Pathological effects of extensive radiofrequency energy applications in the pulmonary veins in dogs
The long-term complications of catheter ablation within the pulmonary veins are unknown. The development of pulmonary vein stenosis has recently been described after catheter ablation to treat either chronic or paroxysmal atrial fibrillation. The purpose of this study was to examine the pathological...
Gespeichert in:
| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2000-04, Vol.101 (14), p.1736-1742 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1742 |
|---|---|
| container_issue | 14 |
| container_start_page | 1736 |
| container_title | Circulation (New York, N.Y.) |
| container_volume | 101 |
| creator | TAYLOR, G. W KAY, G. N XIANGSHENG ZHENG BISHOP, S IDEKER, R. E |
| description | The long-term complications of catheter ablation within the pulmonary veins are unknown. The development of pulmonary vein stenosis has recently been described after catheter ablation to treat either chronic or paroxysmal atrial fibrillation. The purpose of this study was to examine the pathological and hemodynamic effects of radiofrequency (RF) energy application within the pulmonary veins.
Right heart and transseptal catheterization were performed in 9 anesthetized mongrel dogs. The pulmonary vein ostia were cannulated and pulmonary venous pressure was measured before RF energy application in up to 4 separate pulmonary veins. Animals were euthanized at intervals of 2 to 4 weeks (n=3), 6 to 8 weeks (n=3), or 10 to 14 weeks (n=3) after ablation. Repeat catheterization before euthanasia demonstrated statistically significant differences in pulmonary capillary wedge pressure, cardiac output, pulmonary vascular resistance, and systemic vascular resistance (P |
| doi_str_mv | 10.1161/01.cir.101.14.1736 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71034232</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71034232</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-cc347da7ee6d9c8e26f8c89fe4f4fb91a03e3c13ba2366c64ee9d28c6ead30963</originalsourceid><addsrcrecordid>eNpdkFFrFDEUhYModtv6B3yQIOLbrLlJJsk8ylJtoVAR-xyymZttyuxkTGZK99-bsguKT4d7-c7l3EPIe2BrAAVfGKx9zGuoCnINWqhXZAUtl41sRfearBhjXaMF52fkvJTHOiqh27fkDJhuDWvNivgfbn5IQ9pF7waKIaCfC02B4vOMY4lPSLPrYwoZfy84-gPFEfPuQN00DdUzxzQWGkc6PyCdlmGfRpcP9Anjcd2nXbkkb4IbCr476QW5_3b1a3Pd3N59v9l8vW18y8zceC-k7p1GVH3nDXIVjDddQBlk2HbgmEDhQWwdF0p5JRG7nhuv0PWCdUpckM_Hu1NONWyZ7T4Wj8PgRkxLsRqYkFzwCn78D3xMSx5rNsuBK90yrSvEj5DPqZSMwU457utzFph96d8ysJubn3UEC9K-9F9NH06Xl-0e-38sx8Ir8OkEuFIbD9mNPpa_nOBgjBR_ALbXj7g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>212675077</pqid></control><display><type>article</type><title>Pathological effects of extensive radiofrequency energy applications in the pulmonary veins in dogs</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><creator>TAYLOR, G. W ; KAY, G. N ; XIANGSHENG ZHENG ; BISHOP, S ; IDEKER, R. E</creator><creatorcontrib>TAYLOR, G. W ; KAY, G. N ; XIANGSHENG ZHENG ; BISHOP, S ; IDEKER, R. E</creatorcontrib><description>The long-term complications of catheter ablation within the pulmonary veins are unknown. The development of pulmonary vein stenosis has recently been described after catheter ablation to treat either chronic or paroxysmal atrial fibrillation. The purpose of this study was to examine the pathological and hemodynamic effects of radiofrequency (RF) energy application within the pulmonary veins.
Right heart and transseptal catheterization were performed in 9 anesthetized mongrel dogs. The pulmonary vein ostia were cannulated and pulmonary venous pressure was measured before RF energy application in up to 4 separate pulmonary veins. Animals were euthanized at intervals of 2 to 4 weeks (n=3), 6 to 8 weeks (n=3), or 10 to 14 weeks (n=3) after ablation. Repeat catheterization before euthanasia demonstrated statistically significant differences in pulmonary capillary wedge pressure, cardiac output, pulmonary vascular resistance, and systemic vascular resistance (P<0.05) compared with the baseline. Luminal narrowing was observed in 22 of 33 pulmonary veins to which RF energy was applied. Of these, 7 were totally occluded, 7 had severe stenosis, and 8 were only minimally narrowed. Histological examination revealed intimal proliferation with organizing thrombus, necrotic myocardium in various stages of collagen replacement, endovascular contraction, and a proliferation of elastic lamina.
