Vibrio vulnificus septicemia in a patient with the hemochromatosis HFE C282Y mutation
Vibrio vulnificus is an extremely invasive gram-negative bacillus found in marine waters that causes overwhelming bacteremia and shock that is associated with high mortality. Impaired iron metabolism has been implicated in the susceptibility to V vulnificus bacterial infections. We report a case of...
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| Veröffentlicht in: | Archives of pathology & laboratory medicine (1976) 2001-08, Vol.125 (8), p.1107-1109 |
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| container_title | Archives of pathology & laboratory medicine (1976) |
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| creator | Gerhard, G S Levin, K A Price Goldstein, J Wojnar, M M Chorney, M J Belchis, D A |
| description | Vibrio vulnificus is an extremely invasive gram-negative bacillus found in marine waters that causes overwhelming bacteremia and shock that is associated with high mortality. Impaired iron metabolism has been implicated in the susceptibility to V vulnificus bacterial infections. We report a case of fatal V vulnificus sepsis in a 56-year-old man who died within 1 to 3 days after consuming raw seafood. At autopsy, he was found to have micronodular cirrhosis and iron overload. Postmortem genetic analysis revealed the presence of the hemochromatosis gene (HFE) C282Y mutation. To our knowledge, this is this first documented fatal case of V vulnificus infection in a patient proven to carry the HFE C282Y mutation. Because this patient was heterozygous for the major hereditary hemochromatosis mutation and was not previously diagnosed with clinical iron overload, the spectrum of clinical susceptibilities to V vulnificus infection may include carriers of the C282Y mutation. |
| doi_str_mv | 10.5858/2001-125-1107-VVSIAP |
| format | Article |
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Impaired iron metabolism has been implicated in the susceptibility to V vulnificus bacterial infections. We report a case of fatal V vulnificus sepsis in a 56-year-old man who died within 1 to 3 days after consuming raw seafood. At autopsy, he was found to have micronodular cirrhosis and iron overload. Postmortem genetic analysis revealed the presence of the hemochromatosis gene (HFE) C282Y mutation. To our knowledge, this is this first documented fatal case of V vulnificus infection in a patient proven to carry the HFE C282Y mutation. Because this patient was heterozygous for the major hereditary hemochromatosis mutation and was not previously diagnosed with clinical iron overload, the spectrum of clinical susceptibilities to V vulnificus infection may include carriers of the C282Y mutation.</description><identifier>ISSN: 0003-9985</identifier><identifier>ISSN: 1543-2165</identifier><identifier>EISSN: 1543-2165</identifier><identifier>DOI: 10.5858/2001-125-1107-VVSIAP</identifier><identifier>PMID: 11473471</identifier><identifier>CODEN: APLMAS</identifier><language>eng</language><publisher>United States: College of American Pathologists</publisher><subject>Animals ; Bacteremia - complications ; Bacteremia - diagnosis ; Causes of ; Complications and side effects ; Disseminated Intravascular Coagulation - microbiology ; Fatal Outcome ; Hemochromatosis ; Hemochromatosis - complications ; Hemochromatosis - genetics ; Hemochromatosis Protein ; Heterozygote ; Histocompatibility Antigens Class I - genetics ; HLA Antigens - genetics ; Humans ; Male ; Membrane Proteins ; Middle Aged ; Multiple Organ Failure - microbiology ; Mutation ; Ostreidae - microbiology ; Seafood - microbiology ; Seafood poisoning ; Septicemia ; Skin Diseases - microbiology ; Vibrio Infections - complications ; Vibrio Infections - diagnosis</subject><ispartof>Archives of pathology & laboratory medicine (1976), 2001-08, Vol.125 (8), p.1107-1109</ispartof><rights>COPYRIGHT 2001 College of American Pathologists</rights><rights>Copyright College of American Pathologists Aug 