Synthesis of the C16−C28 Spiroketal Subunit of Spongistatin 1 (Altohyrtin A):  The Pyrone Approach

The synthesis of the CD spiroketal fragment of spongistatin 1 (altohyrtin A) has been accomplished utilizing the addition of a metalated pyrone to an aldehyde and subsequent acid-catalyzed spirocyclization. A stereoselective hydrogenation and subsequent conformational inversion establish the C19 ste...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Organic letters 2000-04, Vol.2 (7), p.957-960
Hauptverfasser:	Crimmins, Michael T, Katz, Jason D
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - chemistry Antineoplastic Agents - chemical synthesis Cyclization Ethers, Cyclic - chemical synthesis Lactones - chemical synthesis Macrolides Molecular Conformation Pyrones - chemistry Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!