Effect of cyclooxygenase and nitric oxide synthase inhibitors on tumor growth in mouse tumor models with and without cancer cachexia related to prostanoids

The potential interaction between cyclooxygenase (Cox) and NO metabolic pathways in the control of local tumor growth was evaluated. Mice bearing either a sarcoma-derived tumor (C57B1; MCG 101) or a malignant melanoma (C3H/HeN; K1735-M2) were used. These models were principally different because the...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-03, Vol.60 (6), p.1742-1749
Hauptverfasser:	CAHLIN, C, GELIN, J, DELBRO, D, LÖNNROTH, C, DOI, C, LUNDHOLM, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cachexia - blood Cachexia - etiology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Dinoprostone - blood Disease Models, Animal Enzyme Inhibitors - pharmacology Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Growth Substances - genetics Immunohistochemistry Indans - pharmacology Indomethacin - pharmacology Iodine Radioisotopes Mice Mice, Inbred C3H Mice, Inbred C57BL Molecular and cellular biology Neoplasms, Experimental - complications Neoplasms, Experimental - enzymology Neoplasms, Experimental - pathology NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Nitroarginine - pharmacology Prostaglandin-Endoperoxide Synthases - drug effects Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - metabolism Prostaglandins - blood RNA, Messenger - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Tumor Cells, Cultured
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