Effect of ascorbic acid supplementation on the immune response of chickens vaccinated and challenged with infectious bursal disease virus
One-day-old chickens were divided into two groups and reared under similar conditions. One group was fed a diet supplemented with 1000 ppm ascorbic acid and the other group was fed an identical diet, but not supplemented with ascorbic acid. Both groups were vaccinated against infectious bursal disea...
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| Veröffentlicht in: | Veterinary immunology and immunopathology 2000-04, Vol.74 (1), p.145-152 |
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| creator | Wu, C.C. Dorairajan, T. Lin, T.L. |
| description | One-day-old chickens were divided into two groups and reared under similar conditions. One group was fed a diet supplemented with 1000
ppm ascorbic acid and the other group was fed an identical diet, but not supplemented with ascorbic acid. Both groups were vaccinated against infectious bursal disease (IBD) at 7 days of age and challenged orally with 4×10
5 of 50% embryo-lethal-dose IBDV 14 days later. The number of anti-IBDV antibody secreting cells, production of interleukin-2 (IL-2) by splenocytes, number of CD4
+, CD8
+ and IgM
+ cells in spleen and IgM
+ cells in bursa of Fabricius were compared between the two groups at 7 days (prior to vaccination), 21 days (14 days post-vaccination and prior to challenge) and 31 days (10 days post-challenge) of age. The number of CD8
+ in spleen at 7 days of age and IgM
+ cells in bursa at 7, 21 and 31 days of age were significantly higher in ascorbic acid supplemented group (
P |
| doi_str_mv | 10.1016/S0165-2427(00)00161-6 |
| format | Article |
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ppm ascorbic acid and the other group was fed an identical diet, but not supplemented with ascorbic acid. Both groups were vaccinated against infectious bursal disease (IBD) at 7 days of age and challenged orally with 4×10
5 of 50% embryo-lethal-dose IBDV 14 days later. The number of anti-IBDV antibody secreting cells, production of interleukin-2 (IL-2) by splenocytes, number of CD4
+, CD8
+ and IgM
+ cells in spleen and IgM
+ cells in bursa of Fabricius were compared between the two groups at 7 days (prior to vaccination), 21 days (14 days post-vaccination and prior to challenge) and 31 days (10 days post-challenge) of age. The number of CD8
+ in spleen at 7 days of age and IgM
+ cells in bursa at 7, 21 and 31 days of age were significantly higher in ascorbic acid supplemented group (
P<0.05). Production of IL-2 by splenocytes was higher as indicated by higher stimulation indices in ascorbic acid supplemented group. The number of anti-IBDV IgG antibody secreting cells in spleen at 21 and 31 days of age were significantly higher in ascorbic acid supplemented group (
P<0.05). Dietary supplementation of ascorbic acid may ameliorate the immunosuppression caused by IBDV vaccination and improve humoral and cellular immune responses.</description><identifier>ISSN: 0165-2427</identifier><identifier>EISSN: 1873-2534</identifier><identifier>DOI: 10.1016/S0165-2427(00)00161-6</identifier><identifier>PMID: 10760396</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>AIDS/HIV ; Animals ; Ascorbic acid ; Ascorbic Acid - administration & dosage ; Birnaviridae Infections - immunology ; Birnaviridae Infections - prevention & control ; Birnaviridae Infections - veterinary ; Bursa of Fabricius - immunology ; CD4-Positive T-Lymphocytes - chemistry ; CD8-Positive T-Lymphocytes - chemistry ; Cell Count ; Chick Embryo ; Chickens - immunology ; Culture Media, Conditioned ; Flow Cytometry - veterinary ; Immune response ; Immunoglobulin M - analysis ; Infectious bursal disease ; Infectious bursal disease virus ; Infectious bursal disease virus - immunology ; Interleukin-2 - analysis ; Poultry Diseases - immunology ; Poultry Diseases - prevention & control ; Random Allocation ; Scintillation Counting - veterinary ; Specific Pathogen-Free Organisms ; Spleen - immunology ; Vaccination ; Vaccination - veterinary ; Vitamin C</subject><ispartof>Veterinary immunology and immunopathology, 2000-04, Vol.74 (1), p.145-152</ispartof><rights>2000 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-b7fd99695a6ed8f849ec1ede3f150779ca62afa6ec27ae72ead2171c7e94a03c3</citedby><cites>FETCH-LOGICAL-c392t-b7fd99695a6ed8f849ec1ede3f150779ca62afa6ec27ae72ead2171c7e94a03c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165242700001616$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10760396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, C.C.</creatorcontrib><creatorcontrib>Dorairajan, T.</creatorcontrib><creatorcontrib>Lin, T.L.</creatorcontrib><title>Effect of ascorbic acid supplementation on the immune response of chickens vaccinated and challenged with infectious bursal disease virus</title><title>Veterinary immunology and immunopathology</title><addtitle>Vet Immunol Immunopathol</addtitle><description>One-day-old chickens were divided into two groups and reared under similar conditions. One group was fed a diet supplemented with 1000
