Clinical Features of Nipah Virus Encephalitis among Pig Farmers in Malaysia
Between September 1998 and June 1999, there was an outbreak of febrile encephalitis in several pig-farming villages in Malaysia. More than 200 patients were admitted to hospitals nationwide, many of whom died. 1 – 3 The pig-farming industry was disrupted by the culling of many pigs to control the ou...
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Veröffentlicht in: | The New England journal of medicine 2000-04, Vol.342 (17), p.1229-1235 |
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creator | Goh, Khean Jin Tan, Patrick Seow Koon Tan, Chong Tin Chew, Nee Kong Kamarulzaman, Adeeba Sarji, Sazilah Ahmad Wong, Kum Thong Abdullah, Basri Johan Jeet Chua, Kaw Bing Lam, Sai Kit |
description | Between September 1998 and June 1999, there was an outbreak of febrile encephalitis in several pig-farming villages in Malaysia. More than 200 patients were admitted to hospitals nationwide, many of whom died.
1
–
3
The pig-farming industry was disrupted by the culling of many pigs to control the outbreak and the closing of farms. Several abattoir workers in neighboring Singapore were also affected.
4
,
5
Japanese encephalitis, a viral encephalitis associated with pigs that is endemic in Southeast Asia, was initially suspected, but clinical and epidemiologic features suggested that a different disease was responsible.
The isolation of a new paramyxovirus, subsequently named . . . |
doi_str_mv | 10.1056/NEJM200004273421701 |
format | Article |
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1
–
3
The pig-farming industry was disrupted by the culling of many pigs to control the outbreak and the closing of farms. Several abattoir workers in neighboring Singapore were also affected.
4
,
5
Japanese encephalitis, a viral encephalitis associated with pigs that is endemic in Southeast Asia, was initially suspected, but clinical and epidemiologic features suggested that a different disease was responsible.
The isolation of a new paramyxovirus, subsequently named . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM200004273421701</identifier><identifier>PMID: 10781618</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adult ; Animal Husbandry ; Animals ; Antibodies, Viral - blood ; Antibodies, Viral - cerebrospinal fluid ; Cerebrospinal Fluid - chemistry ; Cerebrospinal Fluid - immunology ; Disease Outbreaks - statistics & numerical data ; Electroencephalography ; Encephalitis ; Encephalitis, Viral - epidemiology ; Encephalitis, Viral - mortality ; Encephalitis, Viral - physiopathology ; Encephalitis, Viral - virology ; Female ; Hogs ; Humans ; Logistic Models ; Magnetic Resonance Imaging ; Malaysia ; Malaysia - epidemiology ; Male ; Nervous System Diseases - etiology ; Nipah virus ; NMR ; Nuclear magnetic resonance ; Paramyxoviridae Infections - complications ; Paramyxoviridae Infections - epidemiology ; Paramyxoviridae Infections - mortality ; Paramyxoviridae Infections - physiopathology ; Paramyxovirinae - immunology ; pigs ; Recurrence ; Swine</subject><ispartof>The New England journal of medicine, 2000-04, Vol.342 (17), p.1229-1235</ispartof><rights>Copyright © 2000 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c647t-f307e3cba27e2d20d58ae64f4928c289e3354bf8248fea7899928dadab0715103</citedby><cites>FETCH-LOGICAL-c647t-f307e3cba27e2d20d58ae64f4928c289e3354bf8248fea7899928dadab0715103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM200004273421701$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223941904?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,782,786,2761,2762,26110,27931,27932,52389,54071,64392,64394,64396,72476</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10781618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goh, Khean Jin</creatorcontrib><creatorcontrib>Tan, Patrick Seow Koon</creatorcontrib><creatorcontrib>Tan, Chong Tin</creatorcontrib><creatorcontrib>Chew, Nee Kong</creatorcontrib><creatorcontrib>Kamarulzaman, Adeeba</creatorcontrib><creatorcontrib>Sarji, Sazilah Ahmad</creatorcontrib><creatorcontrib>Wong, Kum Thong</creatorcontrib><creatorcontrib>Abdullah, Basri Johan Jeet</creatorcontrib><creatorcontrib>Chua, Kaw Bing</creatorcontrib><creatorcontrib>Lam, Sai Kit</creatorcontrib><title>Clinical Features of Nipah Virus Encephalitis among Pig Farmers in Malaysia</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Between September 1998 and June 1999, there was an outbreak of febrile encephalitis in several pig-farming villages in Malaysia. More than 200 patients were admitted to hospitals nationwide, many of whom died.
