Structural biology and its applications to the health sciences
Part of the decipherment of genomic information lies in understanding the structure and function of the protein products of these genes. Protein structure is of further importance because of the molecular basis of many diseases. Structural biology is the field of research focusing on the experimenta...
Gespeichert in:
| Veröffentlicht in: | Croatian medical journal 2001-08, Vol.42 (4), p.375-378 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 378 |
|---|---|
| container_issue | 4 |
| container_start_page | 375 |
| container_title | Croatian medical journal |
| container_volume | 42 |
| creator | Oakley, A J Ketterman, A Wilce, M C |
| description | Part of the decipherment of genomic information lies in understanding the structure and function of the protein products of these genes. Protein structure is of further importance because of the molecular basis of many diseases. Structural biology is the field of research focusing on the experimental determination of the structure of biological molecules. We review the field of structural biology and its application to medical research and drug discovery, and describe the structural results recently obtained in our laboratory for the detoxifying enzyme glutathione S-transferase from the Asian mosquito Anopheles dirus species B, an important malaria vector. These enzymes have detoxifying activity toward pesticides and thus contribute to pesticide resistance in insects. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_71031067</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71031067</sourcerecordid><originalsourceid>FETCH-LOGICAL-p207t-c23304f1d1ccfb651011fe31419a552b40c5d2ea941584cf1ba70d758f9427693</originalsourceid><addsrcrecordid>eNo1j8tKxDAUQLNQnHH0FyQrd4V782jajSCDLxhwoa5LmiY2kjaxSRfz9wqOq7M5HDhnZAtc8qqVIDbkMucvAAZC1BdkgygUYtNsyd1bWVZT1kUH2vsY4ueR6nmgvmSqUwre6OLjnGmJtIyWjlaHMtJsvJ2NzVfk3OmQ7fWJO_Lx-PC-f64Or08v-_tDlRioUhnGOQiHAxrj-loiIDrLUWCrpWS9ACMHZnUrUDbCOOy1gkHJxrWCqbrlO3L7101L_F5tLt3ks7Eh6NnGNXcKgSPU6le8OYlrP9mhS4uf9HLs_o_5D8-AUF4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71031067</pqid></control><display><type>article</type><title>Structural biology and its applications to the health sciences</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Oakley, A J ; Ketterman, A ; Wilce, M C</creator><creatorcontrib>Oakley, A J ; Ketterman, A ; Wilce, M C</creatorcontrib><description>Part of the decipherment of genomic information lies in understanding the structure and function of the protein products of these genes. Protein structure is of further importance because of the molecular basis of many diseases. Structural biology is the field of research focusing on the experimental determination of the structure of biological molecules. We review the field of structural biology and its application to medical research and drug discovery, and describe the structural results recently obtained in our laboratory for the detoxifying enzyme glutathione S-transferase from the Asian mosquito Anopheles dirus species B, an important malaria vector. These enzymes have detoxifying activity toward pesticides and thus contribute to pesticide resistance in insects.</description><identifier>ISSN: 0353-9504</identifier><identifier>PMID: 11471188</identifier><language>eng</language><publisher>Croatia</publisher><subject>Amino Acid Sequence ; Animals ; Anopheles - genetics ; Crystallography, X-Ray ; Drug Design ; Genes ; Glutathione Transferase - genetics ; Humans ; Insect Vectors ; Magnetic Resonance Spectroscopy ; Protein Conformation</subject><ispartof>Croatian medical journal, 2001-08, Vol.42 (4), p.375-378</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11471188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oakley, A J</creatorcontrib><creatorcontrib>Ketterman, A</creatorcontrib><creatorcontrib>Wilce, M C</creatorcontrib><title>Structural biology and its applications to the health sciences</title><title>Croatian medical journal</title><addtitle>Croat Med J</addtitle><description>Part of the decipherment of genomic information lies in understanding the structure and function of the protein products of these genes. Protein structure is of further importance because of the molecular basis of many diseases. Structural biology is the field of research focusing on the experimental determination of the structure of biological molecules. We review the field of structural biology and its application to medical research and drug discovery, and describe the structural results recently obtained in our laboratory for the detoxifying enzyme glutathione S-transferase from the Asian mosquito Anopheles dirus species B, an important malaria vector. These enzymes have detoxifying activity toward pesticides and thus contribute to pesticide resistance in insects.