In vivo indomethacin treatment causes microglial activation in adult mice

The current study was undertaken to study the role of prostaglandins in regulating microglial activation. Mice were treated with indomethacin (2 microg/ml) in their drinking water to selectively inhibit cyclooxygenase activity. After 4-8 days, the effect of inhibiting prostaglandin synthesis on micr...

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Veröffentlicht in:	Neurochemical research 2000-03, Vol.25 (3), p.357-362
Hauptverfasser:	PRECHEL, M. Margaret, DING, Charley, WASHINGTON, Remy L, KOLODZIEJ, Meghan S, YOUNG, M. Rita
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cyclooxygenase Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology In Vitro Techniques indomethacin Indomethacin - pharmacology Isolated neuron and nerve. Neuroglia Macrophage-1 Antigen - metabolism Mice Mice, Inbred C57BL Microglia - drug effects Microglia - metabolism Prostaglandins - biosynthesis Vertebrates: nervous system and sense organs
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