1
–
3
The pig-farming industry was disrupted by the culling of many pigs to control the outbreak and the closing of farms. Several abattoir workers in neighboring Singapore were also affected.
4
,
5
Japanese encephalitis, a viral encephalitis associated with pigs that is endemic in Southeast Asia, was initially suspected, but clinical and epidemiologic features suggested that a different disease was responsible.
The isolation of a new paramyxovirus, subsequently named . . .</description><subject>Adult</subject><subject>Animal Husbandry</subject><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>Antibodies, Viral - cerebrospinal fluid</subject><subject>Cerebrospinal Fluid - chemistry</subject><subject>Cerebrospinal Fluid - immunology</subject><subject>Disease Outbreaks - statistics & numerical data</subject><subject>Electroencephalography</subject><subject>Encephalitis</subject><subject>Encephalitis, Viral - epidemiology</subject><subject>Encephalitis, Viral - mortality</subject><subject>Encephalitis, Viral - physiopathology</subject><subject>Encephalitis, Viral - virology</subject><subject>Female</subject><subject>Hogs</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Magnetic Resonance Imaging</subject><subject>Malaysia</subject><subject>Malaysia - epidemiology</subject><subject>Male</subject><subject>Nervous System Diseases - etiology</subject><subject>Nipah virus</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Paramyxoviridae Infections - complications</subject><subject>Paramyxoviridae Infections - epidemiology</subject><subject>Paramyxoviridae Infections - mortality</subject><subject>Paramyxoviridae Infections - physiopathology</subject><subject>Paramyxovirinae - immunology</subject><subject>pigs</subject><subject>Recurrence</subject><subject>Swine</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0btOwzAUBmALgWi5PAESshhYUMDHdmJ7RFXLrS0MwBqdJk5xlUuxm6FvT6p2QAiBlzP4O7909BNyBuwaWJzcTIePE866J7kSkoNisEf6EAsRScmSfdJnjOtIKiN65CiExcaCNIekB0xpSED3ydOgdLXLsKQji6vW20Cbgk7dEj_ou_NtoMM6s8sPLN3KBYpVU8_pi5vTEfrK-kBdTSdY4jo4PCEHBZbBnu7mMXkbDV8H99H4-e5hcDuOskSqVVQIpqzIZsiV5TlneazRJrKQhuuMa2OFiOWs0FzqwqLSxnQfOeY4YwpiYOKYXG5zl775bG1YpZULmS1LrG3ThlQBk6C1-ReCikGreAMvfsBF0_q6OyLlXBgJhskOiS3KfBOCt0W69K5Cv06BpZtG0l8a6bbOd9HtrLL5t51tBR242oKqCmltF9WfcV_swJAR</recordid><startdate>20000427</startdate><enddate>20000427</enddate><creator>Goh, Khean Jin</creator><creator>Tan, Patrick Seow Koon</creator><creator>Tan, Chong Tin</creator><creator>Chew, Nee Kong</creator><creator>Kamarulzaman, Adeeba</creator><creator>Sarji, Sazilah Ahmad</creator><creator>Wong, Kum Thong</creator><creator>Abdullah, Basri Johan Jeet</creator><creator>Chua, Kaw Bing</creator><creator>Lam, Sai Kit</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20000427</creationdate><title>Clinical Features of Nipah Virus Encephalitis among Pig Farmers in Malaysia</title><author>Goh, Khean Jin ; Tan, Patrick Seow Koon ; Tan, Chong Tin ; Chew, Nee Kong ; Kamarulzaman, Adeeba ; Sarji, Sazilah Ahmad ; Wong, Kum Thong ; Abdullah, Basri Johan Jeet ; Chua, Kaw Bing ; Lam, Sai Kit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c647t-f307e3cba27e2d20d58ae64f4928c289e3354bf8248fea7899928dadab0715103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Animal Husbandry</topic><topic>Animals</topic><topic>Antibodies, Viral - blood</topic><topic>Antibodies, Viral - cerebrospinal fluid</topic><topic>Cerebrospinal