Lysophosphatidylcholine Inhibits Endothelial Cell Migration and Proliferation via Inhibition of the Extracellular Signal–Regulated Kinase Pathway

ABSTRACTLysophosphatidylcholine (lysoPC), a major lipid component of oxidized low density lipoprotein, inhibits endothelial cell (EC) migration and proliferation, which are critical processes during angiogenesis and the repair of injured vessels. However, the mechanism(s) of lysoPC-induced inhibitio...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2000-04, Vol.20 (4), p.1006-1012
Hauptverfasser:	Rikitake, Yoshiyuki, Kawashima, Seinosuke, Yamashita, Tomoya, Ueyama, Tomomi, Ishido, Satoshi, Hotta, Hak, Hirata, Ken-ichi, Yokoyama, Mitsuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cattle Cell Division - drug effects Cell Movement - drug effects Cells, Cultured Diseases of the aorta Endothelium, Vascular - cytology Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Fibroblast Growth Factor 2 - pharmacology Flavonoids - pharmacology Gene Expression Lysophosphatidylcholines - pharmacology MAP Kinase Kinase 1 Medical sciences Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Mutation Phosphotyrosine - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism ras Proteins - metabolism Signal Transduction Type C Phospholipases - metabolism
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