NF-kappa B activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-kappa B

We recently reported that inhibition of NF-kappa B activation as a consequence of the overexpression of a degradation-resistant form of I kappa B alpha [I kappa B alpha(A32/36)] sensitized Ewing sarcoma cells to TNF alpha-induced killing. The c-Jun N-terminal kinases (JNK) have been shown to partici...

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Veröffentlicht in:	Oncogene 2001-07, Vol.20 (32), p.4365-4372
Hauptverfasser:	Javelaud, D, Besançon, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bone Neoplasms - enzymology Bone Neoplasms - metabolism c-Jun protein Care and treatment Caspase Caspase inhibitors Caspases - physiology Cell activation Cyclin-Dependent Kinase Inhibitor p21 Cyclins - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Ewing's sarcoma Ewings sarcoma Ewings's sarcoma Fungal Proteins Genetic aspects Health aspects Humans I-kappa B Proteins JNK protein Kinases Kinetics MAP kinase Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism Models, Biological Mutation NF-kappa B - metabolism NF-KappaB Inhibitor alpha NF-κB protein p38 Mitogen-Activated Protein Kinases Phosphorylation Risk factors Sarcoma, Ewing - enzymology Sarcoma, Ewing - metabolism Transcription factors Transfection Tumor Cells, Cultured Tumor necrosis factor Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-α Vanadate
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