Pharmacodynamics and pharmacokinetics of higher-dose, double-bolus eptifibatide in percutaneous coronary intervention

Pharmacodynamics of eptifibatide, a cyclic heptapeptide antagonist of platelet glycoprotein IIb/IIIa, are substantially altered by anticoagulants that chelate calcium, resulting in overestimation ex vivo of the in vivo effects of this agent. We conducted a dose-ranging study to characterize the phar...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2001-07, Vol.104 (4), p.406-411
Hauptverfasser:	GILCHRIST, Ian C, O'SHEA, J. Conor, RUNYON, John, TCHENG, James E, KOSOGLOU, Teddy, JENNINGS, Lisa K, LORENZ, Todd J, KITT, Michael M, KLEIMAN, Neal S, TALLEY, David, AGUIRRE, Frank, DAVIDSON, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Angioplasty, Balloon, Coronary Area Under Curve Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Dose-Response Relationship, Drug Eptifibatide Female Humans Male Medical sciences Metabolic Clearance Rate Middle Aged Peptides - pharmacokinetics Pharmacology. Drug treatments Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacokinetics Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors Time Factors
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