Kinetic cooperativity of human liver alcohol dehydrogenase gamma(2)

Previous studies showed that natural human liver alcohol dehydrogenase gamma exhibits negative cooperativity (substrate activation) with ethanol. Studies with the recombinant gamma(2) isoenzyme now confirm that observation and show that the saturation kinetics with other alcohols are also nonhyperbo...

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Veröffentlicht in:	The Journal of biological chemistry 2000-04, Vol.275 (16), p.11569-11575
Hauptverfasser:	Charlier, Jr, H A, Plapp, B V
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Butanol - pharmacology Alcohol Dehydrogenase - metabolism Cyclohexanols - pharmacology Enzyme Activation Humans Kinetics Liver - enzymology Models, Chemical NAD - metabolism Recombinant Proteins - metabolism
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