Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures

The midbrain-hindbrain (MHB) junction has the properties of an organizer that patterns the MHB region early in vertebrate development. Fgf8 is thought to mediate this organizer function. In addition to Fgf8, Fgf17 and Fgf18 are also expressed in the MHB junction. Fgf17 is expressed later and broader...

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Veröffentlicht in:	Development (Cambridge) 2000-05, Vol.127 (9), p.1833-1843
Hauptverfasser:	Xu, J, Liu, Z, Ornitz, D M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calbindins Cell Differentiation Cell Division Cell Movement Cerebellum - embryology Cerebellum - metabolism Fgf17 gene Fgf8 gene Fibroblast Growth Factor 8 Fibroblast Growth Factors - genetics Fibroblast Growth Factors - metabolism Fluorescent Antibody Technique Gene Expression Regulation, Developmental Gene Targeting Histocytochemistry In Situ Hybridization Mice Mice, Knockout Phenotype S100 Calcium Binding Protein G - metabolism Signal Transduction - genetics
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