ppm ascorbic acid and the other group was fed an identical diet, but not supplemented with ascorbic acid. Both groups were vaccinated against infectious bursal disease (IBD) at 7 days of age and challenged orally with 4×10
5 of 50% embryo-lethal-dose IBDV 14 days later. The number of anti-IBDV antibody secreting cells, production of interleukin-2 (IL-2) by splenocytes, number of CD4
+, CD8
+ and IgM
+ cells in spleen and IgM
+ cells in bursa of Fabricius were compared between the two groups at 7 days (prior to vaccination), 21 days (14 days post-vaccination and prior to challenge) and 31 days (10 days post-challenge) of age. The number of CD8
+ in spleen at 7 days of age and IgM
+ cells in bursa at 7, 21 and 31 days of age were significantly higher in ascorbic acid supplemented group (
P<0.05). Production of IL-2 by splenocytes was higher as indicated by higher stimulation indices in ascorbic acid supplemented group. The number of anti-IBDV IgG antibody secreting cells in spleen at 21 and 31 days of age were significantly higher in ascorbic acid supplemented group (
P<0.05). Dietary supplementation of ascorbic acid may ameliorate the immunosuppression caused by IBDV vaccination and improve humoral and cellular immune responses.</description><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Ascorbic acid</subject><subject>Ascorbic Acid - administration & dosage</subject><subject>Birnaviridae Infections - immunology</subject><subject>Birnaviridae Infections - prevention & control</subject><subject>Birnaviridae Infections - veterinary</subject><subject>Bursa of Fabricius - immunology</subject><subject>CD4-Positive T-Lymphocytes - chemistry</subject><subject>CD8-Positive T-Lymphocytes - chemistry</subject><subject>Cell Count</subject><subject>Chick Embryo</subject><subject>Chickens - immunology</subject><subject>Culture Media, Conditioned</subject><subject>Flow Cytometry - veterinary</subject><subject>Immune response</subject><subject>Immunoglobulin M - analysis</subject><subject>Infectious bursal disease</subject><subject>Infectious bursal disease virus</subject><subject>Infectious bursal disease virus - immunology</subject><subject>Interleukin-2 - analysis</subject><subject>Poultry Diseases - immunology</subject><subject>Poultry Diseases - prevention & control</subject><subject>Random Allocation</subject><subject>Scintillation Counting - veterinary</subject><subject>Specific Pathogen-Free Organisms</subject><subject>Spleen - immunology</subject><subject>Vaccination</subject><subject>Vaccination - veterinary</subject><subject>Vitamin C</subject><issn>0165-2427</issn><issn>1873-2534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2KFTEQhYMozp3RR1CyEl20Jv2TdFYiwzgKAy7UdahbqXij3ek26b7iI_jWpucO4m4gJFTynTqhDmPPpHgthVRvPpetq-q21i-FeCVKJSv1gO1kr5uq7pr2Idv9Q87Yec7fhRCd6fvH7EwKrURj1I79ufKecOGT55BxSvuAHDA4ntd5HmikuMASpsjLWg7EwziukXiiPE8x06bDQ8AfFDM_AmKIsJDjEF25h2Gg-K2Uv8Jy4CFuTmFaM9-vKcPAXcgEpckxpDU_YY88DJme3p0X7Ov7qy-XH6qbT9cfL9_dVNiYeqn22jtjlOlAket93xpCSY4aLzuhtUFQNfjyiLUG0jWBq6WWqMm0IBpsLtiLU985TT9XyosdQ0YaBohU_ma1FK1s2-5eUOquVkKoAnYnENOUcyJv5xRGSL-tFHYLy96GZbckrBD2Niy76Z7fGaz7kdx_qlM6BXh7AqjM4xgo2YyBIpILqYzSuincY_EX_u2ncg</recordid><startdate>20000419</startdate><enddate>20000419</enddate><creator>Wu, C.C.</creator><creator>Dorairajan, T.</creator><creator>Lin, T.L.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20000419</creationdate><title>Effect of ascorbic acid supplementation on the immune response of chickens vaccinated and challenged with infectious bursal disease virus</title><author>Wu, C.C. ; Dorairajan, T. ; Lin, T.