Applications of RF current within the pulmonary veins may result in pulmonary vein narrowing or complete occlusion. These observations should be considered in treatment of arrhythmias originating within the pulmonary veins.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.cir.101.14.1736</identifier><identifier>PMID: 10758058</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Biological and medical sciences ; Catheter Ablation - adverse effects ; Constriction, Pathologic ; Diseases of the cardiovascular system ; Dogs ; Female ; Hemodynamics ; Male ; Medical sciences ; Pulmonary Veins - pathology ; Pulmonary Veins - physiopathology ; Pulmonary Veins - radiation effects ; Pulmonary Veins - surgery ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Tunica Intima - pathology ; Tunica Intima - radiation effects</subject><ispartof>Circulation (New York, N.Y.), 2000-04, Vol.101 (14), p.1736-1742</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Apr 11, 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-cc347da7ee6d9c8e26f8c89fe4f4fb91a03e3c13ba2366c64ee9d28c6ead30963</citedby><cites>FETCH-LOGICAL-c508t-cc347da7ee6d9c8e26f8c89fe4f4fb91a03e3c13ba2366c64ee9d28c6ead30963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1321884$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10758058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TAYLOR, G. W</creatorcontrib><creatorcontrib>KAY, G. N</creatorcontrib><creatorcontrib>XIANGSHENG ZHENG</creatorcontrib><creatorcontrib>BISHOP, S</creatorcontrib><creatorcontrib>IDEKER, R. E</creatorcontrib><title>Pathological effects of extensive radiofrequency energy applications in the pulmonary veins in dogs</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>The long-term complications of catheter ablation within the pulmonary veins are unknown. The development of pulmonary vein stenosis has recently been described after catheter ablation to treat either chronic or paroxysmal atrial fibrillation. The purpose of this study was to examine the pathological and hemodynamic effects of radiofrequency (RF) energy application within the pulmonary veins.
Right heart and transseptal catheterization were performed in 9 anesthetized mongrel dogs. The pulmonary vein ostia were cannulated and pulmonary venous pressure was measured before RF energy application in up to 4 separate pulmonary veins. Animals were euthanized at intervals of 2 to 4 weeks (n=3), 6 to 8 weeks (n=3), or 10 to 14 weeks (n=3) after ablation. Repeat catheterization before euthanasia demonstrated statistically significant differences in pulmonary capillary wedge pressure, cardiac output, pulmonary vascular resistance, and systemic vascular resistance (P<0.05) compared with the baseline. Luminal narrowing was observed in 22 of 33 pulmonary veins to which RF energy was applied. Of these, 7 were totally occluded, 7 had severe stenosis, and 8 were only minimally narrowed. Histological examination revealed intimal proliferation with organizing thrombus, necrotic myocardium in various stages of collagen replacement, endovascular contraction, and a proliferation of elastic lamina.
Applications of RF current within the pulmonary veins may result in pulmonary vein narrowing or complete occlusion. These observations should be considered in treatment of arrhythmias originating within the pulmonary veins.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Catheter Ablation - adverse effects</subject><subject>Constriction, Pathologic</subject><subject>Diseases of the cardiovascular system</subject><subject>Dogs</subject><subject>Female</subject><subject>Hemodynamics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pulmonary Veins - pathology</subject><subject>Pulmonary Veins - physiopathology</subject><subject>Pulmonary Veins - radiation effects</subject><subject>Pulmonary Veins - surgery</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Tunica Intima - pathology</subject><subject>Tunica Intima - radiation effects</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkFFrFDEUhYModtv6B3yQIOLbrLlJJsk8ylJtoVAR-xyymZttyuxkTGZK99-bsguKT4d7-c7l3EPIe2BrAAVfGKx9zGuoCnINWqhXZAUtl41sRfearBhjXaMF52fkvJTHOiqh27fkDJhuDWvNivgfbn5IQ9pF7waKIaCfC02B4vOMY4lPSLPrYwoZfy84-gPFEfPuQN00DdUzxzQWGkc6PyCdlmGfRpcP9Anjcd2nXbkkb4IbCr476QW5_3b1a3Pd3N59v9l8vW18y8zceC-k7p1GVH3nDXIVjDddQBlk2HbgmEDhQWwdF0p5JRG7nhuv0PWCdUpckM_Hu1NONWyZ7T4Wj8PgRkxLsRqYkFzwCn78D3xMSx5rNsuBK90yrSvEj5DPqZSMwU457utzFph96d8ysJubn3UEC9K-9F9NH06Xl-0e-38sx8Ir8OkEuFIbD9mNPpa_nOBgjBR_ALbXj7g</recordid><startdate>20000411</startdate><enddate>20000411</enddate><creator>TAYLOR, G. W</creator><creator>KAY, G. N</creator><creator>XIANGSHENG ZHENG</creator><creator>BISHOP, S</creator><creator>IDEKER, R. E</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20000411</creationdate><title>Pathological effects of extensive radiofrequency energy applications in the pulmonary veins in dogs</title><author>TAYLOR, G. W ; KAY, G. N ; XIANGSHENG ZHENG ; BISHOP, S ; IDEKER, R. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-cc347da7ee6d9c8e26f8c89fe4f4fb91a03e3c13ba2366c64ee9d28c6ead30963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Catheter Ablation - adverse effects</topic><topic>Constriction, Pathologic</topic><topic>Diseases of the cardiovascular system</topic><topic>Dogs</topic><topic>Female</topic><topic>Hemodynamics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pulmonary Veins - pathology</topic><topic>Pulmonary Veins - physiopathology</topic><topic>Pulmonary Veins - radiation effects</topic><topic>Pulmonary Veins - surgery</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Tunica Intima - pathology</topic><topic>Tunica Intima - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TAYLOR, G. W</creatorcontrib><creatorcontrib>KAY, G. N</creatorcontrib><creatorcontrib>XIANGSHENG ZHENG</creatorcontrib><creatorcontrib>BISHOP, S</creatorcontrib><creatorcontrib>IDEKER, R. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TAYLOR, G. W</au><au>KAY, G. N</au><au>XIANGSHENG ZHENG</au><au>BISHOP, S</au><au>IDEKER, R. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathological effects of extensive radiofrequency energy applications in the pulmonary veins in dogs</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2000-04-11</date><risdate>2000</risdate><volume>101</volume><issue>14</issue><spage>1736</spage><epage>1742</epage><pages>1736-1742</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>The long-term complications of catheter ablation within the pulmonary veins are unknown. The development of pulmonary vein stenosis has recently been described after catheter ablation to treat either chronic or paroxysmal atrial fibrillation. The purpose of this study was to examine the pathological and hemodynamic effects of radiofrequency (RF) energy application within the pulmonary veins.
Right heart and transseptal catheterization were performed in 9 anesthetized mongrel dogs. The pulmonary vein ostia were cannulated and pulmonary venous pressure was measured before RF energy application in up to 4 separate pulmonary veins. Animals were euthanized at intervals of 2 to 4 weeks (n=3), 6 to 8 weeks (n=3), or 10 to 14 weeks (n=3) after ablation. Repeat catheterization before euthanasia demonstrated statistically significant differences in pulmonary capillary wedge pressure, cardiac output, pulmonary vascular resistance, and systemic vascular resistance (P<0.05) compared with the baseline. Luminal narrowing was observed in 22 of 33 pulmonary veins to which RF energy was applied. Of these, 7 were totally occluded, 7 had severe stenosis, and 8 were only minimally narrowed. Histological examination revealed intimal proliferation with organizing thrombus, necrotic myocardium in various stages of collagen replacement, endovascular contraction, and a proliferation of elastic lamina.
Applications of RF current within the pulmonary veins may result in pulmonary vein narrowing or complete occlusion. These observations should be considered in treatment of arrhythmias originating within the pulmonary veins.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10758058</pmid><doi>10.1161/01.cir.101.14.1736</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 2000-04, Vol.101 (14), p.1736-1742 |
| issn | 0009-7322 1524-4539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71034232 |
| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Catheter Ablation - adverse effects Constriction, Pathologic Diseases of the cardiovascular system Dogs Female Hemodynamics Male Medical sciences Pulmonary Veins - pathology Pulmonary Veins - physiopathology Pulmonary Veins - radiation effects Pulmonary Veins - surgery Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Tunica Intima - pathology Tunica Intima - radiation effects |
| title | Pathological effects of extensive radiofrequency energy applications in the pulmonary veins in dogs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T21%3A04%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pathological%20effects%20of%20extensive%20radiofrequency%20energy%20applications%20in%20the%20pulmonary%20veins%20in%20dogs&rft.jtitle=Circulation%20(New%20York,%20N.Y.)&rft.au=TAYLOR,%20G.%20W&rft.date=2000-04-11&rft.volume=101&rft.issue=14&rft.spage=1736&rft.epage=1742&rft.pages=1736-1742&rft.issn=0009-7322&rft.eissn=1524-4539&rft.coden=CIRCAZ&rft_id=info:doi/10.1161/01.cir.101.14.1736&rft_dat=%3Cproquest_cross%3E71034232%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=212675077&rft_id=info:pmid/10758058&rfr_iscdi=true |