A clinical and pharmacokinetic trial of six doses of artemether-lumefantrine for multidrug-resistant Plasmodium falciparum malaria in Thailand

The efficacy-safety and pharmacokinetics of the six-dose regimen of artemether-lumefantrine (Coartem/Riamet; Novartis Pharma AG, Basel, Switzerland) were assessed in a randomized trial in 219 patients (> or = 12 years old) with acute, uncomplicated Plasmodium falciparum malaria in Thailand. One h...

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Veröffentlicht in:	The American journal of tropical medicine and hygiene 2001-05, Vol.64 (5), p.247-256
Hauptverfasser:	Lefevre, G, Looareesuwan, S, Treeprasertsuk, S, Krudsood, S, Silachamroon, U, Gathmann, I, Mull, R, Bakshi, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials - administration & dosage Antimalarials - pharmacokinetics Antimalarials - pharmacology Antimalarials - therapeutic use Antiparasitic agents Artemether Artemisinins artesunate Biological and medical sciences Child Drug Resistance Drug Therapy, Combination Ethanolamines - administration & dosage Ethanolamines - pharmacokinetics Ethanolamines - pharmacology Ethanolamines - therapeutic use Female Fluorenes - administration & dosage Fluorenes - pharmacokinetics Fluorenes - pharmacology Fluorenes - therapeutic use Humans Lumefantrine Malaria, Falciparum - drug therapy Male Medical sciences mefloquine Middle Aged Pharmacology. Drug treatments Plasmodium falciparum Plasmodium falciparum - drug effects Polymerase Chain Reaction Sesquiterpenes - administration & dosage Sesquiterpenes - pharmacokinetics Sesquiterpenes - pharmacology Sesquiterpenes - therapeutic use Thailand Tropical medicine
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