In vitro and in vivo inhibition of LPS-stimulated tumor necrosis factor-α secretion by the gallotannin β-D-pentagalloylglucose

The naturally occurring gallotannin beta-D-pentagalloylglucose (beta-PGG) decreases tumor necrosis factor-alpha (TNF-alpha) output from human peripheral blood mononucleocytes exposed to lipopolysaccharide (LPS) by as much as 90% (vs control) at approximately 5 microM concentration. A qualitatively s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2001-07, Vol.11 (14), p.1813-1815
Hauptverfasser:	FELDMAN, Ken S, SAHASRABUDHE, Kiran, LAWLOR, Michael D, WILSON, Sarah L, LANG, Charles H, SCHEUCHENZUBER, William J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Factors - pharmacology Dose-Response Relationship, Drug Female General pharmacology Hydrolyzable Tannins - analogs & derivatives Hydrolyzable Tannins - pharmacology Immunomodulators Interleukin-1 - agonists Interleukin-1 - blood Leukocytes, Mononuclear - metabolism Lipopolysaccharides - pharmacology Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Rats Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!