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-178503da90ad5e995c28b978afe69da63484e3bfdb75eef00ac426d0cb5790ae3</citedby><cites>FETCH-LOGICAL-c462t-178503da90ad5e995c28b978afe69da63484e3bfdb75eef00ac426d0cb5790ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11473471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gerhard, G S</creatorcontrib><creatorcontrib>Levin, K A</creatorcontrib><creatorcontrib>Price Goldstein, J</creatorcontrib><creatorcontrib>Wojnar, M M</creatorcontrib><creatorcontrib>Chorney, M J</creatorcontrib><creatorcontrib>Belchis, D A</creatorcontrib><title>Vibrio vulnificus septicemia in a patient with the hemochromatosis HFE C282Y mutation</title><title>Archives of pathology & laboratory medicine (1976)</title><addtitle>Arch Pathol Lab Med</addtitle><description>Vibrio vulnificus is an extremely invasive gram-negative bacillus found in marine waters that causes overwhelming bacteremia and shock that is associated with high mortality. Impaired iron metabolism has been implicated in the susceptibility to V vulnificus bacterial infections. We report a case of fatal V vulnificus sepsis in a 56-year-old man who died within 1 to 3 days after consuming raw seafood. At autopsy, he was found to have micronodular cirrhosis and iron overload. Postmortem genetic analysis revealed the presence of the hemochromatosis gene (HFE) C282Y mutation. To our knowledge, this is this first documented fatal case of V vulnificus infection in a patient proven to carry the HFE C282Y mutation. Because this patient was heterozygous for the major hereditary hemochromatosis mutation and was not previously diagnosed with clinical iron overload, the spectrum of clinical susceptibilities to V vulnificus infection may include carriers of the C282Y mutation.</description><subject>Animals</subject><subject>Bacteremia - complications</subject><subject>Bacteremia - diagnosis</subject><subject>Causes of</subject><subject>Complications and side effects</subject><subject>Disseminated Intravascular Coagulation - microbiology</subject><subject>Fatal Outcome</subject><subject>Hemochromatosis</subject><subject>Hemochromatosis - complications</subject><subject>Hemochromatosis - genetics</subject><subject>Hemochromatosis Protein</subject><subject>Heterozygote</subject><subject>Histocompatibility Antigens Class I - genetics</subject><subject>HLA Antigens - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Membrane Proteins</subject><subject>Middle Aged</subject><subject>Multiple Organ Failure - microbiology</subject><subject>Mutation</subject><subject>Ostreidae - microbiology</subject><subject>Seafood - microbiology</subject><subject>Seafood poisoning</subject><subject>Septicemia</subject><subject>Skin Diseases - microbiology</subject><subject>Vibrio Infections - complications</subject><subject>Vibrio Infections - diagnosis</subject><issn>0003-9985</issn><issn>1543-2165</issn><issn>1543-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptktFqFDEUhoNY7Fp9A5Eg6JWjSWYySS6XpbWFgoJ2wauQyZzppMxM1iRj6dubYRday5KLkPD9h8PPh9A7Sr5wyeVXRggtKOMFpUQU2-3Pq_WPF2hFeVUWjNb8JVoRQspCKclP0esY7_JTMUZfoVNKK1FWgq7QzdY1wXn8dx4m1zk7Rxxhl5yF0RnsJmzwziQHU8L3LvU49YB7GL3tgx9N8tFFfHlxjjdMst94nFOG_fQGnXRmiPD2cJ-hm4vzX5vL4vr7t6vN-rqwVc1SQYXkpGyNIqbloBS3TDZKSNNBrVpTl5WsoGy6thEcoCPE2IrVLbENFzkD5Rn6tJ-7C_7PDDHp0UULw2Am8HPUgpKKKEIz-OEZeOfnMOXdNKNUcamYfIRuzQDaTZ1Pwdhlol4LIQlXtMzQ5yPQLUwQzOAn6Fz-fooXR_B82lywPcZ_fML3YIbURz_MS6vxP67aczb4GAN0ehfcaMKDpkQvfujFD5390Isfeu9Hjr0_9DA3I7SPoYMQ5T-13rPd</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>Gerhard, G S</creator><creator>Levin, K A</creator><creator>Price Goldstein, J</creator><creator>Wojnar, M M</creator><creator>Chorney, M J</creator><creator>Belchis, D A</creator><general>College of American Pathologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20010801</creationdate><title>Vibrio vulnificus septicemia in a patient with the hemochromatosis HFE C282Y mutation</title><author>Gerhard, G S ; Levin, K A ; Price Goldstein, J ; Wojnar, M M ; Chorney, M J ; Belchis, D