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-b7fd99695a6ed8f849ec1ede3f150779ca62afa6ec27ae72ead2171c7e94a03c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Ascorbic acid</topic><topic>Ascorbic Acid - administration & dosage</topic><topic>Birnaviridae Infections - immunology</topic><topic>Birnaviridae Infections - prevention & control</topic><topic>Birnaviridae Infections - veterinary</topic><topic>Bursa of Fabricius - immunology</topic><topic>CD4-Positive T-Lymphocytes - chemistry</topic><topic>CD8-Positive T-Lymphocytes - chemistry</topic><topic>Cell Count</topic><topic>Chick Embryo</topic><topic>Chickens - immunology</topic><topic>Culture Media, Conditioned</topic><topic>Flow Cytometry - veterinary</topic><topic>Immune response</topic><topic>Immunoglobulin M - analysis</topic><topic>Infectious bursal disease</topic><topic>Infectious bursal disease virus</topic><topic>Infectious bursal disease virus - immunology</topic><topic>Interleukin-2 - analysis</topic><topic>Poultry Diseases - immunology</topic><topic>Poultry Diseases - prevention & control</topic><topic>Random Allocation</topic><topic>Scintillation Counting - veterinary</topic><topic>Specific Pathogen-Free Organisms</topic><topic>Spleen - immunology</topic><topic>Vaccination</topic><topic>Vaccination - veterinary</topic><topic>Vitamin C</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, C.C.</creatorcontrib><creatorcontrib>Dorairajan, T.</creatorcontrib><creatorcontrib>Lin, T.L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, C.C.</au><au>Dorairajan, T.</au><au>Lin, T.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of ascorbic acid supplementation on the immune response of chickens vaccinated and challenged with infectious bursal disease virus</atitle><jtitle>Veterinary immunology and immunopathology</jtitle><addtitle>Vet Immunol Immunopathol</addtitle><date>2000-04-19</date><risdate>2000</risdate><volume>74</volume><issue>1</issue><spage>145</spage><epage>152</epage><pages>145-152</pages><issn>0165-2427</issn><eissn>1873-2534</eissn><abstract>One-day-old chickens were divided into two groups and reared under similar conditions. One group was fed a diet supplemented with 1000
ppm ascorbic acid and the other group was fed an identical diet, but not supplemented with ascorbic acid. Both groups were vaccinated against infectious bursal disease (IBD) at 7 days of age and challenged orally with 4×10
5 of 50% embryo-lethal-dose IBDV 14 days later. The number of anti-IBDV antibody secreting cells, production of interleukin-2 (IL-2) by splenocytes, number of CD4
+, CD8
+ and IgM
+ cells in spleen and IgM
+ cells in bursa of Fabricius were compared between the two groups at 7 days (prior to vaccination), 21 days (14 days post-vaccination and prior to challenge) and 31 days (10 days post-challenge) of age. The number of CD8
+ in spleen at 7 days of age and IgM
+ cells in bursa at 7, 21 and 31 days of age were significantly higher in ascorbic acid supplemented group (
P<0.05). Production of IL-2 by splenocytes was higher as indicated by higher stimulation indices in ascorbic acid supplemented group. The number of anti-IBDV IgG antibody secreting cells in spleen at 21 and 31 days of age were significantly higher in ascorbic acid supplemented group (
P<0.05). Dietary supplementation of ascorbic acid may ameliorate the immunosuppression caused by IBDV vaccination and improve humoral and cellular immune responses.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>10760396</pmid><doi>10.1016/S0165-2427(00)00161-6</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Veterinary immunology and immunopathology, 2000-04, Vol.74 (1), p.145-152 |
| issn | 0165-2427 1873-2534 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71041445 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | AIDS/HIV Animals Ascorbic acid Ascorbic Acid - administration & dosage Birnaviridae Infections - immunology Birnaviridae Infections - prevention & control Birnaviridae Infections - veterinary Bursa of Fabricius - immunology CD4-Positive T-Lymphocytes - chemistry CD8-Positive T-Lymphocytes - chemistry Cell Count Chick Embryo Chickens - immunology Culture Media, Conditioned Flow Cytometry - veterinary Immune response Immunoglobulin M - analysis Infectious bursal disease Infectious bursal disease virus Infectious bursal disease virus - immunology Interleukin-2 - analysis Poultry Diseases - immunology Poultry Diseases - prevention & control Random Allocation Scintillation Counting - veterinary Specific Pathogen-Free Organisms Spleen - immunology Vaccination Vaccination - veterinary Vitamin C |
| title | Effect of ascorbic acid supplementation on the immune response of chickens vaccinated and challenged with infectious bursal disease virus |
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