Pineal indoles stimulate the gene expression of immunomodulating cytokines
Male C57 mice received 10 consecutive daily intraperitoneal injections of melatonin, 5-methoxytryptamine or 5-methoxytryptophol (5mg/kg body weight). Control mice received the alcoholic saline vehicle. All mice were sacrificed 24 hours after the last injection. Following extraction of RNA from perit...
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| Veröffentlicht in: | Journal of Neural Transmission 2001-01, Vol.108 (4), p.397-405 |
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| description | Male C57 mice received 10 consecutive daily intraperitoneal injections of melatonin, 5-methoxytryptamine or 5-methoxytryptophol (5mg/kg body weight). Control mice received the alcoholic saline vehicle. All mice were sacrificed 24 hours after the last injection. Following extraction of RNA from peritoneal exudate cells (PEC) and splenocytes, the level of gene expression was analyzed with the reverse transcription-polymerase chain reaction (RT-PCR). The results revealed that melatonin up-regulated the level of gene expression of transforming growth factor-beta (TGF-beta), macrophage-colony stimulating factor (M-CSF), tumor necrosis factor-alpha (TNF-alpha) and stem cell factor (SCF) in PEC, and the level of gene expression of interleukin-1beta (IL-1beta), M-CSF, TNF-alpha, interferon-gamma (IFN-gamma) and SCF in splenocytes. 5-Methoxytryptamine augmented the level of gene expression of TGF-beta, M-CSF and SCF in PEC, and the level of gene expression of IL-1beta, TNF-alpha, IFN-gamma, M-CSF and SCF in splenocytes. 5-Methoxytryptophol elevated the level of gene expression of TNF-alpha, IL-1beta, TGF-beta and M-CSF in PEC, and the level of gene expression of inducible nitric oxide synthase (iNOS), IL-1beta, M-CSF, TNF-alpha, IFN-gamma and SCF in splenocytes. |
| doi_str_mv | 10.1007/s007020170061 |
| format | Article |
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B ; FUNG, M. C</creator><creatorcontrib>LIU, F ; NG, T. B ; FUNG, M. C</creatorcontrib><description>Male C57 mice received 10 consecutive daily intraperitoneal injections of melatonin, 5-methoxytryptamine or 5-methoxytryptophol (5mg/kg body weight). Control mice received the alcoholic saline vehicle. All mice were sacrificed 24 hours after the last injection. Following extraction of RNA from peritoneal exudate cells (PEC) and splenocytes, the level of gene expression was analyzed with the reverse transcription-polymerase chain reaction (RT-PCR). The results revealed that melatonin up-regulated the level of gene expression of transforming growth factor-beta (TGF-beta), macrophage-colony stimulating factor (M-CSF), tumor necrosis factor-alpha (TNF-alpha) and stem cell factor (SCF) in PEC, and the level of gene expression of interleukin-1beta (IL-1beta), M-CSF, TNF-alpha, interferon-gamma (IFN-gamma) and SCF in splenocytes. 5-Methoxytryptamine augmented the level of gene expression of TGF-beta, M-CSF and SCF in PEC, and the level of gene expression of IL-1beta, TNF-alpha, IFN-gamma, M-CSF and SCF in splenocytes. 5-Methoxytryptophol elevated the level of gene expression of TNF-alpha, IL-1beta, TGF-beta and M-CSF in PEC, and the level of gene expression of inducible nitric oxide synthase (iNOS), IL-1beta, M-CSF, TNF-alpha, IFN-gamma and SCF in splenocytes.</description><identifier>ISSN: 0300-9564</identifier><identifier>EISSN: 1435-1463</identifier><identifier>DOI: 10.1007/s007020170061</identifier><identifier>PMID: 11475007</identifier><identifier>CODEN: JNTMAH</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>5-Methoxytryptamine ; 5-Methoxytryptamine - pharmacology ; 5-Methoxytryptophol ; Adjuvants, Immunologic - pharmacology ; Animals ; Anti-Anxiety Agents - pharmacology ; Biological and medical sciences ; Cytokines - genetics ; DNA Primers ; Exudates and Transudates - cytology ; Fundamental and applied biological sciences. Psychology ; Gene Expression - drug effects ; Gene Expression - immunology ; Hormones and neuropeptides. Regulation ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; indole ; Indoles - pharmacology ; Injections, Intraperitoneal ; Interferon-gamma - genetics ; Interleukin-1 - genetics ; Macrophage Colony-Stimulating Factor - genetics ; Male ; Melatonin - pharmacology ; Mice ; Mice, Inbred