A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-178503da90ad5e995c28b978afe69da63484e3bfdb75eef00ac426d0cb5790ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Bacteremia - complications</topic><topic>Bacteremia - diagnosis</topic><topic>Causes of</topic><topic>Complications and side effects</topic><topic>Disseminated Intravascular Coagulation - microbiology</topic><topic>Fatal Outcome</topic><topic>Hemochromatosis</topic><topic>Hemochromatosis - complications</topic><topic>Hemochromatosis - genetics</topic><topic>Hemochromatosis Protein</topic><topic>Heterozygote</topic><topic>Histocompatibility Antigens Class I - genetics</topic><topic>HLA Antigens - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Membrane Proteins</topic><topic>Middle Aged</topic><topic>Multiple Organ Failure - microbiology</topic><topic>Mutation</topic><topic>Ostreidae - microbiology</topic><topic>Seafood - microbiology</topic><topic>Seafood poisoning</topic><topic>Septicemia</topic><topic>Skin Diseases - microbiology</topic><topic>Vibrio Infections - complications</topic><topic>Vibrio Infections - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gerhard, G S</creatorcontrib><creatorcontrib>Levin, K A</creatorcontrib><creatorcontrib>Price Goldstein, J</creatorcontrib><creatorcontrib>Wojnar, M M</creatorcontrib><creatorcontrib>Chorney, M J</creatorcontrib><creatorcontrib>Belchis, D A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of pathology & laboratory medicine (1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gerhard, G S</au><au>Levin, K A</au><au>Price Goldstein, J</au><au>Wojnar, M M</au><au>Chorney, M J</au><au>Belchis, D A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vibrio vulnificus septicemia in a patient with the hemochromatosis HFE C282Y mutation</atitle><jtitle>Archives of pathology & laboratory medicine (1976)</jtitle><addtitle>Arch Pathol Lab Med</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>125</volume><issue>8</issue><spage>1107</spage><epage>1109</epage><pages>1107-1109</pages><issn>0003-9985</issn><issn>1543-2165</issn><eissn>1543-2165</eissn><coden>APLMAS</coden><abstract>Vibrio vulnificus is an extremely invasive gram-negative bacillus found in marine waters that causes overwhelming bacteremia and shock that is associated with high mortality. Impaired iron metabolism has been implicated in the susceptibility to V vulnificus bacterial infections. We report a case of fatal V vulnificus sepsis in a 56-year-old man who died within 1 to 3 days after consuming raw seafood. At autopsy, he was found to have micronodular cirrhosis and iron overload. Postmortem genetic analysis revealed the presence of the hemochromatosis gene (HFE) C282Y mutation. To our knowledge, this is this first documented fatal case of V vulnificus infection in a patient proven to carry the HFE C282Y mutation. Because this patient was heterozygous for the major hereditary hemochromatosis mutation and was not previously diagnosed with clinical iron overload, the spectrum of clinical susceptibilities to V vulnificus infection may include carriers of the C282Y mutation.</abstract><cop>United States</cop><pub>College of American Pathologists</pub><pmid>11473471</pmid><doi>10.5858/2001-125-1107-VVSIAP</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Allen Press Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Bacteremia - complications Bacteremia - diagnosis Causes of Complications and side effects Disseminated Intravascular Coagulation - microbiology Fatal Outcome Hemochromatosis Hemochromatosis - complications Hemochromatosis - genetics Hemochromatosis Protein Heterozygote Histocompatibility Antigens Class I - genetics HLA Antigens - genetics Humans Male Membrane Proteins Middle Aged Multiple Organ Failure - microbiology Mutation Ostreidae - microbiology Seafood - microbiology Seafood poisoning Septicemia Skin Diseases - microbiology Vibrio Infections - complications Vibrio Infections - diagnosis |
| title | Vibrio vulnificus septicemia in a patient with the hemochromatosis HFE C282Y mutation |
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