Gene therapy of experimental brain tumors using neural progenitor cells

Glioblastomas, the most frequent and malignant of primary brain tumors, have a very poor prognosis 1 . Gene therapy of glioblastomas is limited by the short survival of viral vectors and by their difficulty in reaching glioblastoma cells infiltrating the brain parenchyma. Neural stem/progenitor cell...

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Veröffentlicht in:	Nature medicine 2000-04, Vol.6 (4), p.447-450
Hauptverfasser:	Benedetti, Sara, Pirola, Barbara, Pollo, Bianca, Magrassi, Lorenzo, Bruzzone, Maria Grazia, Rigamonti, Dorotea, Galli, Rossella, Selleri, Silvia, Di Meco, Francesco, De Fraja, Claudio, Vescovi, Angelo, Cattaneo, Elena, Finocchiaro, Gaetano
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Brain - pathology Brain cancer Brain Neoplasms - pathology Brain Neoplasms - therapy Brain tumors Cancer Research Cerebral Cortex - cytology Cytokines Enzymes Gene therapy Genetic Therapy Glioblastoma Glioblastoma - pathology Glioblastoma - therapy Hematopoietic Stem Cell Transplantation Humans Infectious Diseases Injection Interleukin-4 - genetics Interleukin-4 - immunology Magnetic Resonance Imaging Metabolic Diseases Mice Mice, Inbred C57BL Molecular Medicine Neurons - cytology Neurons - metabolism Neurons - transplantation Neurosciences Rats Rats, Sprague-Dawley Stem cells Survival Tumors
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