Biological effects induced by variable levels of BCR-ABL protein in the pluripotent hematopoietic cell line UT-7

There is currently no satisfactory model allowing analysis of dose-effect relationships of BCR-ABL proteins in human hematopoietic cells. To study comparatively the proliferative, differentiative and anti-apoptotic actions of different levels of BCR-ABL proteins in the context of the same cellular b...

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Veröffentlicht in:	Leukemia 2000-04, Vol.14 (4), p.662-670
Hauptverfasser:	ISSAAD, C, AHMED, M, NOVAULT, S, BONNET, M. L, BENNARDO, T, VARET, B, VAINCHENKER, W, TURHAN, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Abl gene Animals Apoptosis BCR gene BCR-ABL protein Biological and medical sciences Biological effects Care and treatment Cell culture Cell differentiation Cell Division Cell Survival Chronic myeloid leukemia Clone Cells Cloning Control Deprivation Dose-response relationship (Biochemistry) Fusion protein Fusion Proteins, bcr-abl - biosynthesis Fusion Proteins, bcr-abl - genetics Fusion Proteins, bcr-abl - physiology Gene Expression Regulation, Leukemic Genetic aspects Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Growth factors Health aspects Hematologic and hematopoietic diseases Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Humans Leukemia - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Mice Mice, Nude Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Phenotypes Pluripotency Proteins Recombinant Fusion Proteins - physiology Stimuli Transfection Tumor Cells, Cultured Tumor proteins Tumors Western blotting
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