Haemodynamic response following a 10% topload infusion of HemolinkTM in conscious, anaesthetized and treated spontaneously hypertensive rats

HemolinkTM (HLK), a haemoglobin‐based oxygen carrier (HBOC), is currently undergoing Phase II/III clinical trials in surgical patients. It causes some blood pressure rise in animal and human tests. This study was designed to investigate the systemic haemodynamic response to HemolinkTM in spontaneous...

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Veröffentlicht in:	Transfusion medicine (Oxford, England) England), 2000-03, Vol.10 (1), p.13-22
Hauptverfasser:	Ning, J, Wong, L T, Christoff, B, Carmichael, F J, Biro, G P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antihypertensive agents Blood Pressure - drug effects blood substitute Blood Substitutes - administration & dosage Blood Substitutes - adverse effects Blood Transfusion Hemoglobins - administration & dosage Hemoglobins - adverse effects Humans Hypertension - drug therapy Hypertension - physiopathology Infusions, Intravenous Nifedipine - pharmacology Nifedipine - therapeutic use polymerized haemoglobin Raffinose - administration & dosage Raffinose - adverse effects Raffinose - analogs & derivatives Rats Rats, Inbred SHR Rats, Inbred WKY vasoconstriction Vasodilator Agents - pharmacology Vasodilator Agents - therapeutic use
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