Laryngeal Blastomycosis: A Commonly Missed Diagnosis Report of Two Cases and Review of the Literature
Blastomycosis is a relatively uncommon fungal disease that most commonly affects the lungs. Other organs may be involved, usually secondary to dissemination of the organism. Laryngeal blastomycosis may occur in isolation from active pulmonary disease. The signs, symptoms, clinical features, and path...
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| Veröffentlicht in: | Annals of otology, rhinology & laryngology rhinology & laryngology, 2000-03, Vol.109 (3), p.281-286 |
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| creator | Hanson, Jason M. Spector, Gershon El-Mofty, Samir K. |
| description | Blastomycosis is a relatively uncommon fungal disease that most commonly affects the lungs. Other organs may be involved, usually secondary to dissemination of the organism. Laryngeal blastomycosis may occur in isolation from active pulmonary disease. The signs, symptoms, clinical features, and pathological findings of laryngeal blastomycosis mimic those of squamous cell carcinoma. Misdiagnosis may result in inappropriate treatment with potential morbidity. Proper understanding of the clinical presentation and familiarity with the histopathologic features of this disease are therefore imperative. In this paper, we report 2 cases of laryngeal blastomycosis, 1 of which was misdiagnosed as squamous cell carcinoma, clinically and microscopically, with consequent radiotherapy and laryngectomy. In the other case, a clinical diagnosis of glottic squamous cell carcinoma was rendered. However, blastomycosis was identified in a biopsy specimen. We also review cases of isolated laryngeal blastomycosis that have been reported in the English-language literature during the last 80 years. a number of those cases were misdiagnosed clinically and microscopically as squamous cell carcinoma. |
| doi_str_mv | 10.1177/000348940010900309 |
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Other organs may be involved, usually secondary to dissemination of the organism. Laryngeal blastomycosis may occur in isolation from active pulmonary disease. The signs, symptoms, clinical features, and pathological findings of laryngeal blastomycosis mimic those of squamous cell carcinoma. Misdiagnosis may result in inappropriate treatment with potential morbidity. Proper understanding of the clinical presentation and familiarity with the histopathologic features of this disease are therefore imperative. In this paper, we report 2 cases of laryngeal blastomycosis, 1 of which was misdiagnosed as squamous cell carcinoma, clinically and microscopically, with consequent radiotherapy and laryngectomy. In the other case, a clinical diagnosis of glottic squamous cell carcinoma was rendered. However, blastomycosis was identified in a biopsy specimen. We also review cases of isolated laryngeal blastomycosis that have been reported in the English-language literature during the last 80 years. a number of those cases were misdiagnosed clinically and microscopically as squamous cell carcinoma.</description><identifier>ISSN: 0003-4894</identifier><identifier>EISSN: 1943-572X</identifier><identifier>DOI: 10.1177/000348940010900309</identifier><identifier>PMID: 10737312</identifier><identifier>CODEN: AORHA2</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Amphotericin B - therapeutic use ; Antifungal Agents - therapeutic use ; Biological and medical sciences ; Blastomyces - cytology ; Blastomycosis - complications ; Blastomycosis - diagnosis ; Blastomycosis - drug therapy ; Carcinoma, Squamous Cell - diagnosis ; Diagnosis, Differential ; Diagnostic Errors ; Ent and stomatologic mycoses ; Ent. Stomatology ; Female ; Human mycoses ; Humans ; Infectious diseases ; Laryngeal Neoplasms - diagnosis ; Laryngitis - diagnosis ; Laryngitis - drug therapy ; Laryngitis - microbiology ; Male ; Medical sciences ; Middle Aged ; Mycoses ; Pharmacology. 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Other organs may be involved, usually secondary to dissemination of the organism. Laryngeal blastomycosis may occur in isolation from active pulmonary disease. The signs, symptoms, clinical features, and pathological findings of laryngeal blastomycosis mimic those of squamous cell carcinoma. Misdiagnosis may result in inappropriate treatment with potential morbidity. Proper understanding of the clinical presentation and familiarity with the histopathologic features of this disease are therefore imperative. In this paper, we report 2 cases of laryngeal blastomycosis, 1 of which was misdiagnosed as squamous cell carcinoma, clinically and microscopically, with consequent radiotherapy and laryngectomy. In the other case, a clinical diagnosis of glottic squamous cell carcinoma was rendered. However, blastomycosis was identified in a biopsy specimen. We also review cases of isolated laryngeal blastomycosis that have been reported in the English-language literature during the last 80 years. a number of those cases were misdiagnosed clinically and microscopically as squamous cell carcinoma.</description><subject>Amphotericin B - therapeutic use</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blastomyces - cytology</subject><subject>Blastomycosis - complications</subject><subject>Blastomycosis - diagnosis</subject><subject>Blastomycosis - drug therapy</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Diagnostic Errors</subject><subject>Ent and stomatologic mycoses</subject><subject>Ent. Stomatology</subject><subject>Female</subject><subject>Human mycoses</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Laryngeal Neoplasms - diagnosis</subject><subject>Laryngitis - diagnosis</subject><subject>Laryngitis - drug therapy</subject><subject>Laryngitis - microbiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mycoses</subject><subject>Pharmacology. 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Other organs may be involved, usually secondary to dissemination of the organism. Laryngeal blastomycosis may occur in isolation from active pulmonary disease. The signs, symptoms, clinical features, and pathological findings of laryngeal blastomycosis mimic those of squamous cell carcinoma. Misdiagnosis may result in inappropriate treatment with potential morbidity. Proper understanding of the clinical presentation and familiarity with the histopathologic features of this disease are therefore imperative. In this paper, we report 2 cases of laryngeal blastomycosis, 1 of which was misdiagnosed as squamous cell carcinoma, clinically and microscopically, with consequent radiotherapy and laryngectomy. In the other case, a clinical diagnosis of glottic squamous cell carcinoma was rendered. However, blastomycosis was identified in a biopsy specimen. 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| ispartof | Annals of otology, rhinology & laryngology, 2000-03, Vol.109 (3), p.281-286 |
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| subjects | Amphotericin B - therapeutic use Antifungal Agents - therapeutic use Biological and medical sciences Blastomyces - cytology Blastomycosis - complications Blastomycosis - diagnosis Blastomycosis - drug therapy Carcinoma, Squamous Cell - diagnosis Diagnosis, Differential Diagnostic Errors Ent and stomatologic mycoses Ent. Stomatology Female Human mycoses Humans Infectious diseases Laryngeal Neoplasms - diagnosis Laryngitis - diagnosis Laryngitis - drug therapy Laryngitis - microbiology Male Medical sciences Middle Aged Mycoses Pharmacology. Drug treatments |
| title | Laryngeal Blastomycosis: A Commonly Missed Diagnosis Report of Two Cases and Review of the Literature |
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