A purified GM3 ganglioside conjugated vaccine induces specific, adjuvant-dependent and non-transient antitumour activity against B16 mouse melanoma in vitro and in vivo

The presence of substantial amounts of GM3 ganglioside on human melanomas and other tumours, together with its peculiar biological properties, makes this glycolipid a unique target for cancer immunotherapy. B16 mouse melanoma expresses GM3 and constitutes an appropriate model for the development of...

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Veröffentlicht in:	Melanoma research 2001-06, Vol.11 (3), p.219-227
Hauptverfasser:	Carr, A, Mazorra, Z, Alonso, D F, Mesa, C, Valiente, O, Gomez, D E, Perez, R, Fernandez, L E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatography, Thin Layer Dogs Enzyme-Linked Immunosorbent Assay Female G(M3) Ganglioside - metabolism Horses Immunoglobulin G - metabolism Immunoglobulin M - metabolism Immunophenotyping Melanoma, Experimental - therapy Mice Mice, Inbred BALB C Mice, Inbred C57BL Neuraminic Acids - metabolism Time Factors Vaccines, DNA
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