Disseminated intravascular coagulation
Healthy pregnancy is accompanied by changes in the haemostatic system which convert it into a hypercoagulable state vulnerable to a spectrum of disorders ranging from venous thromboembolism to disseminated intravascular coagulation (DIC). This latter is always a secondary phenomenon triggered by spe...
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description | Healthy pregnancy is accompanied by changes in the haemostatic system which convert it into a hypercoagulable state vulnerable to a spectrum of disorders ranging from venous thromboembolism to disseminated intravascular coagulation (DIC). This latter is always a secondary phenomenon triggered by specific disorders such as abruptio placentae and amniotic fluid embolism due to release of thromboplastin intravascularly or endothelial damage resulting from pre-eclampsia and sepsis. In modern obstetric practice the most common cause is haemorrhagic shock with delay in resuscitation leading to endothelial damage. The initial management of massive obstetric haemorrhage is the same whether associated with coagulopathy initially or not. Low-grade DIC, associated with pre-eclampsia, is monitored haematologically by serial platelet counts and serum fibrin degradation products (FDPs). Supportive measures and removal of the triggering mechanism are the key to successful management. Outcome depends primarily on our ability to deal with the trigger and not on direct attempts to correct the coagulation deficit. |
doi_str_mv | 10.1053/beog.2001.0204 |
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This latter is always a secondary phenomenon triggered by specific disorders such as abruptio placentae and amniotic fluid embolism due to release of thromboplastin intravascularly or endothelial damage resulting from pre-eclampsia and sepsis. In modern obstetric practice the most common cause is haemorrhagic shock with delay in resuscitation leading to endothelial damage. The initial management of massive obstetric haemorrhage is the same whether associated with coagulopathy initially or not. Low-grade DIC, associated with pre-eclampsia, is monitored haematologically by serial platelet counts and serum fibrin degradation products (FDPs). Supportive measures and removal of the triggering mechanism are the key to successful management. Outcome depends primarily on our ability to deal with the trigger and not on direct attempts to correct the coagulation deficit.</description><identifier>ISSN: 1521-6934</identifier><identifier>EISSN: 1532-1932</identifier><identifier>DOI: 10.1053/beog.2001.0204</identifier><identifier>PMID: 11478819</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Abortion, Therapeutic - adverse effects ; abruptio placentae ; Abruptio Placentae - complications ; Abruptio Placentae - physiopathology ; Abruptio Placentae - therapy ; amniotic fluid embolism ; Blood Transfusion ; coagulopathy ; Disseminated Intravascular Coagulation - etiology ; Disseminated Intravascular Coagulation - physiopathology ; Disseminated Intravascular Coagulation - therapy ; Embolism, Amniotic Fluid - complications ; Embolism, Amniotic Fluid - physiopathology ; Embolism, Amniotic Fluid - therapy ; Embolization, Therapeutic ; Fatty Liver - complications ; Fatty Liver - physiopathology ; Fatty Liver - therapy ; Female ; Fetal Death - complications ; Fetal Death - physiopathology ; Fetal Death - therapy ; fibrinolysis ; haemostatis ; Hemolytic-Uremic Syndrome - complications ; Hemolytic-Uremic Syndrome - physiopathology ; Hemolytic-Uremic Syndrome - therapy ; Humans ; low-grade DIC ; massive haemorrhage ; Placenta Accreta - complications ; Placenta Accreta - physiopathology ; Placenta Accreta - therapy ; Plasma ; Plasma Substitutes - therapeutic use ; pre-eclampsia ; Pre-Eclampsia - complications ; Pre-Eclampsia - physiopathology ; Pre-Eclampsia - therapy ; Pregnancy ; Pregnancy Complications, Cardiovascular - etiology ; Pregnancy Complications, Cardiovascular - physiopathology ; Pregnancy Complications, Cardiovascular - therapy ; Purpura, Schoenlein-Henoch - complications ; Purpura, Schoenlein-Henoch - physiopathology ; Purpura, Schoenlein-Henoch - therapy ; sepsis ; transfusion</subject><ispartof>Best practice & research. Clinical obstetrics & gynaecology, 2001-08, Vol.15 (4), p.623-644</ispartof><rights>2001 Harcourt Publishers Ltd</rights><rights>Copyright 2001 Harcourt Publishers Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-94e16bf007deece3b6399d2c5afa33acf78da19f8088d6d11942e412c20994423</citedby><cites>FETCH-LOGICAL-c340t-94e16bf007deece3b6399d2c5afa33acf78da19f8088d6d11942e412c20994423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1053/beog.2001.0204$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11478819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Letsky, Elizabeth A.