Fluid - chemistry</topic><topic>Cerebrospinal Fluid - immunology</topic><topic>Disease Outbreaks - statistics & numerical data</topic><topic>Electroencephalography</topic><topic>Encephalitis</topic><topic>Encephalitis, Viral - epidemiology</topic><topic>Encephalitis, Viral - mortality</topic><topic>Encephalitis, Viral - physiopathology</topic><topic>Encephalitis, Viral - virology</topic><topic>Female</topic><topic>Hogs</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Magnetic Resonance Imaging</topic><topic>Malaysia</topic><topic>Malaysia - epidemiology</topic><topic>Male</topic><topic>Nervous System Diseases - etiology</topic><topic>Nipah virus</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Paramyxoviridae Infections - complications</topic><topic>Paramyxoviridae Infections - epidemiology</topic><topic>Paramyxoviridae Infections - mortality</topic><topic>Paramyxoviridae Infections - 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Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goh, Khean Jin</au><au>Tan, Patrick Seow Koon</au><au>Tan, Chong Tin</au><au>Chew, Nee Kong</au><au>Kamarulzaman, Adeeba</au><au>Sarji, Sazilah Ahmad</au><au>Wong, Kum Thong</au><au>Abdullah, Basri Johan Jeet</au><au>Chua, Kaw Bing</au><au>Lam, Sai Kit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Features of Nipah Virus Encephalitis among Pig Farmers in Malaysia</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2000-04-27</date><risdate>2000</risdate><volume>342</volume><issue>17</issue><spage>1229</spage><epage>1235</epage><pages>1229-1235</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Between September 1998 and June 1999, there was an outbreak of febrile encephalitis in several pig-farming villages in Malaysia. More than 200 patients were admitted to hospitals nationwide, many of whom died.
1
–
3
The pig-farming industry was disrupted by the culling of many pigs to control the outbreak and the closing of farms. Several abattoir workers in neighboring Singapore were also affected.
4
,
5
Japanese encephalitis, a viral encephalitis associated with pigs that is endemic in Southeast Asia, was initially suspected, but clinical and epidemiologic features suggested that a different disease was responsible.
The isolation of a new paramyxovirus, subsequently named . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>10781618</pmid><doi>10.1056/NEJM200004273421701</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
subjects | Adult Animal Husbandry Animals Antibodies, Viral - blood Antibodies, Viral - cerebrospinal fluid Cerebrospinal Fluid - chemistry Cerebrospinal Fluid - immunology Disease Outbreaks - statistics & numerical data Electroencephalography Encephalitis Encephalitis, Viral - epidemiology Encephalitis, Viral - mortality Encephalitis, Viral - physiopathology Encephalitis, Viral - virology Female Hogs Humans Logistic Models Magnetic Resonance Imaging Malaysia Malaysia - epidemiology Male Nervous System Diseases - etiology Nipah virus NMR Nuclear magnetic resonance Paramyxoviridae Infections - complications Paramyxoviridae Infections - epidemiology Paramyxoviridae Infections - mortality Paramyxoviridae Infections - physiopathology Paramyxovirinae - immunology pigs Recurrence Swine |
title | Clinical Features of Nipah Virus Encephalitis among Pig Farmers in Malaysia |
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