The loss of mdm2 induces p53 mediated apoptosis

The p53 tumor suppressor gene product is negatively regulated by the product of its downstream target, mdm2. The deletion of mdm2 in the mouse results in embryonic lethality at 5.5 days post coitum (d.p.c.) which can be overcome by simultaneous loss of the p53 tumor suppressor, substantiating the im...

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Veröffentlicht in:	Oncogene 2000-03, Vol.19 (13), p.1691-1697
Hauptverfasser:	DE ROZIERES, S, MAYA, R, OREN, M, LOZANO, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - genetics Apoptosis - physiology Biological and medical sciences Cancer Cell cycle Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells, Cultured Embryo fibroblasts Embryo, Mammalian Embryos Fibroblasts Fibroblasts - cytology Fundamental and applied biological sciences. Psychology G1 Phase Gene Expression Regulation Genes, Lethal Genes, p53 Genes, Synthetic Genetic Vectors - genetics Genotype & phenotype Humans Infections Kinases Lethality mdm2 gene MDM2 protein Mice Mice, Knockout Molecular and cellular biology Mutation Nuclear Proteins p53 Protein Phenotype Phenotypes Proto-Oncogene Proteins - deficiency Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-mdm2 Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - physiology Stem cells Temperature Transfection Tumor suppressor genes Tumor Suppressor Protein p53 - deficiency Tumor Suppressor Protein p53 - physiology Tumorigenesis Tumors
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