</creatorcontrib><title>Disseminated intravascular coagulation</title><title>Best practice & research. Clinical obstetrics & gynaecology</title><addtitle>Best Pract Res Clin Obstet Gynaecol</addtitle><description>Healthy pregnancy is accompanied by changes in the haemostatic system which convert it into a hypercoagulable state vulnerable to a spectrum of disorders ranging from venous thromboembolism to disseminated intravascular coagulation (DIC). This latter is always a secondary phenomenon triggered by specific disorders such as abruptio placentae and amniotic fluid embolism due to release of thromboplastin intravascularly or endothelial damage resulting from pre-eclampsia and sepsis. In modern obstetric practice the most common cause is haemorrhagic shock with delay in resuscitation leading to endothelial damage. The initial management of massive obstetric haemorrhage is the same whether associated with coagulopathy initially or not. Low-grade DIC, associated with pre-eclampsia, is monitored haematologically by serial platelet counts and serum fibrin degradation products (FDPs). Supportive measures and removal of the triggering mechanism are the key to successful management. Outcome depends primarily on our ability to deal with the trigger and not on direct attempts to correct the coagulation deficit.</description><subject>Abortion, Therapeutic - adverse effects</subject><subject>abruptio placentae</subject><subject>Abruptio Placentae - complications</subject><subject>Abruptio Placentae - physiopathology</subject><subject>Abruptio Placentae - therapy</subject><subject>amniotic fluid embolism</subject><subject>Blood Transfusion</subject><subject>coagulopathy</subject><subject>Disseminated Intravascular Coagulation - etiology</subject><subject>Disseminated Intravascular Coagulation - physiopathology</subject><subject>Disseminated Intravascular Coagulation - therapy</subject><subject>Embolism, Amniotic Fluid - complications</subject><subject>Embolism, Amniotic Fluid - physiopathology</subject><subject>Embolism, Amniotic Fluid - therapy</subject><subject>Embolization, Therapeutic</subject><subject>Fatty Liver - complications</subject><subject>Fatty Liver - physiopathology</subject><subject>Fatty Liver - therapy</subject><subject>Female</subject><subject>Fetal Death - complications</subject><subject>Fetal Death - physiopathology</subject><subject>Fetal Death - therapy</subject><subject>fibrinolysis</subject><subject>haemostatis</subject><subject>Hemolytic-Uremic Syndrome - complications</subject><subject>Hemolytic-Uremic Syndrome - physiopathology</subject><subject>Hemolytic-Uremic Syndrome - therapy</subject><subject>Humans</subject><subject>low-grade DIC</subject><subject>massive haemorrhage</subject><subject>Placenta Accreta - complications</subject><subject>Placenta Accreta - physiopathology</subject><subject>Placenta Accreta - therapy</subject><subject>Plasma</subject><subject>Plasma Substitutes - therapeutic use</subject><subject>pre-eclampsia</subject><subject>Pre-Eclampsia - complications</subject><subject>Pre-Eclampsia - physiopathology</subject><subject>Pre-Eclampsia - therapy</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Cardiovascular - etiology</subject><subject>Pregnancy Complications, Cardiovascular - physiopathology</subject><subject>Pregnancy Complications, Cardiovascular - therapy</subject><subject>Purpura, Schoenlein-Henoch - complications</subject><subject>Purpura, Schoenlein-Henoch - physiopathology</subject><subject>Purpura, Schoenlein-Henoch - therapy</subject><subject>sepsis</subject><subject>transfusion</subject><issn>1521-6934</issn><issn>1532-1932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAUhS0EoqWwMqJO3RLutZ00HlF5SpVYYLYc-6YyyqPYSSX-PYlaiYnpnuE7R7ofY7cIKUIm7kvqdikHwBQ4yDM2x0zwBJXg51PmmORKyBm7ivELQAjFs0s2Q5TrokA1Z6tHHyM1vjU9uaVv-2AOJtqhNmFpO7MbQ--79ppdVKaOdHO6C_b5_PSxeU227y9vm4dtYoWEPlGSMC8rgLUjsiTKXCjluM1MZYQwtloXzqCqCigKlztEJTlJ5JaDUlJysWCr4-4-dN8DxV43Plqqa9NSN0S9RhixbALTI2hDF2OgSu-Db0z40Qh6MqMnM3oyoyczY-HutDyUDbk__KRiBIojQON_B09BR-upteR8INtr1_n_tn8BGdxxWQ</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>Letsky, Elizabeth A.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010801</creationdate><title>Disseminated intravascular coagulation</title><author>Letsky, Elizabeth A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-94e16bf007deece3b6399d2c5afa33acf78da19f8088d6d11942e412c20994423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Abortion, Therapeutic - adverse effects</topic><topic>abruptio placentae</topic><topic>Abruptio Placentae - complications</topic><topic>Abruptio Placentae - physiopathology</topic><topic>Abruptio Placentae - therapy</topic><topic>amniotic fluid embolism</topic><topic>Blood Transfusion</topic><topic>coagulopathy</topic><topic>Disseminated Intravascular Coagulation - etiology</topic><topic>Disseminated Intravascular Coagulation - physiopathology</topic><topic>Disseminated Intravascular Coagulation - therapy</topic><topic>Embolism, Amniotic Fluid - complications</topic><topic>Embolism, Amniotic Fluid - physiopathology</topic><topic>Embolism, Amniotic Fluid - therapy</topic><topic>Embolization, Therapeutic</topic><topic>Fatty Liver - complications</topic><topic>Fatty Liver - physiopathology</topic><topic>Fatty Liver - therapy</topic><topic>Female</topic><topic>Fetal Death - complications</topic><topic>Fetal Death - physiopathology</topic><topic>Fetal Death - therapy</topic><topic>fibrinolysis</topic><topic>haemostatis</topic><topic>Hemolytic-Uremic Syndrome - complications</topic><topic>Hemolytic-Uremic Syndrome - physiopathology</topic><topic>Hemolytic-Uremic Syndrome - therapy</topic><topic>Humans</topic><topic>low-grade DIC</topic><topic>massive haemorrhage</topic><topic>Placenta Accreta - complications</topic><topic>Placenta Accreta - physiopathology</topic><topic>Placenta Accreta - therapy</topic><topic>Plasma</topic><topic>Plasma Substitutes - therapeutic use</topic><topic>pre-eclampsia</topic><topic>Pre-Eclampsia - complications</topic><topic>Pre-Eclampsia - physiopathology</topic><topic>Pre-Eclampsia - therapy</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Cardiovascular - etiology</topic><topic>Pregnancy Complications, Cardiovascular - physiopathology</topic><topic>Pregnancy Complications, Cardiovascular - therapy</topic><topic>Purpura, Schoenlein-Henoch - complications</topic><topic>Purpura, Schoenlein-Henoch - physiopathology</topic><topic>Purpura, Schoenlein-Henoch - therapy</topic><topic>sepsis</topic><topic>transfusion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Letsky, Elizabeth A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Best practice & research. Clinical obstetrics & gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Letsky, Elizabeth A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disseminated intravascular coagulation</atitle><jtitle>Best practice & research. Clinical obstetrics & gynaecology</jtitle><addtitle>Best Pract Res Clin Obstet Gynaecol</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>15</volume><issue>4</issue><spage>623</spage><epage>644</epage><pages>623-644</pages><issn>1521-6934</issn><eissn>1532-1932</eissn><abstract>Healthy pregnancy is accompanied by changes in the haemostatic system which convert it into a hypercoagulable state vulnerable to a spectrum of disorders ranging from venous thromboembolism to disseminated intravascular coagulation (DIC). This latter is always a secondary phenomenon triggered by specific disorders such as abruptio placentae and amniotic fluid embolism due to release of thromboplastin intravascularly or endothelial damage resulting from pre-eclampsia and sepsis. In modern obstetric practice the most common cause is haemorrhagic shock with delay in resuscitation leading to endothelial damage. The initial management of massive obstetric haemorrhage is the same whether associated with coagulopathy initially or not. Low-grade DIC, associated with pre-eclampsia, is monitored haematologically by serial platelet counts and serum fibrin degradation products (FDPs). Supportive measures and removal of the triggering mechanism are the key to successful management. Outcome depends primarily on our ability to deal with the trigger and not on direct attempts to correct the coagulation deficit.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>11478819</pmid><doi>10.1053/beog.2001.0204</doi><tpages>22</tpages></addata></record> |
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subjects | Abortion, Therapeutic - adverse effects abruptio placentae Abruptio Placentae - complications Abruptio Placentae - physiopathology Abruptio Placentae - therapy amniotic fluid embolism Blood Transfusion coagulopathy Disseminated Intravascular Coagulation - etiology Disseminated Intravascular Coagulation - physiopathology Disseminated Intravascular Coagulation - therapy Embolism, Amniotic Fluid - complications Embolism, Amniotic Fluid - physiopathology Embolism, Amniotic Fluid - therapy Embolization, Therapeutic Fatty Liver - complications Fatty Liver - physiopathology Fatty Liver - therapy Female Fetal Death - complications Fetal Death - physiopathology Fetal Death - therapy fibrinolysis haemostatis Hemolytic-Uremic Syndrome - complications Hemolytic-Uremic Syndrome - physiopathology Hemolytic-Uremic Syndrome - therapy Humans low-grade DIC massive haemorrhage Placenta Accreta - complications Placenta Accreta - physiopathology Placenta Accreta - therapy Plasma Plasma Substitutes - therapeutic use pre-eclampsia Pre-Eclampsia - complications Pre-Eclampsia - physiopathology Pre-Eclampsia - therapy Pregnancy Pregnancy Complications, Cardiovascular - etiology Pregnancy Complications, Cardiovascular - physiopathology Pregnancy Complications, Cardiovascular - therapy Purpura, Schoenlein-Henoch - complications Purpura, Schoenlein-Henoch - physiopathology Purpura, Schoenlein-Henoch - therapy sepsis transfusion |
title | Disseminated intravascular coagulation |
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