Complexation of Ginkgo biloba Extract with Phosphatidylcholine Improves Cardioprotective Activity and Increases the Plasma Antioxidant Capacity in the Rat
Abstract The aim of this work was to compare in the rat the cardioprotective efficacy and the total plasma antioxidant activity of a standardised GINKGO BILOBA L. extract (GB) as such (300 mg/kg/day) or complexed with phosphatidylcholine (GB-PC; 1 : 2 w/w), after a 5 days oral administration. At the...
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| Veröffentlicht in: | Planta medica 2001-06, Vol.67 (4), p.326-330 |
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| creator | Carini, Marina Aldini, Giancarlo Rossoni, Giuseppe Morazzoni, Paolo Facino, Roberto Maffei |
| description | Abstract
The aim of this work was to compare in the rat the cardioprotective efficacy and the total plasma antioxidant activity of a standardised GINKGO BILOBA L. extract (GB) as such (300 mg/kg/day) or complexed with phosphatidylcholine (GB-PC; 1 : 2 w/w), after a 5 days oral administration. At the end of the treatment, the total plasma antioxidant defence was determined by the TRAP and FRAP assays, and the hearts from all groups of animals subjected to moderate ischemia (flow reduction to 1 ml/min for 20 min) and reperfusion (15 ml/min for 30 min). The recovery of left ventricular developed pressure (LVDP) at the end of reperfusion was 35 - 40 % of the preischemic values in both control and vehicle rats, 50.2 % in the GB group and 72.5 % in the GB-PC pre-treated animals. Creatine kinase (CK) outflow in the perfusate from the hearts of GB and GB-PC treated animals were restrained to a different extent vs. controls (by 71 % GB-PC; by 22 % GB); the rate of prostacyclin (6-keto-PGF
1α
) release was far greater in GB-PC than in GB hearts. In parallel, the GB extract significantly increased the total antioxidant plasma capacity (by 24.5 % TRAP; 27.9 % FRAP) only when complexed with phospholipids. This indicates an increased bioavailability of phenolic antioxidants when suitably embedded within a lipophilic carrier. The results of this study demonstrate that complexation of GINKGO BILOBA with phospholipids induces in the rat, even after a short treatment a greater resistance of the heart to ischemia/reperfusion damage in respect to the native extract, due to an increased plasma antioxidant activity. |
| doi_str_mv | 10.1055/s-2001-14313 |
| format | Article |
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The aim of this work was to compare in the rat the cardioprotective efficacy and the total plasma antioxidant activity of a standardised GINKGO BILOBA L. extract (GB) as such (300 mg/kg/day) or complexed with phosphatidylcholine (GB-PC; 1 : 2 w/w), after a 5 days oral administration. At the end of the treatment, the total plasma antioxidant defence was determined by the TRAP and FRAP assays, and the hearts from all groups of animals subjected to moderate ischemia (flow reduction to 1 ml/min for 20 min) and reperfusion (15 ml/min for 30 min). The recovery of left ventricular developed pressure (LVDP) at the end of reperfusion was 35 - 40 % of the preischemic values in both control and vehicle rats, 50.2 % in the GB group and 72.5 % in the GB-PC pre-treated animals. Creatine kinase (CK) outflow in the perfusate from the hearts of GB and GB-PC treated animals were restrained to a different extent vs. controls (by 71 % GB-PC; by 22 % GB); the rate of prostacyclin (6-keto-PGF
1α
) release was far greater in GB-PC than in GB hearts. In parallel, the GB extract significantly increased the total antioxidant plasma capacity (by 24.5 % TRAP; 27.9 % FRAP) only when complexed with phospholipids. This indicates an increased bioavailability of phenolic antioxidants when suitably embedded within a lipophilic carrier. The results of this study demonstrate that complexation of GINKGO BILOBA with phospholipids induces in the rat, even after a short treatment a greater resistance of the heart to ischemia/reperfusion damage in respect to the native extract, due to an increased plasma antioxidant activity.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2001-14313</identifier><identifier>PMID: 11458448</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Animals ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Biological and medical sciences ; Cardiovascular Agents - pharmacology ; Cardiovascular Agents - therapeutic use ; Drug Combinations ; General pharmacology ; Ginkgo biloba - therapeutic use ; Heart - drug effects ; In Vitro Techniques ; Ischemia - drug therapy ; Male ; Medical sciences ; Medicine, Chinese Traditional ; Myocardial Reperfusion Injury - drug therapy ; Myocardial Reperfusion Injury - prevention & control ; Original Paper ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phosphatidylcholines - blood ; Phosphatidylcholines - pharmacology ; Phosphatidylcholines - therapeutic use ; Phytotherapy ; Plant Extracts - blood ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plants, Medicinal - therapeutic use ; Rats ; Rats, Wistar</subject><ispartof>Planta medica, 2001-06, Vol.67 (4), p.326-330</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-6cb2ec9ceca1ca3f4e6c16d6222023260e5d366263f98e7cc484bda2ace66a123</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2001-14313.