Characteristics of immunoglobulin gene usage of the xenoantibody binding to gal-alpha(1,3)gal target antigens in the gal knockout mouse

Natural antibodies that react with galactose-alpha(1,3)galactose [galalpha(1,3)gal] carbohydrate epitopes exist in humans and Old World primates because of the inactivation of the alpha1,3-galactosyltransferase (alpha1,3GT) gene in these species and the subsequent production of antibodies to environ...

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Veröffentlicht in:	Transplantation 2001-07, Vol.72 (1), p.147-155
Hauptverfasser:	Nozawa, S, Xing, P X, Wu, G D, Gochi, E, Kearns-Jonker, M, Swensson, J, Starnes, V A, Sandrin, M S, McKenzie, I F, Cramer, D V
Format:	Artikel
Sprache:	eng
Schlagworte:	a-1,3-Galactosyltransferase Amino Acid Sequence - genetics Animals Antibodies, Heterophile - genetics Antibodies, Heterophile - immunology Antigens, Heterophile - immunology Base Sequence - genetics carbohydrates Disaccharides - immunology Epitopes - genetics Galactosyltransferases - deficiency Galactosyltransferases - genetics Genes, Immunoglobulin - physiology Immunoglobulin Heavy Chains - genetics Immunoglobulin Light Chains - genetics Immunoglobulin Variable Region - genetics Mice Mice, Knockout - genetics Molecular Sequence Data Swine
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