Elevated Levels of Cyclooxygenase-2 in Antigen-Stimulated Mast Cells Is Associated with Minimal Activation of p38 Mitogen-Activated Protein Kinase

We have investigated possible factors that underlie changes in the production of eicosanoids after prolonged exposure of mast cells to Ag. Ag stimulation of cultured RBL-2H3 mast cells resulted in increased expression of cyclooxygenase (COX-2) protein and message. Other eicosanoid-related enzymes, n...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2001-08, Vol.167 (3), p.1629-1636
Hauptverfasser:	Hundley, Thomas R, Prasad, Anjana R, Beaven, Michael A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens - immunology Arachidonate 5-Lipoxygenase - biosynthesis Cyclooxygenase 1 Cyclooxygenase 2 Dexamethasone - pharmacology Dinitrophenols - immunology Dose-Response Relationship, Immunologic eicosanoids Enzyme Activation - immunology Enzyme Induction - immunology Enzyme Inhibitors - pharmacology Imidazoles - pharmacology Isoenzymes - antagonists & inhibitors Isoenzymes - biosynthesis JNK Mitogen-Activated Protein Kinases Lipoxygenase Inhibitors MAP Kinase Signaling System - immunology Mast Cells - drug effects Mast Cells - enzymology Mast Cells - immunology Membrane Proteins Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinases - physiology p38 Mitogen-Activated Protein Kinases p38 protein Phospholipases A - antagonists & inhibitors Phospholipases A - biosynthesis Phosphorylation Prostaglandin-Endoperoxide Synthases - biosynthesis Pyridines - pharmacology Rats Serum Albumin, Bovine - immunology Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!