure Liquid Isoquinolines - chemical synthesis Lactones - chemistry Magnetic Resonance Spectroscopy Naphthalenes - chemical synthesis Palladium Plants, Medicinal - chemistry Spectrophotometry, Ultraviolet Stereoisomerism
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