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Anopheles - genetics</subject><subject>Crystallography, X-Ray</subject><subject>Drug Design</subject><subject>Genes</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>Insect Vectors</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Protein Conformation</subject><issn>0353-9504</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j8tKxDAUQLNQnHH0FyQrd4V782jajSCDLxhwoa5LmiY2kjaxSRfz9wqOq7M5HDhnZAtc8qqVIDbkMucvAAZC1BdkgygUYtNsyd1bWVZT1kUH2vsY4ueR6nmgvmSqUwre6OLjnGmJtIyWjlaHMtJsvJ2NzVfk3OmQ7fWJO_Lx-PC-f64Or08v-_tDlRioUhnGOQiHAxrj-loiIDrLUWCrpWS9ACMHZnUrUDbCOOy1gkHJxrWCqbrlO3L7101L_F5tLt3ks7Eh6NnGNXcKgSPU6le8OYlrP9mhS4uf9HLs_o_5D8-AUF4</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>Oakley, A J</creator><creator>Ketterman, A</creator><creator>Wilce, M C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20010801</creationdate><title>Structural biology and its applications to the health sciences</title><author>Oakley, A J ; Ketterman, A ; Wilce, M C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p207t-c23304f1d1ccfb651011fe31419a552b40c5d2ea941584cf1ba70d758f9427693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Anopheles - genetics</topic><topic>Crystallography, X-Ray</topic><topic>Drug Design</topic><topic>Genes</topic><topic>Glutathione Transferase - genetics</topic><topic>Humans</topic><topic>Insect Vectors</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Protein Conformation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oakley, A J</creatorcontrib><creatorcontrib>Ketterman, A</creatorcontrib><creatorcontrib>Wilce, M C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Croatian medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oakley, A J</au><au>Ketterman, A</au><au>Wilce, M C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural biology and its applications to the health sciences</atitle><jtitle>Croatian medical journal</jtitle><addtitle>Croat Med J</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>42</volume><issue>4</issue><spage>375</spage><epage>378</epage><pages>375-378</pages><issn>0353-9504</issn><abstract>Part of the decipherment of genomic information lies in understanding the structure and function of the protein products of these genes. Protein structure is of further importance because of the molecular basis of many diseases. Structural biology is the field of research focusing on the experimental determination of the structure of biological molecules. We review the field of structural biology and its application to medical research and drug discovery, and describe the structural results recently obtained in our laboratory for the detoxifying enzyme glutathione S-transferase from the Asian mosquito Anopheles dirus species B, an important malaria vector. These enzymes have detoxifying activity toward pesticides and thus contribute to pesticide resistance in insects.</abstract><cop>Croatia</cop><pmid>11471188</pmid><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0353-9504 |
| ispartof | Croatian medical journal, 2001-08, Vol.42 (4), p.375-378 |
| issn | 0353-9504 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71031067 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Amino Acid Sequence Animals Anopheles - genetics Crystallography, X-Ray Drug Design Genes Glutathione Transferase - genetics Humans Insect Vectors Magnetic Resonance Spectroscopy Protein Conformation |
| title | Structural biology and its applications to the health sciences |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T11%3A41%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Structural%20biology%20and%20its%20applications%20to%20the%20health%20sciences&rft.jtitle=Croatian%20medical%20journal&rft.au=Oakley,%20A%20J&rft.date=2001-08-01&rft.volume=42&rft.issue=4&rft.spage=375&rft.epage=378&rft.pages=375-378&rft.issn=0353-9504&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E71031067%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71031067&rft_id=info:pmid/11471188&rfr_iscdi=true |