Tuning Lipase Enantioselectivity in Organic Media Using Solid-State Buffers

The enantioselectivity exhibited by Candida antarctica lipase B (CALB) in predominantly organic media has been studied for different enzyme protonation states. Alcoholysis of (±)-2-phenyl-4-benzyloxazol-5(4H)-one (1) using butan-1-ol as the nucleophile in low-water organic solvents was used as a mod...

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Veröffentlicht in:	Journal of organic chemistry 2001-07, Vol.66 (15), p.5074-5079
Hauptverfasser:	Quirós, Margarita, Parker, Marie-Claire, Turner, Nicholas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Buffers Candida - enzymology Catalysis Lipase - chemistry Mucor - enzymology Solvents Stereoisomerism Thermodynamics
Online-Zugang:	Volltext
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