Sodium‐calcium exchanger (NCX‐1) and calcium modulation: NCX protein expression patterns and regulation of early heart development

Ouabain‐induced inhibition of early heart development indicated that Na/K‐ATPase plays an important role in maintaining normal ionic balances during differentiation of cardiomyocytes (Linask and Gui [1995] Dev Dyn 203:93–105). Inhibition of the sodium pump is generally accepted to affect the activit...

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Veröffentlicht in:	Developmental dynamics 2001-07, Vol.221 (3), p.249-264
Hauptverfasser:	Linask, Kersti K., Han, Ming‐Da, Artman, Michael, Ludwig, Cheryl A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals asymmetry calcium Calcium - metabolism cardiac contractility Chick Embryo Embryonic and Fetal Development Enzyme Inhibitors - pharmacology Gene Expression Profiling Heart - drug effects Heart - embryology Heart - physiology heart development Ionomycin - pharmacology Ionophores - pharmacology KB‐R7943 inhibitor Mice Mice, Inbred C57BL Myocardial Contraction Myocardium - metabolism NaCa exchanger NCX‐1 Ouabain - pharmacology RNA, Messenger Sodium-Calcium Exchanger - biosynthesis Sodium-Calcium Exchanger - genetics Sodium-Calcium Exchanger - physiology Thiourea - analogs & derivatives Thiourea - pharmacology
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