C57BL ; Peritoneum - cytology ; Pineal Gland - physiology ; Spleen - cytology ; Stem Cell Factor - genetics ; Transforming Growth Factor beta - genetics ; Tumor Necrosis Factor-alpha - genetics ; Vertebrates: endocrinology</subject><ispartof>Journal of Neural Transmission, 2001-01, Vol.108 (4), p.397-405</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-b765146dad2ab7eb9d1ba8ee18bca792101bdb8aaf036aeedd4cf87e169f08223</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=917565$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11475007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LIU, F</creatorcontrib><creatorcontrib>NG, T. B</creatorcontrib><creatorcontrib>FUNG, M. C</creatorcontrib><title>Pineal indoles stimulate the gene expression of immunomodulating cytokines</title><title>Journal of Neural Transmission</title><addtitle>J Neural Transm (Vienna)</addtitle><description>Male C57 mice received 10 consecutive daily intraperitoneal injections of melatonin, 5-methoxytryptamine or 5-methoxytryptophol (5mg/kg body weight). Control mice received the alcoholic saline vehicle. All mice were sacrificed 24 hours after the last injection. Following extraction of RNA from peritoneal exudate cells (PEC) and splenocytes, the level of gene expression was analyzed with the reverse transcription-polymerase chain reaction (RT-PCR). The results revealed that melatonin up-regulated the level of gene expression of transforming growth factor-beta (TGF-beta), macrophage-colony stimulating factor (M-CSF), tumor necrosis factor-alpha (TNF-alpha) and stem cell factor (SCF) in PEC, and the level of gene expression of interleukin-1beta (IL-1beta), M-CSF, TNF-alpha, interferon-gamma (IFN-gamma) and SCF in splenocytes. 5-Methoxytryptamine augmented the level of gene expression of TGF-beta, M-CSF and SCF in PEC, and the level of gene expression of IL-1beta, TNF-alpha, IFN-gamma, M-CSF and SCF in splenocytes. 5-Methoxytryptophol elevated the level of gene expression of TNF-alpha, IL-1beta, TGF-beta and M-CSF in PEC, and the level of gene expression of inducible nitric oxide synthase (iNOS), IL-1beta, M-CSF, TNF-alpha, IFN-gamma and SCF in splenocytes.</description><subject>5-Methoxytryptamine</subject><subject>5-Methoxytryptamine - pharmacology</subject><subject>5-Methoxytryptophol</subject><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Animals</subject><subject>Anti-Anxiety Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cytokines - genetics</subject><subject>DNA Primers</subject><subject>Exudates and Transudates - cytology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression - drug effects</subject><subject>Gene Expression - immunology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>indole</subject><subject>Indoles - pharmacology</subject><subject>Injections, Intraperitoneal</subject><subject>Interferon-gamma - genetics</subject><subject>Interleukin-1 - genetics</subject><subject>Macrophage Colony-Stimulating Factor - genetics</subject><subject>Male</subject><subject>Melatonin - pharmacology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Peritoneum - cytology</subject><subject>Pineal Gland - physiology</subject><subject>Spleen - cytology</subject><subject>Stem Cell Factor - genetics</subject><subject>Transforming Growth Factor beta - genetics</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Vertebrates: endocrinology</subject><issn>0300-9564</issn><issn>1435-1463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1LxDAQBuAgiruuHr1KQfBWnWnaJD3K4icLetBzSZvpGm2btWnB_fdm2UXx5GXm8szL8DJ2inCJAPLKhwEJoAQQuMemmPIsxlTwfTYFDhDnmUgn7Mj7dwBAlOqQTRBTmYXDKXt8th3pJrKdcQ35yA-2HRs9UDS8UbSkjiL6WvXkvXVd5OrItu3YudaZjbLdMqrWg_sIIf6YHdS68XSy2zP2envzMr-PF093D_PrRVzxVA1xKUUW_jPaJLqUVOYGS62IUJWVlnmCgKUpldY1cKGJjEmrWklCkdegkoTP2MU2d9W7z5H8ULTWV9Q0uiM3-kJiOIQU_4WoUEAueYDxFla9876nulj1ttX9ukAoNi0Xf1oO_mwXPJYtmV-9qzWA8x3QvtJN3euusv7H5SgzkfFvtauFHw</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>LIU, F</creator><creator>NG, T. B</creator><creator>FUNG, M. C</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20010101</creationdate><title>Pineal indoles stimulate the gene expression of immunomodulating cytokines</title><author>LIU, F ; NG, T. B ; FUNG, M. C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-b765146dad2ab7eb9d1ba8ee18bca792101bdb8aaf036aeedd4cf87e169f08223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>5-Methoxytryptamine</topic><topic>5-Methoxytryptamine - pharmacology</topic><topic>5-Methoxytryptophol</topic><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Animals</topic><topic>Anti-Anxiety Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cytokines - genetics</topic><topic>DNA Primers</topic><topic>Exudates and Transudates - cytology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression - drug effects</topic><topic>Gene Expression - immunology</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>indole</topic><topic>Indoles - pharmacology</topic><topic>Injections, Intraperitoneal</topic><topic>Interferon-gamma - genetics</topic><topic>Interleukin-1 - genetics</topic><topic>Macrophage Colony-Stimulating Factor - genetics</topic><topic>Male</topic><topic>Melatonin - pharmacology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Peritoneum - cytology</topic><topic>Pineal Gland - physiology</topic><topic>Spleen - cytology</topic><topic>Stem Cell Factor - genetics</topic><topic>Transforming Growth Factor beta - genetics</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LIU, F</creatorcontrib><creatorcontrib>NG, T. B</creatorcontrib><creatorcontrib>FUNG, M. C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Neural Transmission</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LIU, F</au><au>NG, T. B</au><au>FUNG, M. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pineal indoles stimulate the gene expression of immunomodulating cytokines</atitle><jtitle>Journal of Neural Transmission</jtitle><addtitle>J Neural Transm (Vienna)</addtitle><date>2001-01-01</date><risdate>2001</risdate><volume>108</volume><issue>4</issue><spage>397</spage><epage>405</epage><pages>397-405</pages><issn>0300-9564</issn><eissn>1435-1463</eissn><coden>JNTMAH</coden><abstract>Male C57 mice received 10 consecutive daily intraperitoneal injections of melatonin, 5-methoxytryptamine or 5-methoxytryptophol (5mg/kg body weight). Control mice received the alcoholic saline vehicle. All mice were sacrificed 24 hours after the last injection. Following extraction of RNA from peritoneal exudate cells (PEC) and splenocytes, the level of gene expression was analyzed with the reverse transcription-polymerase chain reaction (RT-PCR). The results revealed that melatonin up-regulated the level of gene expression of transforming growth factor-beta (TGF-beta), macrophage-colony stimulating factor (M-CSF), tumor necrosis factor-alpha (TNF-alpha) and stem cell factor (SCF) in PEC, and the level of gene expression of interleukin-1beta (IL-1beta), M-CSF, TNF-alpha, interferon-gamma (IFN-gamma) and SCF in splenocytes. 5-Methoxytryptamine augmented the level of gene expression of TGF-beta, M-CSF and SCF in PEC, and the level of gene expression of IL-1beta, TNF-alpha, IFN-gamma, M-CSF and SCF in splenocytes. 5-Methoxytryptophol elevated the level of gene expression of TNF-alpha, IL-1beta, TGF-beta and M-CSF in PEC, and the level of gene expression of inducible nitric oxide synthase (iNOS), IL-1beta, M-CSF, TNF-alpha, IFN-gamma and SCF in splenocytes.</abstract><cop>Wien</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>11475007</pmid><doi>10.1007/s007020170061</doi><tpages>9</tpages></addata></record> |
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| subjects | 5-Methoxytryptamine 5-Methoxytryptamine - pharmacology 5-Methoxytryptophol Adjuvants, Immunologic - pharmacology Animals Anti-Anxiety Agents - pharmacology Biological and medical sciences Cytokines - genetics DNA Primers Exudates and Transudates - cytology Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Gene Expression - immunology Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis indole Indoles - pharmacology Injections, Intraperitoneal Interferon-gamma - genetics Interleukin-1 - genetics Macrophage Colony-Stimulating Factor - genetics Male Melatonin - pharmacology Mice Mice, Inbred C57BL Peritoneum - cytology Pineal Gland - physiology Spleen - cytology Stem Cell Factor - genetics Transforming Growth Factor beta - genetics Tumor Necrosis Factor-alpha - genetics Vertebrates: endocrinology |
| title | Pineal indoles stimulate the gene expression of immunomodulating cytokines |
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