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2001-14313$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,777,781,3004,3005,27905,27906,54540,54541</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1044707$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11458448$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carini, Marina</creatorcontrib><creatorcontrib>Aldini, Giancarlo</creatorcontrib><creatorcontrib>Rossoni, Giuseppe</creatorcontrib><creatorcontrib>Morazzoni, Paolo</creatorcontrib><creatorcontrib>Facino, Roberto Maffei</creatorcontrib><title>Complexation of Ginkgo biloba Extract with Phosphatidylcholine Improves Cardioprotective Activity and Increases the Plasma Antioxidant Capacity in the Rat</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>Abstract
The aim of this work was to compare in the rat the cardioprotective efficacy and the total plasma antioxidant activity of a standardised GINKGO BILOBA L. extract (GB) as such (300 mg/kg/day) or complexed with phosphatidylcholine (GB-PC; 1 : 2 w/w), after a 5 days oral administration. At the end of the treatment, the total plasma antioxidant defence was determined by the TRAP and FRAP assays, and the hearts from all groups of animals subjected to moderate ischemia (flow reduction to 1 ml/min for 20 min) and reperfusion (15 ml/min for 30 min). The recovery of left ventricular developed pressure (LVDP) at the end of reperfusion was 35 - 40 % of the preischemic values in both control and vehicle rats, 50.2 % in the GB group and 72.5 % in the GB-PC pre-treated animals. Creatine kinase (CK) outflow in the perfusate from the hearts of GB and GB-PC treated animals were restrained to a different extent vs. controls (by 71 % GB-PC; by 22 % GB); the rate of prostacyclin (6-keto-PGF
1α
) release was far greater in GB-PC than in GB hearts. In parallel, the GB extract significantly increased the total antioxidant plasma capacity (by 24.5 % TRAP; 27.9 % FRAP) only when complexed with phospholipids. This indicates an increased bioavailability of phenolic antioxidants when suitably embedded within a lipophilic carrier. The results of this study demonstrate that complexation of GINKGO BILOBA with phospholipids induces in the rat, even after a short treatment a greater resistance of the heart to ischemia/reperfusion damage in respect to the native extract, due to an increased plasma antioxidant activity.</description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular Agents - pharmacology</subject><subject>Cardiovascular Agents - therapeutic use</subject><subject>Drug Combinations</subject><subject>General pharmacology</subject><subject>Ginkgo biloba - therapeutic use</subject><subject>Heart - drug effects</subject><subject>In Vitro Techniques</subject><subject>Ischemia - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine, Chinese Traditional</subject><subject>Myocardial Reperfusion Injury - drug therapy</subject><subject>Myocardial Reperfusion Injury - prevention & control</subject><subject>Original Paper</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphatidylcholines - blood</subject><subject>Phosphatidylcholines - pharmacology</subject><subject>Phosphatidylcholines - therapeutic use</subject><subject>Phytotherapy</subject><subject>Plant Extracts - blood</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plants, Medicinal - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0U1vEzEQBmALgWgauHFGPiAusMVf62SPUVRKpEqtEJxXs95Z1mXXXmynJH-FX1unidQeOI0sPTNjzUvIO84uOCvLL7EQjPGCK8nlCzLLtSqYEPwlmTEmRcEqJc_IeYx3mamKsdfkjHNVLpVazsi_tR-nAXeQrHfUd_TKut-_PG3s4Bugl7sUwCT616ae3vY-Tn2W7X4wvR-sQ7oZp-DvMdI1hNb6_Ehokr1HujoUm_YUXEs3zgSEmF3qkd4OEEegK5eX7mwLLuX2CcxBW_dIvkN6Q151MER8e6pz8vPr5Y_1t-L65mqzXl0XRpYiFdo0Ak1l0AA3IDuF2nDdaiEEE1JohmUrtRZadtUSF8aopWpaEGBQa-BCzsnH49z8-T9bjKkebTQ4DODQb2O94Ewona84J5-P0AQfY8CunoIdIexrzupDFnWsD1nUj1lk_v40d9uM2D7h0_Ez-HACEA0MXQBnbHw2VKkFW2T26chSb3HE-s5vg8sH-f_WBx3Qogg</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>Carini, Marina</creator><creator>Aldini, Giancarlo</creator><creator>Rossoni, Giuseppe</creator><creator>Morazzoni, Paolo</creator><creator>Facino, Roberto Maffei</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010601</creationdate><title>Complexation of Ginkgo biloba Extract with Phosphatidylcholine Improves Cardioprotective Activity and Increases the Plasma Antioxidant Capacity in the Rat</title><author>Carini, Marina ; Aldini, Giancarlo ; Rossoni, Giuseppe ; Morazzoni, Paolo ; Facino, Roberto Maffei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-6cb2ec9ceca1ca3f4e6c16d6222023260e5d366263f98e7cc484bda2ace66a123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular Agents - pharmacology</topic><topic>Cardiovascular Agents - therapeutic use</topic><topic>Drug Combinations</topic><topic>General pharmacology</topic><topic>Ginkgo biloba - therapeutic use</topic><topic>Heart - drug effects</topic><topic>In Vitro Techniques</topic><topic>Ischemia - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine, Chinese Traditional</topic><topic>Myocardial Reperfusion Injury - drug therapy</topic><topic>Myocardial Reperfusion Injury - prevention & control</topic><topic>Original Paper</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phosphatidylcholines - blood</topic><topic>Phosphatidylcholines - pharmacology</topic><topic>Phosphatidylcholines - therapeutic use</topic><topic>Phytotherapy</topic><topic>Plant Extracts - blood</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plants, Medicinal - therapeutic use</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carini, Marina</creatorcontrib><creatorcontrib>Aldini, Giancarlo</creatorcontrib><creatorcontrib>Rossoni, Giuseppe</creatorcontrib><creatorcontrib>Morazzoni, Paolo</creatorcontrib><creatorcontrib>Facino, Roberto Maffei</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carini, Marina</au><au>Aldini, Giancarlo</au><au>Rossoni, Giuseppe</au><au>Morazzoni, Paolo</au><au>Facino, Roberto Maffei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complexation of Ginkgo biloba Extract with Phosphatidylcholine Improves Cardioprotective Activity and Increases the Plasma Antioxidant Capacity in the Rat</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>67</volume><issue>4</issue><spage>326</spage><epage>330</epage><pages>326-330</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>Abstract
The aim of this work was to compare in the rat the cardioprotective efficacy and the total plasma antioxidant activity of a standardised GINKGO BILOBA L. extract (GB) as such (300 mg/kg/day) or complexed with phosphatidylcholine (GB-PC; 1 : 2 w/w), after a 5 days oral administration. At the end of the treatment, the total plasma antioxidant defence was determined by the TRAP and FRAP assays, and the hearts from all groups of animals subjected to moderate ischemia (flow reduction to 1 ml/min for 20 min) and reperfusion (15 ml/min for 30 min). The recovery of left ventricular developed pressure (LVDP) at the end of reperfusion was 35 - 40 % of the preischemic values in both control and vehicle rats, 50.2 % in the GB group and 72.5 % in the GB-PC pre-treated animals. Creatine kinase (CK) outflow in the perfusate from the hearts of GB and GB-PC treated animals were restrained to a different extent vs. controls (by 71 % GB-PC; by 22 % GB); the rate of prostacyclin (6-keto-PGF
1α
) release was far greater in GB-PC than in GB hearts. In parallel, the GB extract significantly increased the total antioxidant plasma capacity (by 24.5 % TRAP; 27.9 % FRAP) only when complexed with phospholipids. This indicates an increased bioavailability of phenolic antioxidants when suitably embedded within a lipophilic carrier. The results of this study demonstrate that complexation of GINKGO BILOBA with phospholipids induces in the rat, even after a short treatment a greater resistance of the heart to ischemia/reperfusion damage in respect to the native extract, due to an increased plasma antioxidant activity.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>11458448</pmid><doi>10.1055/s-2001-14313</doi><tpages>5</tpages></addata></record> |
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| ispartof | Planta medica, 2001-06, Vol.67 (4), p.326-330 |
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| subjects | Animals Antioxidants - pharmacology Antioxidants - therapeutic use Biological and medical sciences Cardiovascular Agents - pharmacology Cardiovascular Agents - therapeutic use Drug Combinations General pharmacology Ginkgo biloba - therapeutic use Heart - drug effects In Vitro Techniques Ischemia - drug therapy Male Medical sciences Medicine, Chinese Traditional Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - prevention & control Original Paper Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phosphatidylcholines - blood Phosphatidylcholines - pharmacology Phosphatidylcholines - therapeutic use Phytotherapy Plant Extracts - blood Plant Extracts - pharmacology Plant Extracts - therapeutic use Plants, Medicinal - therapeutic use Rats Rats, Wistar |
| title | Complexation of Ginkgo biloba Extract with Phosphatidylcholine Improves Cardioprotective Activity and Increases the Plasma Antioxidant Capacity in the Rat |
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