Human immunodeficiency virus type 1 can infect human retinal pigment epithelial cells in culture and alter the ability of the cells to phagocytose rod outer segment membranes

Human immunodeficiency virus type 1 (HIV-1) has been found in the vitreous of persons with AIDS. Here we investigated the susceptibility of human retinal pigment epithelial (RPE) cells to HIV-1 infection in culture and the effects of HIV-1 on the phagocytic function of the RPE. We found that 10 of 1...

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Veröffentlicht in:	AIDS research and human retroviruses 2000-03, Vol.16 (5), p.453-463
Hauptverfasser:	CANKI, M, SPARROW, J. R, WEI CHAO, POTASH, M. J, VOLSKY, D. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS/HIV Animals Biological and medical sciences CD4 Antigens - pharmacology Cell Fusion Cells, Cultured CHO Cells Cricetinae DNA, Viral - analysis Epithelial Cells - virology Fetus Fundamental and applied biological sciences. Psychology glycoprotein gp120 HIV Envelope Protein gp120 - metabolism HIV-1 - drug effects HIV-1 - isolation & purification HIV-1 - physiology Human immunodeficiency virus 1 Humans Microbiology Phagocytosis Pigment Epithelium of Eye - immunology Pigment Epithelium of Eye - metabolism Pigment Epithelium of Eye - virology Polymerase Chain Reaction Recombinant Proteins - pharmacology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains RNA, Viral - analysis Rod Cell Outer Segment - immunology RPE cells Virology Virus Replication
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