A Hospital-Based Prevalence Survey of Bloodstream Infections in Febrile Patients in Malawi: Implications for Diagnosis and Therapy

A Hospital-Based Prevalence Survey of Bloodstream Infections in Febrile Patients in Malawi: Implications for Diagnosis and Therapy

The etiology of bloodstream infections (BSIs) in febrile (⩾37.5°C) adults (⩾18 years old) in one Malawi hospital were determined during August and September 1997. After clinical evaluation, blood was drawn for comprehensive culture, human immunodeficiency virus (HIV) type 1 testing, and malaria smea...

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Veröffentlicht in:The Journal of infectious diseases 2000-04, Vol.181 (4), p.1414-1420
Hauptverfasser: Archibald, Lennox K., McDonald, L. Clifford, Nwanyanwu, Okey, Kazembe, Peter, Dobbie, Hamish, Tokars, Jerome, Reller, L. Barth, Jarvis, William R.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
AIDS/HIV
Antimicrobials
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
Blood
Cohort Studies
Female
Fever
Fever - epidemiology
Fever - etiology
HIV
HIV 1
HIV Infections - complications
HIV Infections - diagnosis
Hospitalization
Human bacterial diseases
Humans
Infections
Infectious diseases
Major Article
Malaria
Malaria - complications
Malaria - diagnosis
Malaria - epidemiology
Malawi - epidemiology
Male
Medical sciences
Middle Aged
Mycobacterium tuberculosis
Pathogens
Predisposing factors
Prevalence
Prospective Studies
Sepsis - complications
Sepsis - diagnosis
Sepsis - therapy
Streptococcal Infections - complications
Streptococcal Infections - diagnosis
Streptococcus pneumoniae
Tuberculosis - complications
Tuberculosis - diagnosis
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Zusammenfassung:The etiology of bloodstream infections (BSIs) in febrile (⩾37.5°C) adults (⩾18 years old) in one Malawi hospital were determined during August and September 1997. After clinical evaluation, blood was drawn for comprehensive culture, human immunodeficiency virus (HIV) type 1 testing, and malaria smear. Of 233 patients, 173 (74%) were HIV-1 infected, and 70 (30%) had BSI. BSI pathogens included 25 (33%) Streptococcus pneumoniae and 21 (28%) Mycobacterium tuberculosis. Nine patients (4%) had malaria parasitemia. BSIs were more likely in HIV-1—positive than in —negative patients (62/173 vs. 8/60, P
ISSN:0022-1899
1537-6613
DOI:10.1086/315367