In vitro and in vivo inhibition of LPS-stimulated tumor necrosis factor-α secretion by the gallotannin β-D-pentagalloylglucose
The naturally occurring gallotannin beta-D-pentagalloylglucose (beta-PGG) decreases tumor necrosis factor-alpha (TNF-alpha) output from human peripheral blood mononucleocytes exposed to lipopolysaccharide (LPS) by as much as 90% (vs control) at approximately 5 microM concentration. A qualitatively s...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2001-07, Vol.11 (14), p.1813-1815 |
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| container_issue | 14 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | FELDMAN, Ken S SAHASRABUDHE, Kiran LAWLOR, Michael D WILSON, Sarah L LANG, Charles H SCHEUCHENZUBER, William J |
| description | The naturally occurring gallotannin beta-D-pentagalloylglucose (beta-PGG) decreases tumor necrosis factor-alpha (TNF-alpha) output from human peripheral blood mononucleocytes exposed to lipopolysaccharide (LPS) by as much as 90% (vs control) at approximately 5 microM concentration. A qualitatively similar but less pronounced effect ( approximately 50% decrease) was observed in the serum of rats dosed with both LPS and beta-PGG. These results may have relevance to therapies that target disease states characterized by an overproduction of TNF-alpha. |
| doi_str_mv | 10.1016/S0960-894X(01)00332-8 |
| format | Article |
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A qualitatively similar but less pronounced effect ( approximately 50% decrease) was observed in the serum of rats dosed with both LPS and beta-PGG. These results may have relevance to therapies that target disease states characterized by an overproduction of TNF-alpha.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological Factors - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Hydrolyzable Tannins - analogs & derivatives</subject><subject>Hydrolyzable Tannins - pharmacology</subject><subject>Immunomodulators</subject><subject>Interleukin-1 - agonists</subject><subject>Interleukin-1 - blood</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkN9qFDEUxkNR2rX6CC25kKIX0ZPJn525LK1_CgsWquBdyGQybSSTrEmmsHe-kj5In6nZ7aJeHc7H932H80PohMI7ClS-v4FOAmk7_v0N0LcAjDWkPUALyiUnjIN4hhZ_LUfoRc4_ACgHzg_REaVcdJK1C_TrKuB7V1LEOgzYbZf7WOed611xMeA44tX1DcnFTbPXxQ64zFNMOFiTYnYZj9qUmMjDb5yrZHehfoPLncW32vtYdAi19-EPuSRrG4reqRt_62cTs32Jno_aZ_tqP4_Rt48fvl58Jqsvn64uzlfEsFYWInTXSTPwQVoQPXRaCsEE1VbyvpG0vi-qXBcq6TCwXkDTDFRDv-RtA4azY3T21LtO8edsc1GTy8Z6r4ONc1ZLCs2ya5pqFE_G7X852VGtk5t02igKaote7dCrLVcFVO3Qq7bmTvcH5n6yw7_UnnU1vN4bdDbaj0kH4_J_7UIAE-wRtkuOqg</recordid><startdate>20010723</startdate><enddate>20010723</enddate><creator>FELDMAN, Ken S</creator><creator>SAHASRABUDHE, Kiran</creator><creator>LAWLOR, Michael D</creator><creator>WILSON, Sarah L</creator><creator>LANG, Charles H</creator><creator>SCHEUCHENZUBER, William J</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010723</creationdate><title>In vitro and in vivo inhibition of LPS-stimulated tumor necrosis factor-α secretion by the gallotannin β-D-pentagalloylglucose</title><author>FELDMAN, Ken S ; SAHASRABUDHE, Kiran ; LAWLOR, Michael D ; WILSON, Sarah L ; LANG, Charles H ; SCHEUCHENZUBER, William J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-5a996cd4d6e05b09a655351ae64b26103355b064b161dd3b5022d1a0b74820c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological Factors - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>General pharmacology</topic><topic>Hydrolyzable Tannins - analogs & derivatives</topic><topic>Hydrolyzable Tannins - pharmacology</topic><topic>Immunomodulators</topic><topic>Interleukin-1 - agonists</topic><topic>Interleukin-1 - blood</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Medical sciences</topic><topic>Pharmacognosy. 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Drug treatments</topic><topic>Rats</topic><topic>Tumor Necrosis Factor-alpha - antagonists & inhibitors</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FELDMAN, Ken S</creatorcontrib><creatorcontrib>SAHASRABUDHE, Kiran</creatorcontrib><creatorcontrib>LAWLOR, Michael D</creatorcontrib><creatorcontrib>WILSON, Sarah L</creatorcontrib><creatorcontrib>LANG, Charles H</creatorcontrib><creatorcontrib>SCHEUCHENZUBER, William J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FELDMAN, Ken S</au><au>SAHASRABUDHE, Kiran</au><au>LAWLOR, Michael D</au><au>WILSON, Sarah L</au><au>LANG, Charles H</au><au>SCHEUCHENZUBER, William J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro and in vivo inhibition of LPS-stimulated tumor necrosis factor-α secretion by the gallotannin β-D-pentagalloylglucose</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2001-07-23</date><risdate>2001</risdate><volume>11</volume><issue>14</issue><spage>1813</spage><epage>1815</epage><pages>1813-1815</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>The naturally occurring gallotannin beta-D-pentagalloylglucose (beta-PGG) decreases tumor necrosis factor-alpha (TNF-alpha) output from human peripheral blood mononucleocytes exposed to lipopolysaccharide (LPS) by as much as 90% (vs control) at approximately 5 microM concentration. 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| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (14), p.1813-1815 |
| issn | 0960-894X 1464-3405 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Biological Factors - pharmacology Dose-Response Relationship, Drug Female General pharmacology Hydrolyzable Tannins - analogs & derivatives Hydrolyzable Tannins - pharmacology Immunomodulators Interleukin-1 - agonists Interleukin-1 - blood Leukocytes, Mononuclear - metabolism Lipopolysaccharides - pharmacology Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Rats Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism |
| title | In vitro and in vivo inhibition of LPS-stimulated tumor necrosis factor-α secretion by the gallotannin β-D-pentagalloylglucose |
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